Targeting 17β-estradiol biosynthesis in neural stem cells improves stroke outcome

Targeting 17β-estradiol biosynthesis in neural stem cells improves stroke outcome

Dax-1 (dosage-sensitive sex reversal adrenal hypoplasia congenital region on X-chromosome gene 1) blocks 17β-estradiol biosynthesis and its knockdown would be expected to increase 17β-estradiol production. We hypothesized that knockdown of Dax-1 in a conditionally immortalized neural stem cell (NSC)...

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Bibliographic Details
Main Authors: Shalmali Patkar, Dafe Uwanogho, Michel Modo, Rothwelle J. Tate, Robin Plevin, Hilary V. O. Carswell
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
cerebral ischemia
estrogen
steroidogenesis
cell therapy
transplantation
neuroprotection
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.917181/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.917181/full

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