Group B <i>Streptococcus</i> Early-Onset Disease: New Preventive and Diagnostic Tools to Decrease the Burden of Antibiotic Use
The difficulty in recognizing early-onset neonatal sepsis (EONS) in a timely manner due to non-specific symptoms and the limitations of diagnostic tests, combined with the risk of serious consequences if EONS is not treated in a timely manner, has resulted in a low threshold for starting empirical a...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/3/489 |
| _version_ | 1797613851200454656 |
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| author | Charlotte M. Nusman Linde Snoek Lisanne M. van Leeuwen Thomas H. Dierikx Bo M. van der Weijden Niek B. Achten Merijn W. Bijlsma Douwe H. Visser Marlies A. van Houten Vincent Bekker Tim G. J. de Meij Ellen van Rossem Mariet Felderhof Frans B. Plötz |
| author_facet | Charlotte M. Nusman Linde Snoek Lisanne M. van Leeuwen Thomas H. Dierikx Bo M. van der Weijden Niek B. Achten Merijn W. Bijlsma Douwe H. Visser Marlies A. van Houten Vincent Bekker Tim G. J. de Meij Ellen van Rossem Mariet Felderhof Frans B. Plötz |
| author_sort | Charlotte M. Nusman |
| collection | DOAJ |
| description | The difficulty in recognizing early-onset neonatal sepsis (EONS) in a timely manner due to non-specific symptoms and the limitations of diagnostic tests, combined with the risk of serious consequences if EONS is not treated in a timely manner, has resulted in a low threshold for starting empirical antibiotic treatment. New guideline strategies, such as the neonatal sepsis calculator, have been proven to reduce the antibiotic burden related to EONS, but lack sensitivity for detecting EONS. In this review, the potential of novel, targeted preventive and diagnostic methods for EONS is discussed from three different perspectives: maternal, umbilical cord and newborn perspectives. Promising strategies from the maternal perspective include Group B <i>Streptococcus</i> (GBS) prevention, exploring the virulence factors of GBS, maternal immunization and antepartum biomarkers. The diagnostic methods obtained from the umbilical cord are preliminary but promising. Finally, promising fields from the newborn perspective include biomarkers, new microbiological techniques and clinical prediction and monitoring strategies. Consensus on the definition of EONS and the standardization of research on novel diagnostic biomarkers are crucial for future implementation and to reduce current antibiotic overexposure in newborns. |
| first_indexed | 2024-03-11T07:01:26Z |
| format | Article |
| id | doaj.art-612009c0d32f40ba983533868c95082e |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T07:01:26Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-612009c0d32f40ba983533868c95082e2023-11-17T09:13:43ZengMDPI AGAntibiotics2079-63822023-03-0112348910.3390/antibiotics12030489Group B <i>Streptococcus</i> Early-Onset Disease: New Preventive and Diagnostic Tools to Decrease the Burden of Antibiotic UseCharlotte M. Nusman0Linde Snoek1Lisanne M. van Leeuwen2Thomas H. Dierikx3Bo M. van der Weijden4Niek B. Achten5Merijn W. Bijlsma6Douwe H. Visser7Marlies A. van Houten8Vincent Bekker9Tim G. J. de Meij10Ellen van Rossem11Mariet Felderhof12Frans B. Plötz13Department of Paediatrics, Emma Children’s Hospital, Amsterdam University Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsDepartment of Neurology, Amsterdam University Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsDepartment of Paediatrics and Department of Vaccin, Infection and Immunology, Spaarne Hospital, Boerhaavelaan 22, 2035 RC Haarlem, The NetherlandsDepartment of Pediatric Gastroenterology, Emma Children’s Hospital, Amsterdam University Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsDepartment of Paediatrics, Emma Children’s Hospital, Amsterdam University Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsDepartment of Paediatrics, Erasmus University Medical Centre, Sophia Children’s Hospital, Wytemaweg 80, 3015 CN Rotterdam, The NetherlandsDepartment of Paediatrics, Emma Children’s Hospital, Amsterdam University Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsDepartment of Neonatology, Emma Children’s Hospital, Amsterdam University Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsDepartment of Paediatrics and Department of Vaccin, Infection and Immunology, Spaarne Hospital, Boerhaavelaan 22, 2035 RC Haarlem, The NetherlandsDivision of Neonatology, Department of Pediatrics, Willem Alexander Children’s Hospital, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The NetherlandsDepartment of Pediatric Gastroenterology, Emma Children’s Hospital, Amsterdam University Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsDepartment of Paediatrics, Flevo Hospital, Hospitaalweg 1, 1315 RA Almere, The NetherlandsDepartment of Paediatrics, Flevo Hospital, Hospitaalweg 1, 1315 RA Almere, The NetherlandsDepartment of Paediatrics, Emma Children’s Hospital, Amsterdam University Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsThe difficulty in recognizing early-onset neonatal sepsis (EONS) in a timely manner due to non-specific symptoms and the limitations of diagnostic tests, combined with the risk of serious consequences if EONS is not treated in a timely manner, has resulted in a low threshold for starting empirical antibiotic treatment. New guideline strategies, such as the neonatal sepsis calculator, have been proven to reduce the antibiotic burden related to EONS, but lack sensitivity for detecting EONS. In this review, the potential of novel, targeted preventive and diagnostic methods for EONS is discussed from three different perspectives: maternal, umbilical cord and newborn perspectives. Promising strategies from the maternal perspective include Group B <i>Streptococcus</i> (GBS) prevention, exploring the virulence factors of GBS, maternal immunization and antepartum biomarkers. The diagnostic methods obtained from the umbilical cord are preliminary but promising. Finally, promising fields from the newborn perspective include biomarkers, new microbiological techniques and clinical prediction and monitoring strategies. Consensus on the definition of EONS and the standardization of research on novel diagnostic biomarkers are crucial for future implementation and to reduce current antibiotic overexposure in newborns.https://www.mdpi.com/2079-6382/12/3/489antibioticsbiomarkersblood cultureearly-onset neonatal sepsisGroup B <i>Streptococcus</i>guidelines |
| spellingShingle | Charlotte M. Nusman Linde Snoek Lisanne M. van Leeuwen Thomas H. Dierikx Bo M. van der Weijden Niek B. Achten Merijn W. Bijlsma Douwe H. Visser Marlies A. van Houten Vincent Bekker Tim G. J. de Meij Ellen van Rossem Mariet Felderhof Frans B. Plötz Group B <i>Streptococcus</i> Early-Onset Disease: New Preventive and Diagnostic Tools to Decrease the Burden of Antibiotic Use Antibiotics antibiotics biomarkers blood culture early-onset neonatal sepsis Group B <i>Streptococcus</i> guidelines |
| title | Group B <i>Streptococcus</i> Early-Onset Disease: New Preventive and Diagnostic Tools to Decrease the Burden of Antibiotic Use |
| title_full | Group B <i>Streptococcus</i> Early-Onset Disease: New Preventive and Diagnostic Tools to Decrease the Burden of Antibiotic Use |
| title_fullStr | Group B <i>Streptococcus</i> Early-Onset Disease: New Preventive and Diagnostic Tools to Decrease the Burden of Antibiotic Use |
| title_full_unstemmed | Group B <i>Streptococcus</i> Early-Onset Disease: New Preventive and Diagnostic Tools to Decrease the Burden of Antibiotic Use |
| title_short | Group B <i>Streptococcus</i> Early-Onset Disease: New Preventive and Diagnostic Tools to Decrease the Burden of Antibiotic Use |
| title_sort | group b i streptococcus i early onset disease new preventive and diagnostic tools to decrease the burden of antibiotic use |
| topic | antibiotics biomarkers blood culture early-onset neonatal sepsis Group B <i>Streptococcus</i> guidelines |
| url | https://www.mdpi.com/2079-6382/12/3/489 |
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