A Review of Dietary Intake of Acrylamide in Humans
The dietary intake of acrylamide (AA) is a health concern, and food is being monitored worldwide, but the extent of AA exposure from the diet is uncertain. The aim of this review was to provide an overview of estimated dietary intake. We performed a PubMed search identifying studies that used dietar...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Toxics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2305-6304/9/7/155 |
| _version_ | 1797528129298759680 |
|---|---|
| author | Clara Amalie Gade Timmermann Signe Sonne Mølck Manik Kadawathagedara Anne Ahrendt Bjerregaard Margareta Törnqvist Anne Lise Brantsæter Marie Pedersen |
| author_facet | Clara Amalie Gade Timmermann Signe Sonne Mølck Manik Kadawathagedara Anne Ahrendt Bjerregaard Margareta Törnqvist Anne Lise Brantsæter Marie Pedersen |
| author_sort | Clara Amalie Gade Timmermann |
| collection | DOAJ |
| description | The dietary intake of acrylamide (AA) is a health concern, and food is being monitored worldwide, but the extent of AA exposure from the diet is uncertain. The aim of this review was to provide an overview of estimated dietary intake. We performed a PubMed search identifying studies that used dietary questionnaires and recalls to estimate total dietary AA intake. A total of 101 studies were included, corresponding to 68 original study populations from 26 countries. Questionnaires were used in 57 studies, dietary recalls were used in 33 studies, and 11 studies used both methods. The estimated median AA intake ranged from 0.02 to 1.53 μg/kg body weight/day between studies. Children were represented in 25 studies, and the body-weight-adjusted estimated AA intake was up to three times higher for children than adults. The majority of studies were from Europe (<i>n</i> = 65), Asia (<i>n</i> = 17), and the USA (<i>n</i> = 12). Studies from Asia generally estimated lower intakes than studies from Europe and the USA. Differences in methods undermine direct comparison across studies. The assessment of AA intake through dietary questionnaires and recalls has limitations. The integration of these methods with the analysis of validated biomarkers of exposure/internal dose would improve the accuracy of dietary AA intake exposure estimation. This overview shows that AA exposure is widespread and the large variation across and within populations shows a potential for reduced intake among those with the highest exposure. |
| first_indexed | 2024-03-10T09:53:44Z |
| format | Article |
| id | doaj.art-611545c827264f0fa0faaa70d4a63900 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-10T09:53:44Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-611545c827264f0fa0faaa70d4a639002023-11-22T02:31:08ZengMDPI AGToxics2305-63042021-06-019715510.3390/toxics9070155A Review of Dietary Intake of Acrylamide in HumansClara Amalie Gade Timmermann0Signe Sonne Mølck1Manik Kadawathagedara2Anne Ahrendt Bjerregaard3Margareta Törnqvist4Anne Lise Brantsæter5Marie Pedersen6Department of Public Health, University of Copenhagen, 1356 Copenhagen, DenmarkDepartment of Public Health, University of Copenhagen, 1356 Copenhagen, DenmarkInserm, Institut de Recherche en Santé, Environnement et Travail, 35000 Rennes, FranceCenter for Clinical Research and Prevention, Bispebjerg & Frederiksberg Hospital, 2000 Frederiksberg, DenmarkDepartment of Environmental Science, Stockholm University, 10691 Stockholm, SwedenDepartment of Environmental Health, Norwegian Institute of Public Health, 0213 Oslo, NorwayDepartment of Public Health, University of Copenhagen, 1356 Copenhagen, DenmarkThe dietary intake of acrylamide (AA) is a health concern, and food is being monitored worldwide, but the extent of AA exposure from the diet is uncertain. The aim of this review was to provide an overview of estimated dietary intake. We performed a PubMed search identifying studies that used dietary questionnaires and recalls to estimate total dietary AA intake. A total of 101 studies were included, corresponding to 68 original study populations from 26 countries. Questionnaires were used in 57 studies, dietary recalls were used in 33 studies, and 11 studies used both methods. The estimated median AA intake ranged from 0.02 to 1.53 μg/kg body weight/day between studies. Children were represented in 25 studies, and the body-weight-adjusted estimated AA intake was up to three times higher for children than adults. The majority of studies were from Europe (<i>n</i> = 65), Asia (<i>n</i> = 17), and the USA (<i>n</i> = 12). Studies from Asia generally estimated lower intakes than studies from Europe and the USA. Differences in methods undermine direct comparison across studies. The assessment of AA intake through dietary questionnaires and recalls has limitations. The integration of these methods with the analysis of validated biomarkers of exposure/internal dose would improve the accuracy of dietary AA intake exposure estimation. This overview shows that AA exposure is widespread and the large variation across and within populations shows a potential for reduced intake among those with the highest exposure.https://www.mdpi.com/2305-6304/9/7/155acrylamidechildrendietepidemiological studieshumanssurveys and questionnaires |
| spellingShingle | Clara Amalie Gade Timmermann Signe Sonne Mølck Manik Kadawathagedara Anne Ahrendt Bjerregaard Margareta Törnqvist Anne Lise Brantsæter Marie Pedersen A Review of Dietary Intake of Acrylamide in Humans Toxics acrylamide children diet epidemiological studies humans surveys and questionnaires |
| title | A Review of Dietary Intake of Acrylamide in Humans |
| title_full | A Review of Dietary Intake of Acrylamide in Humans |
| title_fullStr | A Review of Dietary Intake of Acrylamide in Humans |
| title_full_unstemmed | A Review of Dietary Intake of Acrylamide in Humans |
| title_short | A Review of Dietary Intake of Acrylamide in Humans |
| title_sort | review of dietary intake of acrylamide in humans |
| topic | acrylamide children diet epidemiological studies humans surveys and questionnaires |
| url | https://www.mdpi.com/2305-6304/9/7/155 |
| work_keys_str_mv | AT claraamaliegadetimmermann areviewofdietaryintakeofacrylamideinhumans AT signesonnemølck areviewofdietaryintakeofacrylamideinhumans AT manikkadawathagedara areviewofdietaryintakeofacrylamideinhumans AT anneahrendtbjerregaard areviewofdietaryintakeofacrylamideinhumans AT margaretatornqvist areviewofdietaryintakeofacrylamideinhumans AT annelisebrantsæter areviewofdietaryintakeofacrylamideinhumans AT mariepedersen areviewofdietaryintakeofacrylamideinhumans AT claraamaliegadetimmermann reviewofdietaryintakeofacrylamideinhumans AT signesonnemølck reviewofdietaryintakeofacrylamideinhumans AT manikkadawathagedara reviewofdietaryintakeofacrylamideinhumans AT anneahrendtbjerregaard reviewofdietaryintakeofacrylamideinhumans AT margaretatornqvist reviewofdietaryintakeofacrylamideinhumans AT annelisebrantsæter reviewofdietaryintakeofacrylamideinhumans AT mariepedersen reviewofdietaryintakeofacrylamideinhumans |