Synthesis and Comparative Evaluation of Novel Cationic Amphiphile C12-Man-Q as an Efficient DNA Delivery Agent In Vitro

Synthesis and Comparative Evaluation of Novel Cationic Amphiphile C12-Man-Q as an Efficient DNA Delivery Agent In Vitro

New amphiphilic 1,4-DHP derivative C12-Man-Q with remoted cationic moieties at positions 2 and 6 was synthesised to study DNA delivery activity. The results were compared with data obtained for cationic 1,4-DHP derivative D19, which is known to be the most efficient one among the previously tested 1...

Full description

Bibliographic Details
Main Authors:	Gunita Apsite, Irena Timofejeva, Aleksandra Vezane, Brigita Vigante, Martins Rucins, Arkadij Sobolev, Mara Plotniece, Karlis Pajuste, Tatjana Kozlovska, Aiva Plotniece
Format:	Article
Language:	English
Published:	MDPI AG 2018-06-01
Series:	Molecules
Subjects:	cationic amphiphiles 1,4-dihydropyridines lipoplexes DNA transfection gene delivery cytotoxicity
Online Access:	http://www.mdpi.com/1420-3049/23/7/1540

Similar Items

Synthesis and Characterization of Novel Amphiphilic <i>N</i>-Benzyl 1,4-Dihydropyridine Derivatives—Evaluation of Lipid Monolayer and Self-Assembling Properties
by: Anna Krapivina, et al.
Published: (2023-06-01)

Evaluation of Physicochemical Properties of Amphiphilic 1,4-Dihydropyridines and Preparation of Magnetoliposomes
by: Oksana Petrichenko, et al.
Published: (2021-02-01)

Data for the cytotoxicity, self-assembling properties and synthesis of 4-pyridinium-1,4-dihydropyridines
by: Klavs Pajuste, et al.
Published: (2020-12-01)

Development of Self-Assembling <i>bis</i>-1,4-Dihydropyridines: Detailed Studies of Bromination of Four Methyl Groups and Bromine Nucleophilic Substitution
by: Martins Kaukulis, et al.
Published: (2023-12-01)

1,1′-{[3,5-Bis((dodecyloxycarbonyl)-4-phenyl-1,4-dihydropyridine-2,6-diyl]bis(methylene)}bis[4-(anthracen-9-yl)pyridin-1-ium] Dibromide
by: Reinis Ozolins, et al.
Published: (2022-09-01)

1,1′-{[3,5-Bis(dodecyloxycarbonyl)-4-(naphthalen-2-yl)-1,4-dihydropyridine-2,6-diyl]bis(methylene)}bis{4-[(<i>E</i>)-2-(naphthalen-2-yl)vinyl]pyridin-1-ium}dibromide
by: Martins Rucins, et al.
Published: (2022-06-01)

Synthesis and Characterisation of 1,1′-{[3,5-Bis(dodecyloxy-carbonyl)-4-(thiophen-3-yl)-1,4-dihydropyridine-2,6-diyl]bis-(methylene)}bis(pyridin-1-ium) Dibromide
by: Martins Rucins, et al.
Published: (2021-12-01)

Synthesis of Fluorinated 3,6-Dihydropyridines and 2-(Fluoromethyl)pyridines by Electrophilic Fluorination of 1,2-Dihydropyridines with Selectfluor<sup>®</sup>
by: Nadiia V. Pikun, et al.
Published: (2020-07-01)

Direct Aminolysis of Ethoxycarbonylmethyl 1,4-Dihydropyridine-3-carboxylates
by: Brigita Vigante, et al.
Published: (2015-11-01)

Cationic amphiphiles based on malonic acid amides as transfection mediators
by: N. A. Romanova, et al.
Published: (2020-11-01)

Use of pyridinium ionic liquids as catalysts for the synthesis of 3,5-bis(dodecyloxycarbonyl)-1,4-dihydropyridine derivative
by: Pajuste Karlis, et al.
Published: (2011-02-01)

Cationic Single-Chained Surfactants with a Functional Group at the End of the Hydrophobic Tail DNA Compacting Efficiency
by: José Antonio Lebrón, et al.
Published: (2021-04-01)

Amphiphilic Copolymer-Lipid Chimeric Nanosystems as DNA Vectors
by: Varvara Chrysostomou, et al.
Published: (2022-11-01)

Recent Approaches to Chiral 1,4-Dihydropyridines and their Fused Analogues
by: Martins Rucins, et al.
Published: (2020-09-01)

Synthesis and Evaluation of Self-Assembling Properties of 3-(3,5-Difluoro-3,5-bis((alkoxy)carbonyl)-2,6-dioxoheptan-4-yl)-1-methylpyridin-1-ium Iodides
by: Nadiia Pikun, et al.
Published: (2022-07-01)

mRNA Lipoplexes with Cationic and Ionizable α-Amino-lipophosphonates: Membrane Fusion, Transfection, mRNA Translation and Conformation
by: Sohail Akhter, et al.
Published: (2022-03-01)

Cationic Liposomes Modified with Polyallylamine as a Gene Carrier: Preparation, Characterization and Transfection Efficiency Evaluation
by: Reza Kazemi Oskuee, et al.
Published: (2016-12-01)

Intramolecular C-H···O Hydrogen Bonding in 1,4-Dihydropyridine Derivatives
by: Brigita Cekavicus, et al.
Published: (2011-09-01)

Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency
by: Helena Sork, et al.
Published: (2016-01-01)

Synthesis of polycationic amphiphiles on the basis of cholic acid
by: V. N. Sokolik, et al.
Published: (2010-12-01)

Design and Synthesis of Hepatitis B Virus (HBV) Capsid Assembly Modulators and Evaluation of Their Activity in Mammalian Cell Model
by: Karina Spunde, et al.
Published: (2022-06-01)

Synthesis and Characterization of Radiogallium-Labeled Cationic Amphiphilic Peptides as Tumor Imaging Agents
by: Takeshi Fuchigami, et al.
Published: (2021-05-01)

A Cationic Amphiphilic AIE Polymer for Mitochondrial Targeting and Imaging
by: Junliang Zhou, et al.
Published: (2022-12-01)

Sodium <i>N</i>-(3,5-Bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-4-carbonyl)-<span style="font-variant: small-caps">l</span>-methioninate
by: Egils Bisenieks, et al.
Published: (2020-07-01)

Preparation of Cationic Amphiphilic Nanoparticles with Modified Chitosan Derivatives for Doxorubicin Delivery
by: Xiudong Liu, et al.
Published: (2021-11-01)

Different Sensitivity of Macrophages to Phospholipidosis Induction by Amphiphilic Cationic Drugs
by: Kristin Öhlinger, et al.
Published: (2020-11-01)

Flavonoids Enhance Lipofection Efficiency and Ameliorate Cytotoxicity in Colon26 and HepG2 Cells via Oxidative Stress Regulation
by: Die Hu, et al.
Published: (2022-06-01)

Lipothioureas as Lipids for Gene Transfection: A Review
by: Jean Herscovici, et al.
Published: (2011-10-01)

Self‐reporting fluorescence deciphers the antibacterial nature of cationic amphiphiles: Monomer or aggregate?
by: Chengcheng Zhou, et al.
Published: (2023-10-01)

Visual tracing of diffusion and biodistribution for amphiphilic cationic nanoparticles using photoacoustic imaging after ex vivo intravitreal injections
by: Xu X, et al.
Published: (2016-10-01)

Synthesis and Antibacterial Activities of Amphiphilic Neomycin B-based Bilipid Conjugates and Fluorinated Neomycin B-based Lipids
by: Frank Schweizer, et al.
Published: (2012-08-01)

Random Copolymers of Lysine and Isoleucine for Efficient mRNA Delivery
by: Iuliia Pilipenko, et al.
Published: (2022-05-01)

A molecular view on the escape of lipoplexed DNA from the endosome
by: Bart MH Bruininks, et al.
Published: (2020-04-01)

Barriers and Strategies of Cationic Liposomes for Cancer Gene Therapy
by: Chunyan Liu, et al.
Published: (2020-09-01)

DNA Vaccine Administered by Cationic Lipoplexes or by In Vivo Electroporation Induces Comparable Antibody Responses against SARS-CoV-2 in Mice
by: Allegra Peletta, et al.
Published: (2021-08-01)

Novel amphiphilic pyridinium ionic liquids-supported Schiff bases: ultrasound assisted synthesis, molecular docking and anticancer evaluation
by: Fawzia Faleh Al-Blewi, et al.
Published: (2018-11-01)

Calcium enhances polyplex-mediated transfection efficiency of plasmid DNA in Jurkat cells
by: V. S. S. Abhinav Ayyadevara, et al.
Published: (2020-01-01)

Contribution of Molecular Structure to Self-Assembling and Biological Properties of Bifunctional Lipid-Like 4-(N-Alkylpyridinium)-1,4-Dihydropyridines
by: Martins Rucins, et al.
Published: (2019-03-01)

Evaluation of the Efficiency of Random and Diblock Methacrylate-Based Amphiphilic Cationic Polymers against Major Bacterial Pathogens Associated with Cystic Fibrosis
by: Magali Casanova, et al.
Published: (2023-01-01)

Photodynamic Inhibition of Herpes Simplex Virus 1 Infection by Tricationic Amphiphilic Porphyrin with a Long Alkyl Chain
by: Igor Jurak, et al.
Published: (2023-03-01)