Safety evaluation studies of Citrullus colocynthis for diabetes in rats
An experiment conducted in the department of Pharmacology and Toxicology, Nagpur Veterinary College, Nagpur reported Citrullus colocynthis to posses antidiabetic effect in rats at the rate of 50 mg/kg b.w and 100mg/kg b.w. So it was decided to also evaluate the safety of Citrullus colocynthis in rat...
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| Format: | Article |
| Language: | English |
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Veterinary World
2009-01-01
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| Series: | Veterinary World |
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| Online Access: | http://www.scopemed.org/fulltextpdf.php?mno=36530 |
| _version_ | 1819144882805014528 |
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| author | S.K Atole C.R Jangde Preety Philip D.S Rekhe D.V. Aghav H.J. Waghode A.M.Chougule |
| author_facet | S.K Atole C.R Jangde Preety Philip D.S Rekhe D.V. Aghav H.J. Waghode A.M.Chougule |
| author_sort | S.K Atole |
| collection | DOAJ |
| description | An experiment conducted in the department of Pharmacology and Toxicology, Nagpur Veterinary College, Nagpur reported Citrullus colocynthis to posses antidiabetic effect in rats at the rate of 50 mg/kg b.w and 100mg/kg b.w. So it was decided to also evaluate the safety of Citrullus colocynthis in rats at its antidiabetic dose. The experiment was conducted for 28 days .18 wistar rats were divided into three groups containing six rats in each group. Group T1 was maintained as normal control, whereas groups T2 and T3 received aqueous extract of Citrullus colocynthis @ 50 and 100 mg/kg body weight. Haematological and Biochemical estimations were done at the end of experiment i.e. on 29th day by using standard kits. Rats were then sacrificed and histopathological examinations were done. The results obtained showed that Citrullus colocynthis is safe at its antidiabetic dose and is safe for use as an antidiabetic remedy. [Vet World 2009; 2(11.000): 423-425] |
| first_indexed | 2024-12-22T12:49:12Z |
| format | Article |
| id | doaj.art-612174eee3cd4242a2ca77a981eabd94 |
| institution | Directory Open Access Journal |
| issn | 0972-8988 2231-0916 |
| language | English |
| last_indexed | 2024-12-22T12:49:12Z |
| publishDate | 2009-01-01 |
| publisher | Veterinary World |
| record_format | Article |
| series | Veterinary World |
| spelling | doaj.art-612174eee3cd4242a2ca77a981eabd942022-12-21T18:25:15ZengVeterinary WorldVeterinary World0972-89882231-09162009-01-01211.000423425Safety evaluation studies of Citrullus colocynthis for diabetes in ratsS.K AtoleC.R JangdePreety PhilipD.S RekheD.V. AghavH.J. WaghodeA.M.ChouguleAn experiment conducted in the department of Pharmacology and Toxicology, Nagpur Veterinary College, Nagpur reported Citrullus colocynthis to posses antidiabetic effect in rats at the rate of 50 mg/kg b.w and 100mg/kg b.w. So it was decided to also evaluate the safety of Citrullus colocynthis in rats at its antidiabetic dose. The experiment was conducted for 28 days .18 wistar rats were divided into three groups containing six rats in each group. Group T1 was maintained as normal control, whereas groups T2 and T3 received aqueous extract of Citrullus colocynthis @ 50 and 100 mg/kg body weight. Haematological and Biochemical estimations were done at the end of experiment i.e. on 29th day by using standard kits. Rats were then sacrificed and histopathological examinations were done. The results obtained showed that Citrullus colocynthis is safe at its antidiabetic dose and is safe for use as an antidiabetic remedy. [Vet World 2009; 2(11.000): 423-425]http://www.scopemed.org/fulltextpdf.php?mno=36530DiabetesSafety EvaluationMetabolic diseaseHerbal drug |
| spellingShingle | S.K Atole C.R Jangde Preety Philip D.S Rekhe D.V. Aghav H.J. Waghode A.M.Chougule Safety evaluation studies of Citrullus colocynthis for diabetes in rats Veterinary World Diabetes Safety Evaluation Metabolic disease Herbal drug |
| title | Safety evaluation studies of Citrullus colocynthis for diabetes in rats |
| title_full | Safety evaluation studies of Citrullus colocynthis for diabetes in rats |
| title_fullStr | Safety evaluation studies of Citrullus colocynthis for diabetes in rats |
| title_full_unstemmed | Safety evaluation studies of Citrullus colocynthis for diabetes in rats |
| title_short | Safety evaluation studies of Citrullus colocynthis for diabetes in rats |
| title_sort | safety evaluation studies of citrullus colocynthis for diabetes in rats |
| topic | Diabetes Safety Evaluation Metabolic disease Herbal drug |
| url | http://www.scopemed.org/fulltextpdf.php?mno=36530 |
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