Smaller Mean LDL Particle Size and Higher Proportion of Small Dense LDL in Korean Type 2 Diabetic Patients
BackgroundSmall dense low density lipoprotein (sdLDL) has recently emerged as an important risk factor of coronary heart disease.MethodsThe mean LDL particle size was measured in 203 patients with type 2 diabetes mellitus (T2DM) and 212 matched subjects without diabetes using polyacrylamide tube gel...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Diabetes Association
2011-10-01
|
| Series: | Diabetes & Metabolism Journal |
| Subjects: | |
| Online Access: | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-35-536.pdf |
| _version_ | 1818550496916406272 |
|---|---|
| author | Sunghwan Suh Hyung-Doo Park Se Won Kim Ji Cheol Bae Alice Hyun-Kyung Tan Hye Soo Chung Kyu Yeon Hur Jae Hyeon Kim Kwang-Won Kim Moon-Kyu Lee |
| author_facet | Sunghwan Suh Hyung-Doo Park Se Won Kim Ji Cheol Bae Alice Hyun-Kyung Tan Hye Soo Chung Kyu Yeon Hur Jae Hyeon Kim Kwang-Won Kim Moon-Kyu Lee |
| author_sort | Sunghwan Suh |
| collection | DOAJ |
| description | BackgroundSmall dense low density lipoprotein (sdLDL) has recently emerged as an important risk factor of coronary heart disease.MethodsThe mean LDL particle size was measured in 203 patients with type 2 diabetes mellitus (T2DM) and 212 matched subjects without diabetes using polyacrylamide tube gel electrophoresis. Major vascular complications were defined as stroke, angiographically-documented coronary artery disease or a myocardial infarction. Peripheral vascular stenosis, carotid artery stenosis (≥50% in diameter) or carotid artery plaque were considered minor vascular complications. Overall vascular complications included both major and minor vascular complications.ResultsDiabetic patients had significantly smaller mean-LDL particle size (26.32 nm vs. 26.49 nm) and a higher percentage of sdLDL to total LDL compared to those of subjects without diabetes (21.39% vs. 6.34%). The independent predictors of sdLDL in this study were serum triglyceride level and body mass index (odds ratio [OR], 1.020 with P<0.001 and OR 1.152 with P<0.027, respectively). However, no significant correlations were found between sdLDL and major vascular complications (P=0.342), minor vascular complications (P=0.573) or overall vascular complications (P=0.262) in diabetic subjects.ConclusionDiabetic patients had a smaller mean-LDL particle size and higher proportion of sdLDL compared to those of subjects without diabetes. Obese diabetic patients with hypertriglyceridemia have an increased risk for atherogenic small dense LDL. However, we could not verify an association between LDL particle size and vascular complications in this study. |
| first_indexed | 2024-12-12T08:47:15Z |
| format | Article |
| id | doaj.art-6120bc808c8c4c2b9334ff67d614c87d |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-12-12T08:47:15Z |
| publishDate | 2011-10-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-6120bc808c8c4c2b9334ff67d614c87d2022-12-22T00:30:28ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872011-10-0135553654210.4093/dmj.2011.35.5.5362644Smaller Mean LDL Particle Size and Higher Proportion of Small Dense LDL in Korean Type 2 Diabetic PatientsSunghwan SuhHyung-Doo ParkSe Won KimJi Cheol BaeAlice Hyun-Kyung TanHye Soo ChungKyu Yeon HurJae Hyeon KimKwang-Won KimMoon-Kyu LeeBackgroundSmall dense low density lipoprotein (sdLDL) has recently emerged as an important risk factor of coronary heart disease.MethodsThe mean LDL particle size was measured in 203 patients with type 2 diabetes mellitus (T2DM) and 212 matched subjects without diabetes using polyacrylamide tube gel electrophoresis. Major vascular complications were defined as stroke, angiographically-documented coronary artery disease or a myocardial infarction. Peripheral vascular stenosis, carotid artery stenosis (≥50% in diameter) or carotid artery plaque were considered minor vascular complications. Overall vascular complications included both major and minor vascular complications.ResultsDiabetic patients had significantly smaller mean-LDL particle size (26.32 nm vs. 26.49 nm) and a higher percentage of sdLDL to total LDL compared to those of subjects without diabetes (21.39% vs. 6.34%). The independent predictors of sdLDL in this study were serum triglyceride level and body mass index (odds ratio [OR], 1.020 with P<0.001 and OR 1.152 with P<0.027, respectively). However, no significant correlations were found between sdLDL and major vascular complications (P=0.342), minor vascular complications (P=0.573) or overall vascular complications (P=0.262) in diabetic subjects.ConclusionDiabetic patients had a smaller mean-LDL particle size and higher proportion of sdLDL compared to those of subjects without diabetes. Obese diabetic patients with hypertriglyceridemia have an increased risk for atherogenic small dense LDL. However, we could not verify an association between LDL particle size and vascular complications in this study.http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-35-536.pdfCoronary heart diseasesDiabetes mellitusLDL particle sizeSmall dense low density lipoprotein |
| spellingShingle | Sunghwan Suh Hyung-Doo Park Se Won Kim Ji Cheol Bae Alice Hyun-Kyung Tan Hye Soo Chung Kyu Yeon Hur Jae Hyeon Kim Kwang-Won Kim Moon-Kyu Lee Smaller Mean LDL Particle Size and Higher Proportion of Small Dense LDL in Korean Type 2 Diabetic Patients Diabetes & Metabolism Journal Coronary heart diseases Diabetes mellitus LDL particle size Small dense low density lipoprotein |
| title | Smaller Mean LDL Particle Size and Higher Proportion of Small Dense LDL in Korean Type 2 Diabetic Patients |
| title_full | Smaller Mean LDL Particle Size and Higher Proportion of Small Dense LDL in Korean Type 2 Diabetic Patients |
| title_fullStr | Smaller Mean LDL Particle Size and Higher Proportion of Small Dense LDL in Korean Type 2 Diabetic Patients |
| title_full_unstemmed | Smaller Mean LDL Particle Size and Higher Proportion of Small Dense LDL in Korean Type 2 Diabetic Patients |
| title_short | Smaller Mean LDL Particle Size and Higher Proportion of Small Dense LDL in Korean Type 2 Diabetic Patients |
| title_sort | smaller mean ldl particle size and higher proportion of small dense ldl in korean type 2 diabetic patients |
| topic | Coronary heart diseases Diabetes mellitus LDL particle size Small dense low density lipoprotein |
| url | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-35-536.pdf |
| work_keys_str_mv | AT sunghwansuh smallermeanldlparticlesizeandhigherproportionofsmalldenseldlinkoreantype2diabeticpatients AT hyungdoopark smallermeanldlparticlesizeandhigherproportionofsmalldenseldlinkoreantype2diabeticpatients AT sewonkim smallermeanldlparticlesizeandhigherproportionofsmalldenseldlinkoreantype2diabeticpatients AT jicheolbae smallermeanldlparticlesizeandhigherproportionofsmalldenseldlinkoreantype2diabeticpatients AT alicehyunkyungtan smallermeanldlparticlesizeandhigherproportionofsmalldenseldlinkoreantype2diabeticpatients AT hyesoochung smallermeanldlparticlesizeandhigherproportionofsmalldenseldlinkoreantype2diabeticpatients AT kyuyeonhur smallermeanldlparticlesizeandhigherproportionofsmalldenseldlinkoreantype2diabeticpatients AT jaehyeonkim smallermeanldlparticlesizeandhigherproportionofsmalldenseldlinkoreantype2diabeticpatients AT kwangwonkim smallermeanldlparticlesizeandhigherproportionofsmalldenseldlinkoreantype2diabeticpatients AT moonkyulee smallermeanldlparticlesizeandhigherproportionofsmalldenseldlinkoreantype2diabeticpatients |