A Progress on the Application of Tetrodotoxin
Tetrodotoxin (TTX), a blocker of sodium channels, exists in the pufferfish, amphibians, and octopus, and originated in endosymbiont-vibrio. Researches have confirmed that TTX affected the action potential through the regulation of voltage-gated sodium channels (VGSCs) and the ingestion of TTX inhibi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
EDP Sciences
2021-01-01
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| Series: | E3S Web of Conferences |
| Online Access: | https://www.e3s-conferences.org/articles/e3sconf/pdf/2021/68/e3sconf_netid21_03065.pdf |
| _version_ | 1818573470429085696 |
|---|---|
| author | Wang Zhaojia Zhou Zhenning |
| author_facet | Wang Zhaojia Zhou Zhenning |
| author_sort | Wang Zhaojia |
| collection | DOAJ |
| description | Tetrodotoxin (TTX), a blocker of sodium channels, exists in the pufferfish, amphibians, and octopus, and originated in endosymbiont-vibrio. Researches have confirmed that TTX affected the action potential through the regulation of voltage-gated sodium channels (VGSCs) and the ingestion of TTX inhibits the nerve signal’s transmission, showing symptoms like rapid weakening and paralysis of the muscles. Recent research shows that TTX’s medical value as the analgesic is mainly focused. The comparison on efficacy among placebo, TTX, and opioids manifests that TTX is healthy and effective in treating neuropathic pain. Moreover, since the drug is synthesized by TTX, it can block specific neurons to alleviate the pain on different parts of the body accurately. Currently speaking, TTX has been widely used as medicine for the alleviation of cancer pain. The mechanism, symptoms, application, and treatment are thoroughly discussed to popularize TTX and pass the “torch” to the new generation because there is still a long way to go—the unsolved mysteries of TTX awaiting humans. |
| first_indexed | 2024-12-15T00:11:45Z |
| format | Article |
| id | doaj.art-611986947b4247fca5fabfccd10bf610 |
| institution | Directory Open Access Journal |
| issn | 2267-1242 |
| language | English |
| last_indexed | 2024-12-15T00:11:45Z |
| publishDate | 2021-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | E3S Web of Conferences |
| spelling | doaj.art-611986947b4247fca5fabfccd10bf6102022-12-21T22:42:33ZengEDP SciencesE3S Web of Conferences2267-12422021-01-012920306510.1051/e3sconf/202129203065e3sconf_netid21_03065A Progress on the Application of TetrodotoxinWang Zhaojia0Zhou Zhenning1St. Jude’s AcademyJustin Siena High SchoolTetrodotoxin (TTX), a blocker of sodium channels, exists in the pufferfish, amphibians, and octopus, and originated in endosymbiont-vibrio. Researches have confirmed that TTX affected the action potential through the regulation of voltage-gated sodium channels (VGSCs) and the ingestion of TTX inhibits the nerve signal’s transmission, showing symptoms like rapid weakening and paralysis of the muscles. Recent research shows that TTX’s medical value as the analgesic is mainly focused. The comparison on efficacy among placebo, TTX, and opioids manifests that TTX is healthy and effective in treating neuropathic pain. Moreover, since the drug is synthesized by TTX, it can block specific neurons to alleviate the pain on different parts of the body accurately. Currently speaking, TTX has been widely used as medicine for the alleviation of cancer pain. The mechanism, symptoms, application, and treatment are thoroughly discussed to popularize TTX and pass the “torch” to the new generation because there is still a long way to go—the unsolved mysteries of TTX awaiting humans.https://www.e3s-conferences.org/articles/e3sconf/pdf/2021/68/e3sconf_netid21_03065.pdf |
| spellingShingle | Wang Zhaojia Zhou Zhenning A Progress on the Application of Tetrodotoxin E3S Web of Conferences |
| title | A Progress on the Application of Tetrodotoxin |
| title_full | A Progress on the Application of Tetrodotoxin |
| title_fullStr | A Progress on the Application of Tetrodotoxin |
| title_full_unstemmed | A Progress on the Application of Tetrodotoxin |
| title_short | A Progress on the Application of Tetrodotoxin |
| title_sort | progress on the application of tetrodotoxin |
| url | https://www.e3s-conferences.org/articles/e3sconf/pdf/2021/68/e3sconf_netid21_03065.pdf |
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