CPAP Therapy on Depressive and Anxiety Symptoms in Patients with Moderate to Severe Obstructive Sleep Apnea Syndrome
<i>Backgrounds and Objectives:</i> There is a link between sleep apnea syndrome (OSA) and depressive and anxiety symptoms, but the underlying mechanisms are not fully understood. The study aimed to determine the prevalence of these symptoms in patients with OSA and to evaluate the impact...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/10/1402 |
| _version_ | 1827649025839464448 |
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| author | Diana Raluca Velescu Monica Marc Diana Manolescu Daniel Trăilă Cristian Oancea |
| author_facet | Diana Raluca Velescu Monica Marc Diana Manolescu Daniel Trăilă Cristian Oancea |
| author_sort | Diana Raluca Velescu |
| collection | DOAJ |
| description | <i>Backgrounds and Objectives:</i> There is a link between sleep apnea syndrome (OSA) and depressive and anxiety symptoms, but the underlying mechanisms are not fully understood. The study aimed to determine the prevalence of these symptoms in patients with OSA and to evaluate the impact of continuous positive airway pressure (CPAP) on depression and anxiety scores. <i>Materials and Methods:</i> Ninety-nine consecutive new patients diagnosed with moderate or severe (apnea-hypopnea index AHI ≥ 15 events/h) OSA were accepted for the CPAP therapy. Patients completed a patient health questionnaire (PHQ-9) for depressive symptoms and a generalized anxiety questionnaire (GAD-7) for anxiety symptoms before the CPAP treatment, after 6 months, and after 1 year of CPAP therapy with compliance. For both scores (PHQ-9 and GAD-7), a cut point ≥10 was used to indicate the presence of clinically depressive and anxiety symptoms. <i>Results:</i> Forty-eight individuals (48.48%) had PHQ-9 scores above the cut-off point ≥ 10, and twenty-seven participants (27.27%) had GAD-7 scores above the cut-off point ≥10. A significant correlation has been shown between PHQ-9 score and BMI (<i>p</i> < 0.0001), AHI (<i>p</i> < 0.0001), ODI (<i>p</i> < 0.001), ESS (<i>p</i> < 0.001), GAD-7 score (<i>p</i> < 0.0001), and [t90] (<i>p</i> < 0.0001), while GAD-7 was correlated with AHI (<i>p</i> < 0.030), ODI (<i>p</i> < 0.006), and [t90] (<i>p</i> < 0.001). The PHQ-9 and GAD-7 scores decreased significantly after 6 months of CPAP therapy in all groups and after 1 year of CPAP use. <i>Conclusions:</i> OSA patients should be screened for depression and anxiety. Furthermore, CPAP should be the first choice of treatment before starting other treatments for depression and anxiety symptoms. |
| first_indexed | 2024-03-09T19:51:11Z |
| format | Article |
| id | doaj.art-611dc064981c4fd89d0a6c7723c6234c |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T19:51:11Z |
| publishDate | 2022-10-01 |
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| series | Medicina |
| spelling | doaj.art-611dc064981c4fd89d0a6c7723c6234c2023-11-24T01:10:31ZengMDPI AGMedicina1010-660X1648-91442022-10-015810140210.3390/medicina58101402CPAP Therapy on Depressive and Anxiety Symptoms in Patients with Moderate to Severe Obstructive Sleep Apnea SyndromeDiana Raluca Velescu0Monica Marc1Diana Manolescu2Daniel Trăilă3Cristian Oancea4Center for Research and Innovation in Precision Medicine of Respiratory Diseases, ”Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaCenter for Research and Innovation in Precision Medicine of Respiratory Diseases, ”Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaDepartment of Radiology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaCenter for Research and Innovation in Precision Medicine of Respiratory Diseases, ”Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaCenter for Research and Innovation in Precision Medicine of Respiratory Diseases, ”Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania<i>Backgrounds and Objectives:</i> There is a link between sleep apnea syndrome (OSA) and depressive and anxiety symptoms, but the underlying mechanisms are not fully understood. The study aimed to determine the prevalence of these symptoms in patients with OSA and to evaluate the impact of continuous positive airway pressure (CPAP) on depression and anxiety scores. <i>Materials and Methods:</i> Ninety-nine consecutive new patients diagnosed with moderate or severe (apnea-hypopnea index AHI ≥ 15 events/h) OSA were accepted for the CPAP therapy. Patients completed a patient health questionnaire (PHQ-9) for depressive symptoms and a generalized anxiety questionnaire (GAD-7) for anxiety symptoms before the CPAP treatment, after 6 months, and after 1 year of CPAP therapy with compliance. For both scores (PHQ-9 and GAD-7), a cut point ≥10 was used to indicate the presence of clinically depressive and anxiety symptoms. <i>Results:</i> Forty-eight individuals (48.48%) had PHQ-9 scores above the cut-off point ≥ 10, and twenty-seven participants (27.27%) had GAD-7 scores above the cut-off point ≥10. A significant correlation has been shown between PHQ-9 score and BMI (<i>p</i> < 0.0001), AHI (<i>p</i> < 0.0001), ODI (<i>p</i> < 0.001), ESS (<i>p</i> < 0.001), GAD-7 score (<i>p</i> < 0.0001), and [t90] (<i>p</i> < 0.0001), while GAD-7 was correlated with AHI (<i>p</i> < 0.030), ODI (<i>p</i> < 0.006), and [t90] (<i>p</i> < 0.001). The PHQ-9 and GAD-7 scores decreased significantly after 6 months of CPAP therapy in all groups and after 1 year of CPAP use. <i>Conclusions:</i> OSA patients should be screened for depression and anxiety. Furthermore, CPAP should be the first choice of treatment before starting other treatments for depression and anxiety symptoms.https://www.mdpi.com/1648-9144/58/10/1402depressionanxietyobstructive sleep apneacontinuous positive airway pressure |
| spellingShingle | Diana Raluca Velescu Monica Marc Diana Manolescu Daniel Trăilă Cristian Oancea CPAP Therapy on Depressive and Anxiety Symptoms in Patients with Moderate to Severe Obstructive Sleep Apnea Syndrome Medicina depression anxiety obstructive sleep apnea continuous positive airway pressure |
| title | CPAP Therapy on Depressive and Anxiety Symptoms in Patients with Moderate to Severe Obstructive Sleep Apnea Syndrome |
| title_full | CPAP Therapy on Depressive and Anxiety Symptoms in Patients with Moderate to Severe Obstructive Sleep Apnea Syndrome |
| title_fullStr | CPAP Therapy on Depressive and Anxiety Symptoms in Patients with Moderate to Severe Obstructive Sleep Apnea Syndrome |
| title_full_unstemmed | CPAP Therapy on Depressive and Anxiety Symptoms in Patients with Moderate to Severe Obstructive Sleep Apnea Syndrome |
| title_short | CPAP Therapy on Depressive and Anxiety Symptoms in Patients with Moderate to Severe Obstructive Sleep Apnea Syndrome |
| title_sort | cpap therapy on depressive and anxiety symptoms in patients with moderate to severe obstructive sleep apnea syndrome |
| topic | depression anxiety obstructive sleep apnea continuous positive airway pressure |
| url | https://www.mdpi.com/1648-9144/58/10/1402 |
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