Common herbal treatments for senile dementia in ancient civilizations: Greco-Roman, Chinese, Indian, and Iranian
Background: Senile dementia is the most common kind of dementia with considerable social and economic costs. Since the nature of disease is multi-pathological, current treatments cannot cover all aspects of the disease. Recently, scientific considerations have focused on the role of natural products...
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| Format: | Article |
| Language: | English |
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Institue of Medicinal Plants, ACECR
2020-03-01
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| Series: | Journal of Medicinal Plants |
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| Online Access: | http://jmp.ir/article-1-2328-en.html |
| _version_ | 1818439402433544192 |
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| author | Mohammad Mahdi Ahmadian-Attari Solat Eslami Leila Dargahi Ahmad Ali Noorbala |
| author_facet | Mohammad Mahdi Ahmadian-Attari Solat Eslami Leila Dargahi Ahmad Ali Noorbala |
| author_sort | Mohammad Mahdi Ahmadian-Attari |
| collection | DOAJ |
| description | Background: Senile dementia is the most common kind of dementia with considerable social and economic costs. Since the nature of disease is multi-pathological, current treatments cannot cover all aspects of the disease. Recently, scientific considerations have focused on the role of natural products, especially those with traditional backgrounds. Objective: to review natural treatments of dementia in ancient Greek, traditional Chinese, Ayurveda, and Iranian traditional medicines with concentration on common herbs concurrently mentioned in two or more than two of them. Methods: Scopus database and primary sources were thoroughly searched for selective keywords. The common herbs concurrently mentioned in two or more than two of the aforementioned traditional medicines were selected to deeply investigate for their active ingredients as well as their mechanisms of actions. Results: The results showed that Acorus calamus, Nardostachys jatamansi, Glycyrrhiza glabra, Phyllanthus emblica, Semencarpus anacardium, Terminalia chebula, and Zingiber officinale had been commonly prescribed for dementia in mentioned traditional systems. According to pharmacological studies, these herbs act their anti-dementia effects via cholinergic, anti-NMDA, antioxidant, anti-inflammatory, anti-apoptotic, and anti-β amyloid activities. Furthermore, 16 active principles of these herbs were identified, including α- and β-asarone, desoxo-narchinol A, narchinol B, glabridin, liquiritigenin, emblicanins A and B, 3, 5, 6, 3chr('39'), 5chr('39'), 6chr('39')-hexahydroxybiphenyl-2, 2chr('39')-dicarboxylic acid, 1chr('39'),2chr('39')-dihydroxy-3chr('39')-pentadec-8-enylbenzene, 1chr('39'),2chr('39')-dihydroxy-3chr('39')-pentadeca-8,11-dienylbenzene, chebulagic acid, and 1,2,3,4,6-penta-O-galloyl-β-d-glucose, Zingipain, 6-gingerol, and 6-shogaol. Conclusion: Chinese, Indian, and Iranian traditional medicine can play a complementary and alternative role in preventing and treating senile dementia. The scientific evidence supports their traditional anti-dementia claims. |
| first_indexed | 2024-12-14T17:55:54Z |
| format | Article |
| id | doaj.art-611e34f8b1ec491bac0b0ff224b4342c |
| institution | Directory Open Access Journal |
| issn | 2717-204X 2717-2058 |
| language | English |
| last_indexed | 2024-12-14T17:55:54Z |
| publishDate | 2020-03-01 |
| publisher | Institue of Medicinal Plants, ACECR |
| record_format | Article |
| series | Journal of Medicinal Plants |
| spelling | doaj.art-611e34f8b1ec491bac0b0ff224b4342c2022-12-21T22:52:32ZengInstitue of Medicinal Plants, ACECRJournal of Medicinal Plants2717-204X2717-20582020-03-0119733762Common herbal treatments for senile dementia in ancient civilizations: Greco-Roman, Chinese, Indian, and IranianMohammad Mahdi Ahmadian-Attari0Solat Eslami1Leila Dargahi2Ahmad Ali Noorbala3 Evidence-based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran Dietary Supplements & Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran NeuroBiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Psychosomatic Medicine Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran Background: Senile dementia is the most common kind of dementia with considerable social and economic costs. Since the nature of disease is multi-pathological, current treatments cannot cover all aspects of the disease. Recently, scientific considerations have focused on the role of natural products, especially those with traditional backgrounds. Objective: to review natural treatments of dementia in ancient Greek, traditional Chinese, Ayurveda, and Iranian traditional medicines with concentration on common herbs concurrently mentioned in two or more than two of them. Methods: Scopus database and primary sources were thoroughly searched for selective keywords. The common herbs concurrently mentioned in two or more than two of the aforementioned traditional medicines were selected to deeply investigate for their active ingredients as well as their mechanisms of actions. Results: The results showed that Acorus calamus, Nardostachys jatamansi, Glycyrrhiza glabra, Phyllanthus emblica, Semencarpus anacardium, Terminalia chebula, and Zingiber officinale had been commonly prescribed for dementia in mentioned traditional systems. According to pharmacological studies, these herbs act their anti-dementia effects via cholinergic, anti-NMDA, antioxidant, anti-inflammatory, anti-apoptotic, and anti-β amyloid activities. Furthermore, 16 active principles of these herbs were identified, including α- and β-asarone, desoxo-narchinol A, narchinol B, glabridin, liquiritigenin, emblicanins A and B, 3, 5, 6, 3chr('39'), 5chr('39'), 6chr('39')-hexahydroxybiphenyl-2, 2chr('39')-dicarboxylic acid, 1chr('39'),2chr('39')-dihydroxy-3chr('39')-pentadec-8-enylbenzene, 1chr('39'),2chr('39')-dihydroxy-3chr('39')-pentadeca-8,11-dienylbenzene, chebulagic acid, and 1,2,3,4,6-penta-O-galloyl-β-d-glucose, Zingipain, 6-gingerol, and 6-shogaol. Conclusion: Chinese, Indian, and Iranian traditional medicine can play a complementary and alternative role in preventing and treating senile dementia. The scientific evidence supports their traditional anti-dementia claims.http://jmp.ir/article-1-2328-en.htmlsenile dementiaalzheimer's diseasetraditional medicinenatural productsevidence-based phytotherapy |
| spellingShingle | Mohammad Mahdi Ahmadian-Attari Solat Eslami Leila Dargahi Ahmad Ali Noorbala Common herbal treatments for senile dementia in ancient civilizations: Greco-Roman, Chinese, Indian, and Iranian Journal of Medicinal Plants senile dementia alzheimer's disease traditional medicine natural products evidence-based phytotherapy |
| title | Common herbal treatments for senile dementia in ancient civilizations:
Greco-Roman, Chinese, Indian, and Iranian |
| title_full | Common herbal treatments for senile dementia in ancient civilizations:
Greco-Roman, Chinese, Indian, and Iranian |
| title_fullStr | Common herbal treatments for senile dementia in ancient civilizations:
Greco-Roman, Chinese, Indian, and Iranian |
| title_full_unstemmed | Common herbal treatments for senile dementia in ancient civilizations:
Greco-Roman, Chinese, Indian, and Iranian |
| title_short | Common herbal treatments for senile dementia in ancient civilizations:
Greco-Roman, Chinese, Indian, and Iranian |
| title_sort | common herbal treatments for senile dementia in ancient civilizations greco roman chinese indian and iranian |
| topic | senile dementia alzheimer's disease traditional medicine natural products evidence-based phytotherapy |
| url | http://jmp.ir/article-1-2328-en.html |
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