| Summary: | The influence of certain anticoccidial drugs on oxidative stress in broiler chickens infected with Eimeria species was assessed. There were two
untreated (uninfected and infected), and three groups infected and treated with anticoccidials. The first treated group (Ro) was given robenidine,
the 2nd a herbal anticoccidial (Herb) and the 3rd the combination of robenidine and the herbal anticoccidial (Ro+Herb). All infected groups were on
day 14 challenged with oral inoculation of oocysts. The activities of catalase (CAT), superoxide dismutase (SOD) and glutathione S-transferase (GST),
and the concentration of malondialdehyde (MDA) were estimated in blood taken on days 21 and 40. The oocyst numbers were calculated per gram,
and chicken body weight and feed conversion ratio (FCR) measured. The activities of CAT, GST and the level of MDA were significantly lower (P<0.05),
whilst the activity of SOD was higher in infected chickens treated with anticoccidials (P<0.05) in comparison to those untreated. The most prominent
change in the parameters of oxidative stress was recorded in the Ro+Herb group. In chickens treated with anticoccidials body weight was significantly
higher (P<0.05), and the FCR and the oocyst counts significantly lower (P<0.05) than in untreated chickens. Oocyst counts were lower in the Ro and
Ro+Herb groups than in the Herb group. Our study demonstrated that both anticoccidial substances exerted antioxidant and anticoccidial effects.
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