Exploring mitochondrial hydrogen sulfide signalling for therapeutic interventions in vascular diseases
Hydrogen sulfide (H2S), a gaseous signalling molecule, is important in numerous physiological and pathophysiological processes. Despite its initial identification as an environmental toxin, H2S is now well described as an essential physiological molecule that is finely balanced to maintain cellular...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-04-01
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| Series: | Advances in Redox Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667137922000029 |
| _version_ | 1819003307749801984 |
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| author | Lorena Diaz Sanchez Lissette Sanchez-Aranguren Mandeep Marwah Keqing Wang Corinne M Spickett Helen R Griffiths Irundika HK Dias |
| author_facet | Lorena Diaz Sanchez Lissette Sanchez-Aranguren Mandeep Marwah Keqing Wang Corinne M Spickett Helen R Griffiths Irundika HK Dias |
| author_sort | Lorena Diaz Sanchez |
| collection | DOAJ |
| description | Hydrogen sulfide (H2S), a gaseous signalling molecule, is important in numerous physiological and pathophysiological processes. Despite its initial identification as an environmental toxin, H2S is now well described as an essential physiological molecule that is finely balanced to maintain cellular functions, especially in modulating mitochondrial activity. Mitochondria are responsible for the oxidation of H2S and its safe elimination while maintaining mitochondrial biogenesis. H2S oxidation in mitochondria generates various reactive sulfur species that could post-translationally modify proteins by sulfhydration. Sulfhydrated proteins participate in many regulatory activities either by direct interactions in the electron transport chain or indirect regulation by epigenetics. These investigations explain the importance of research of H2S as a therapeutic molecule beyond the traditional understanding as a protective role through its anti-inflammatory and antioxidant properties. This review focuses on highlighting the significant involvement of the H2S pathway in vascular diseases and current H2S donors for therapeutic use under development. |
| first_indexed | 2024-12-20T23:18:56Z |
| format | Article |
| id | doaj.art-611ade58d25a488f89c5e4e0e2f83420 |
| institution | Directory Open Access Journal |
| issn | 2667-1379 |
| language | English |
| last_indexed | 2024-12-20T23:18:56Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Redox Research |
| spelling | doaj.art-611ade58d25a488f89c5e4e0e2f834202022-12-21T19:23:35ZengElsevierAdvances in Redox Research2667-13792022-04-014100030Exploring mitochondrial hydrogen sulfide signalling for therapeutic interventions in vascular diseasesLorena Diaz Sanchez0Lissette Sanchez-Aranguren1Mandeep Marwah2Keqing Wang3Corinne M Spickett4Helen R Griffiths5Irundika HK Dias6Aston Medical School, College of Health and Life Sciences, Aston University, UKAston Medical School, College of Health and Life Sciences, Aston University, UKAston Medical School, College of Health and Life Sciences, Aston University, UKAston Medical School, College of Health and Life Sciences, Aston University, UKSchool of Biosciences, College of Health and Life Sciences, Aston University, UKSwansea University Medical School, Swansea University, Swansea, UKAston Medical School, College of Health and Life Sciences, Aston University, UK; Corresponding author.Hydrogen sulfide (H2S), a gaseous signalling molecule, is important in numerous physiological and pathophysiological processes. Despite its initial identification as an environmental toxin, H2S is now well described as an essential physiological molecule that is finely balanced to maintain cellular functions, especially in modulating mitochondrial activity. Mitochondria are responsible for the oxidation of H2S and its safe elimination while maintaining mitochondrial biogenesis. H2S oxidation in mitochondria generates various reactive sulfur species that could post-translationally modify proteins by sulfhydration. Sulfhydrated proteins participate in many regulatory activities either by direct interactions in the electron transport chain or indirect regulation by epigenetics. These investigations explain the importance of research of H2S as a therapeutic molecule beyond the traditional understanding as a protective role through its anti-inflammatory and antioxidant properties. This review focuses on highlighting the significant involvement of the H2S pathway in vascular diseases and current H2S donors for therapeutic use under development.http://www.sciencedirect.com/science/article/pii/S2667137922000029Hydrogen SulfideMitochondriaEndothelial cellsSulfhydrationVascular diseaseSignalling |
| spellingShingle | Lorena Diaz Sanchez Lissette Sanchez-Aranguren Mandeep Marwah Keqing Wang Corinne M Spickett Helen R Griffiths Irundika HK Dias Exploring mitochondrial hydrogen sulfide signalling for therapeutic interventions in vascular diseases Advances in Redox Research Hydrogen Sulfide Mitochondria Endothelial cells Sulfhydration Vascular disease Signalling |
| title | Exploring mitochondrial hydrogen sulfide signalling for therapeutic interventions in vascular diseases |
| title_full | Exploring mitochondrial hydrogen sulfide signalling for therapeutic interventions in vascular diseases |
| title_fullStr | Exploring mitochondrial hydrogen sulfide signalling for therapeutic interventions in vascular diseases |
| title_full_unstemmed | Exploring mitochondrial hydrogen sulfide signalling for therapeutic interventions in vascular diseases |
| title_short | Exploring mitochondrial hydrogen sulfide signalling for therapeutic interventions in vascular diseases |
| title_sort | exploring mitochondrial hydrogen sulfide signalling for therapeutic interventions in vascular diseases |
| topic | Hydrogen Sulfide Mitochondria Endothelial cells Sulfhydration Vascular disease Signalling |
| url | http://www.sciencedirect.com/science/article/pii/S2667137922000029 |
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