Metabolites Alterations in the Medial Prefrontal Cortex of Methamphetamine Users in Abstinence: A 1H MRS Study
Background: The medial prefrontal cortex (mPFC) contains various neurotransmitter systems and plays an important role in drug use. Broad body of literature on how methamphetamine (MA) affects the structure and metabolism in the animal's mPFC is emerging, while the effects on metabolites of mPFC...
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Frontiers Media S.A.
2018-10-01
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2018.00478/full |
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| author | Qiuxia Wu Qiuxia Wu Qiuxia Wu Qiuxia Wu Qiuxia Wu Qiuxia Wu Qiuxia Wu Chang Qi Chang Qi Chang Qi Chang Qi Chang Qi Chang Qi Jiang Long Jiang Long Jiang Long Jiang Long Jiang Long Jiang Long Yanhui Liao Yanhui Liao Yanhui Liao Yanhui Liao Yanhui Liao Yanhui Liao Xuyi Wang Xuyi Wang Xuyi Wang Xuyi Wang Xuyi Wang Xuyi Wang An Xie Jianbin Liu Wei Hao Wei Hao Wei Hao Wei Hao Wei Hao Wei Hao Yiyuan Tang Baozhu Yang Tieqiao Liu Tieqiao Liu Tieqiao Liu Tieqiao Liu Tieqiao Liu Tieqiao Liu Jinsong Tang Jinsong Tang Jinsong Tang Jinsong Tang Jinsong Tang Jinsong Tang |
| author_facet | Qiuxia Wu Qiuxia Wu Qiuxia Wu Qiuxia Wu Qiuxia Wu Qiuxia Wu Qiuxia Wu Chang Qi Chang Qi Chang Qi Chang Qi Chang Qi Chang Qi Jiang Long Jiang Long Jiang Long Jiang Long Jiang Long Jiang Long Yanhui Liao Yanhui Liao Yanhui Liao Yanhui Liao Yanhui Liao Yanhui Liao Xuyi Wang Xuyi Wang Xuyi Wang Xuyi Wang Xuyi Wang Xuyi Wang An Xie Jianbin Liu Wei Hao Wei Hao Wei Hao Wei Hao Wei Hao Wei Hao Yiyuan Tang Baozhu Yang Tieqiao Liu Tieqiao Liu Tieqiao Liu Tieqiao Liu Tieqiao Liu Tieqiao Liu Jinsong Tang Jinsong Tang Jinsong Tang Jinsong Tang Jinsong Tang Jinsong Tang |
| author_sort | Qiuxia Wu |
| collection | DOAJ |
| description | Background: The medial prefrontal cortex (mPFC) contains various neurotransmitter systems and plays an important role in drug use. Broad body of literature on how methamphetamine (MA) affects the structure and metabolism in the animal's mPFC is emerging, while the effects on metabolites of mPFC among human is still unclear. In this study, proton magnetic resonance spectroscopy (1H MRS) was used to measure metabolites of mPFC in methamphetamine dependent subjects.Methods: Sixty-one subjects with a history of MA dependence (fulfiled the Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria) and 65 drug-naïve control subjects (age19–45) completed 1H MRS scans using 3.0T Siemens MRI scanner. Single voxel spectra were acquired from the mPFC bilaterally using a point resolved spectroscopy sequence (PRESS). The 1H MRS data were automatically fit with linear combination model for quantification of metabolite levels of n-acetyl-aspartate (NAA), myo-inositol (mI), glycerophosphocholine plus phosphocholine(GPC+PC), phosphocreatine plus creatine (PCr+Cr), and glutamate (Glu). Metabolite levels were reported as ratios to PCr+Cr.Results: The MA group showed a significant reduction in NAA/PCr+Cr ratio and elevation in Glu/PCr+Cr ratio and mI/PCr+Cr ratio, compared with healthy control. No significant correlation was found between metabolite ratios and MA use variables.Conclusions: MA use is associated with a significant increased Glu/PCr+Cr ratio, mI/PCr+Cr ratio and reduced NAA/PCr+Cr ratio in the mPFC of MA dependence subjects. These findings suggest that Glu may play a key role in MA induced neurotoxicity. |
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| spelling | doaj.art-6119a923031a4bfeac0ba982227d65722022-12-22T00:42:13ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402018-10-01910.3389/fpsyt.2018.00478395072Metabolites Alterations in the Medial Prefrontal Cortex of Methamphetamine Users in Abstinence: A 1H MRS StudyQiuxia Wu0Qiuxia Wu1Qiuxia Wu2Qiuxia Wu3Qiuxia Wu4Qiuxia Wu5Qiuxia Wu6Chang Qi7Chang Qi8Chang Qi9Chang Qi10Chang Qi11Chang Qi12Jiang Long13Jiang Long14Jiang Long15Jiang Long16Jiang Long17Jiang Long18Yanhui Liao19Yanhui Liao20Yanhui Liao21Yanhui Liao22Yanhui Liao23Yanhui Liao24Xuyi Wang25Xuyi Wang26Xuyi Wang27Xuyi Wang28Xuyi Wang29Xuyi Wang30An Xie31Jianbin Liu32Wei Hao33Wei Hao34Wei Hao35Wei Hao36Wei Hao37Wei Hao38Yiyuan Tang39Baozhu Yang40Tieqiao Liu41Tieqiao Liu42Tieqiao Liu43Tieqiao Liu44Tieqiao Liu45Tieqiao Liu46Jinsong Tang47Jinsong Tang48Jinsong Tang49Jinsong Tang50Jinsong Tang51Jinsong Tang52Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute, The Second Xiangya Hospital, Central South University, Changsha, ChinaChinese National Clinical Research Center on Mental Disorders, Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center on Mental Disorders, Changsha, ChinaNational Technology Institute on Mental Disorders, Changsha, ChinaHunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychological Sciences, Texas Tech University, Lubbock, TX, United StatesDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute, The Second Xiangya Hospital, Central South University, Changsha, ChinaChinese National Clinical Research Center on Mental Disorders, Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center on Mental Disorders, Changsha, ChinaNational Technology Institute on Mental Disorders, Changsha, ChinaHunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute, The Second Xiangya Hospital, Central South University, Changsha, ChinaChinese National Clinical Research Center on Mental Disorders, Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center on Mental Disorders, Changsha, ChinaNational Technology Institute on Mental Disorders, Changsha, ChinaHunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute, The Second Xiangya Hospital, Central South University, Changsha, ChinaChinese National Clinical Research Center on Mental Disorders, Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center on Mental Disorders, Changsha, ChinaNational Technology Institute on Mental Disorders, Changsha, ChinaHunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute, The Second Xiangya Hospital, Central South University, Changsha, ChinaChinese National Clinical Research Center on Mental Disorders, Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center on Mental Disorders, Changsha, ChinaNational Technology Institute on Mental Disorders, Changsha, ChinaHunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Radiology, Hunan Provincial People's Hospital, Changsha, ChinaDepartment of Radiology, Hunan Provincial People's Hospital, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute, The Second Xiangya Hospital, Central South University, Changsha, ChinaChinese National Clinical Research Center on Mental Disorders, Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center on Mental Disorders, Changsha, ChinaNational Technology Institute on Mental Disorders, Changsha, ChinaHunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychological Sciences, Texas Tech University, Lubbock, TX, United StatesDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, United StatesDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute, The Second Xiangya Hospital, Central South University, Changsha, ChinaChinese National Clinical Research Center on Mental Disorders, Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center on Mental Disorders, Changsha, ChinaNational Technology Institute on Mental Disorders, Changsha, ChinaHunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute, The Second Xiangya Hospital, Central South University, Changsha, ChinaChinese National Clinical Research Center on Mental Disorders, Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center on Mental Disorders, Changsha, ChinaNational Technology Institute on Mental Disorders, Changsha, ChinaHunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaBackground: The medial prefrontal cortex (mPFC) contains various neurotransmitter systems and plays an important role in drug use. Broad body of literature on how methamphetamine (MA) affects the structure and metabolism in the animal's mPFC is emerging, while the effects on metabolites of mPFC among human is still unclear. In this study, proton magnetic resonance spectroscopy (1H MRS) was used to measure metabolites of mPFC in methamphetamine dependent subjects.Methods: Sixty-one subjects with a history of MA dependence (fulfiled the Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria) and 65 drug-naïve control subjects (age19–45) completed 1H MRS scans using 3.0T Siemens MRI scanner. Single voxel spectra were acquired from the mPFC bilaterally using a point resolved spectroscopy sequence (PRESS). The 1H MRS data were automatically fit with linear combination model for quantification of metabolite levels of n-acetyl-aspartate (NAA), myo-inositol (mI), glycerophosphocholine plus phosphocholine(GPC+PC), phosphocreatine plus creatine (PCr+Cr), and glutamate (Glu). Metabolite levels were reported as ratios to PCr+Cr.Results: The MA group showed a significant reduction in NAA/PCr+Cr ratio and elevation in Glu/PCr+Cr ratio and mI/PCr+Cr ratio, compared with healthy control. No significant correlation was found between metabolite ratios and MA use variables.Conclusions: MA use is associated with a significant increased Glu/PCr+Cr ratio, mI/PCr+Cr ratio and reduced NAA/PCr+Cr ratio in the mPFC of MA dependence subjects. These findings suggest that Glu may play a key role in MA induced neurotoxicity.https://www.frontiersin.org/article/10.3389/fpsyt.2018.00478/fullmethamphetaminemPFNAA/PCr+CrGlu/PCr+CrmI/PCr+Cr1H MRS |
| spellingShingle | Qiuxia Wu Qiuxia Wu Qiuxia Wu Qiuxia Wu Qiuxia Wu Qiuxia Wu Qiuxia Wu Chang Qi Chang Qi Chang Qi Chang Qi Chang Qi Chang Qi Jiang Long Jiang Long Jiang Long Jiang Long Jiang Long Jiang Long Yanhui Liao Yanhui Liao Yanhui Liao Yanhui Liao Yanhui Liao Yanhui Liao Xuyi Wang Xuyi Wang Xuyi Wang Xuyi Wang Xuyi Wang Xuyi Wang An Xie Jianbin Liu Wei Hao Wei Hao Wei Hao Wei Hao Wei Hao Wei Hao Yiyuan Tang Baozhu Yang Tieqiao Liu Tieqiao Liu Tieqiao Liu Tieqiao Liu Tieqiao Liu Tieqiao Liu Jinsong Tang Jinsong Tang Jinsong Tang Jinsong Tang Jinsong Tang Jinsong Tang Metabolites Alterations in the Medial Prefrontal Cortex of Methamphetamine Users in Abstinence: A 1H MRS Study Frontiers in Psychiatry methamphetamine mPF NAA/PCr+Cr Glu/PCr+Cr mI/PCr+Cr 1H MRS |
| title | Metabolites Alterations in the Medial Prefrontal Cortex of Methamphetamine Users in Abstinence: A 1H MRS Study |
| title_full | Metabolites Alterations in the Medial Prefrontal Cortex of Methamphetamine Users in Abstinence: A 1H MRS Study |
| title_fullStr | Metabolites Alterations in the Medial Prefrontal Cortex of Methamphetamine Users in Abstinence: A 1H MRS Study |
| title_full_unstemmed | Metabolites Alterations in the Medial Prefrontal Cortex of Methamphetamine Users in Abstinence: A 1H MRS Study |
| title_short | Metabolites Alterations in the Medial Prefrontal Cortex of Methamphetamine Users in Abstinence: A 1H MRS Study |
| title_sort | metabolites alterations in the medial prefrontal cortex of methamphetamine users in abstinence a 1h mrs study |
| topic | methamphetamine mPF NAA/PCr+Cr Glu/PCr+Cr mI/PCr+Cr 1H MRS |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2018.00478/full |
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