Prognostic value of microRNAs in patients with small cell lung cancer: a meta-analysis

Abstract Background An increasing number of studies have shown that microRNAs play an important role in the occurrence and development of small cell lung cancer, which mainly manifest as oncogenic and tumor inhibition. Therefore, microRNAs may affect the survival of patients with small cell lung can...

Full description

Bibliographic Details
Main Authors: Jun Peng, Jinfeng Liu, Huining Liu, Yan Huang, Yingchun Ren
Format: Article
Language:English
Published: BMC 2022-12-01
Series:World Journal of Surgical Oncology
Subjects:
Online Access:https://doi.org/10.1186/s12957-022-02851-4
_version_ 1811204127787581440
author Jun Peng
Jinfeng Liu
Huining Liu
Yan Huang
Yingchun Ren
author_facet Jun Peng
Jinfeng Liu
Huining Liu
Yan Huang
Yingchun Ren
author_sort Jun Peng
collection DOAJ
description Abstract Background An increasing number of studies have shown that microRNAs play an important role in the occurrence and development of small cell lung cancer, which mainly manifest as oncogenic and tumor inhibition. Therefore, microRNAs may affect the survival of patients with small cell lung cancer. In this meta-analysis, we will evaluate the role of microRNAs in the overall survival of patients with small cell lung cancer, which may provide valuable information for the treatment of small cell lung cancer. Methods We searched the PubMed, Embase, and Web of Science online databases to determine the effect of microRNAs on the prognosis of patients with small cell lung cancer. The data and characteristics of each study were extracted, and the hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to estimate the effect. Results A total of 7 articles, involving 427 subjects and 15 studies, were included in this meta-analysis. The pooled HR of the relationship between the microRNA expression level and the overall survival rate of small cell lung cancer patients was 1.25 (95% CI: 1.06–1.47). There was a significant difference in the prognostic value of oncogenic and tumor inhibition microRNAs among patients with small cell lung cancer, with pooled HRs of 1.60 (95% CI: 1.35–1.90) and 0.42 (95% CI: 0.30–0.57), respectively. Conclusions MicroRNAs have a significant impact on the overall survival of small cell lung cancer patients, suggesting that microRNAs can be used as potential prognostic markers and may provide treatment strategies for small cell lung cancer patients. Trial registration The protocol was registered on PROSPERO website with the registration number of CRD42022334363. The relevant registration information can be obtained from the website https://www.crd.york.ac.uk/prospero/#searchadvanced .
first_indexed 2024-04-12T03:07:04Z
format Article
id doaj.art-6116189e178f430794e1da13ffb63e31
institution Directory Open Access Journal
issn 1477-7819
language English
last_indexed 2024-04-12T03:07:04Z
publishDate 2022-12-01
publisher BMC
record_format Article
series World Journal of Surgical Oncology
spelling doaj.art-6116189e178f430794e1da13ffb63e312022-12-22T03:50:28ZengBMCWorld Journal of Surgical Oncology1477-78192022-12-0120111110.1186/s12957-022-02851-4Prognostic value of microRNAs in patients with small cell lung cancer: a meta-analysisJun Peng0Jinfeng Liu1Huining Liu2Yan Huang3Yingchun Ren4Department of Thoracic Surgery, The First Hospital of Hebei Medical UniversityDepartment of Thoracic Surgery, The First Hospital of Hebei Medical UniversityDepartment of Thoracic Surgery, The First Hospital of Hebei Medical UniversityClinical Medical College of Jining Medical CollegeDepartment of Thoracic Surgery, The First Hospital of Hebei Medical UniversityAbstract Background An increasing number of studies have shown that microRNAs play an important role in the occurrence and development of small cell lung cancer, which mainly manifest as oncogenic and tumor inhibition. Therefore, microRNAs may affect the survival of patients with small cell lung cancer. In this meta-analysis, we will evaluate the role of microRNAs in the overall survival of patients with small cell lung cancer, which may provide valuable information for the treatment of small cell lung cancer. Methods We searched the PubMed, Embase, and Web of Science online databases to determine the effect of microRNAs on the prognosis of patients with small cell lung cancer. The data and characteristics of each study were extracted, and the hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to estimate the effect. Results A total of 7 articles, involving 427 subjects and 15 studies, were included in this meta-analysis. The pooled HR of the relationship between the microRNA expression level and the overall survival rate of small cell lung cancer patients was 1.25 (95% CI: 1.06–1.47). There was a significant difference in the prognostic value of oncogenic and tumor inhibition microRNAs among patients with small cell lung cancer, with pooled HRs of 1.60 (95% CI: 1.35–1.90) and 0.42 (95% CI: 0.30–0.57), respectively. Conclusions MicroRNAs have a significant impact on the overall survival of small cell lung cancer patients, suggesting that microRNAs can be used as potential prognostic markers and may provide treatment strategies for small cell lung cancer patients. Trial registration The protocol was registered on PROSPERO website with the registration number of CRD42022334363. The relevant registration information can be obtained from the website https://www.crd.york.ac.uk/prospero/#searchadvanced .https://doi.org/10.1186/s12957-022-02851-4Meta-analysisMicroRNAsSmall cell lung cancerPrognosis
spellingShingle Jun Peng
Jinfeng Liu
Huining Liu
Yan Huang
Yingchun Ren
Prognostic value of microRNAs in patients with small cell lung cancer: a meta-analysis
World Journal of Surgical Oncology
Meta-analysis
MicroRNAs
Small cell lung cancer
Prognosis
title Prognostic value of microRNAs in patients with small cell lung cancer: a meta-analysis
title_full Prognostic value of microRNAs in patients with small cell lung cancer: a meta-analysis
title_fullStr Prognostic value of microRNAs in patients with small cell lung cancer: a meta-analysis
title_full_unstemmed Prognostic value of microRNAs in patients with small cell lung cancer: a meta-analysis
title_short Prognostic value of microRNAs in patients with small cell lung cancer: a meta-analysis
title_sort prognostic value of micrornas in patients with small cell lung cancer a meta analysis
topic Meta-analysis
MicroRNAs
Small cell lung cancer
Prognosis
url https://doi.org/10.1186/s12957-022-02851-4
work_keys_str_mv AT junpeng prognosticvalueofmicrornasinpatientswithsmallcelllungcancerametaanalysis
AT jinfengliu prognosticvalueofmicrornasinpatientswithsmallcelllungcancerametaanalysis
AT huiningliu prognosticvalueofmicrornasinpatientswithsmallcelllungcancerametaanalysis
AT yanhuang prognosticvalueofmicrornasinpatientswithsmallcelllungcancerametaanalysis
AT yingchunren prognosticvalueofmicrornasinpatientswithsmallcelllungcancerametaanalysis