Epidemiology of Preventable Drug-Related Problems (DRPs) Among Hospitalized Children at KAMC-Jeddah: a Single-Institution Observation Study
Aeshah AlAzmi,1,2 Omaima Ahmed,2 Hani Alhamdan,1 Hanan AlGarni,3 Rawan Mohammed Elzain,3 Rihad S AlThubaiti,3 Mohammed Aseeri,1 Adnan Al Shaikh4 1Ministry of National Guard Health Affairs (MNGHA), King Abdulaziz Medical City (KAMC), Pharmaceutical Care Services Department, Clinical Pharmacy Section,...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2019-11-01
|
| Series: | Drug, Healthcare and Patient Safety |
| Subjects: | |
| Online Access: | https://www.dovepress.com/epidemiology-of-preventable-drug-related-problems-drps-among-hospitali-peer-reviewed-article-DHPS |
| _version_ | 1818459332725964800 |
|---|---|
| author | AlAzmi A Ahmed O Alhamdan H AlGarni H Elzain RM AlThubaiti RS Aseeri M Al Shaikh A |
| author_facet | AlAzmi A Ahmed O Alhamdan H AlGarni H Elzain RM AlThubaiti RS Aseeri M Al Shaikh A |
| author_sort | AlAzmi A |
| collection | DOAJ |
| description | Aeshah AlAzmi,1,2 Omaima Ahmed,2 Hani Alhamdan,1 Hanan AlGarni,3 Rawan Mohammed Elzain,3 Rihad S AlThubaiti,3 Mohammed Aseeri,1 Adnan Al Shaikh4 1Ministry of National Guard Health Affairs (MNGHA), King Abdulaziz Medical City (KAMC), Pharmaceutical Care Services Department, Clinical Pharmacy Section, Jeddah, Saudi Arabia; 2Princes Noorah Oncology Center (PNOC), Pediatric Oncology/Hematology/BMT Section, King Abdulaziz Medical City (KAMC), Jeddah, Saudi Arabia; 3Ibn Sina National College for Medical Studies, Pharmacy College, Jeddah, Saudi Arabia; 4Ministry of National Guard Health Affairs (MNGHA), King Abdulaziz Medical City (KAMC), King Saud bin Abdulaziz University for Health Sciences, Department of Pediatrics, Chemistry Laboratory, Community Medicine, Jeddah, Saudi ArabiaCorrespondence: Aeshah AlAzmiKAMC 6255, Jeddah, 21423, Saudi ArabiaTel +966 122266666 Ext 22861Email Aeshah.alazmi@gmail.comAim: Drug-related problems (DRPs) “are the unwanted effects of drugs that potentially lead to a harmful outcome” thereby requiring considerable attention. Hospitalized pediatric patients, in particular, represent a population at risk of DRPs. The epidemiology of preventable DRPs among children in Saudi Arabia remains scarce, which thus poses distinct challenges to all healthcare professionals. We aim to characterize preventable DRPs among hospitalized children at KAMC-Jeddah.Methods: A prospective observational study of children (≤15 years) admitted to pediatric units (excluding cancer units) at KAMC-Jeddah over a 3-month period (May 29 to August 30, 2016) is carried out to determine the incidence of preventable DRPs and investigate the possible associated factors (gender, age, admission location, type of admission, and number of medications).Results: A total of 319 DRPs were identified among 235 patients, of which 280 DRPs (87.8%, 280/319) were deemed preventable. The majority of preventable DRPs were related to dose selection (78%, 219/280). None of the preventable DRPs were life threatening or fatal, and the majority were assessed as moderate in severity (94.3%, 264/280). There was no significant difference between DRP incidences with age mean 3.5 (P=0.389), gender mean (P=0.436), and weight mean 13.47 (P=0.323). Younger children (age ≤2years) admitted to PICU were more likely to have DRP (OR 4.44, 95% CI, 1.87 to 10.52, P=0.00001). Scheduled admissions were 2.89 times more likely to be exposed to DRP compared to transferred admissions (OR 2.8, 95% CI, 1.83 to 4.70, P=0.005). Additionally, DRP incidences increased proportionally to the number of medications.Conclusion: Our data suggest that establishing appropriate prevention strategies towards improvement and safety in medicine use among this vulnerable patient population is a high priority.Keywords: children, risk factors, drug-related problems, hospitalized pediatric patients |
| first_indexed | 2024-12-14T23:12:41Z |
| format | Article |
| id | doaj.art-6121e38003f34e6caca9dd548f350dd0 |
| institution | Directory Open Access Journal |
| issn | 1179-1365 |
| language | English |
| last_indexed | 2024-12-14T23:12:41Z |
| publishDate | 2019-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug, Healthcare and Patient Safety |
| spelling | doaj.art-6121e38003f34e6caca9dd548f350dd02022-12-21T22:44:10ZengDove Medical PressDrug, Healthcare and Patient Safety1179-13652019-11-01Volume 119510350060Epidemiology of Preventable Drug-Related Problems (DRPs) Among Hospitalized Children at KAMC-Jeddah: a Single-Institution Observation StudyAlAzmi AAhmed OAlhamdan HAlGarni HElzain RMAlThubaiti RSAseeri MAl Shaikh AAeshah AlAzmi,1,2 Omaima Ahmed,2 Hani Alhamdan,1 Hanan AlGarni,3 Rawan Mohammed Elzain,3 Rihad S AlThubaiti,3 Mohammed Aseeri,1 Adnan Al Shaikh4 1Ministry of National Guard Health Affairs (MNGHA), King Abdulaziz Medical City (KAMC), Pharmaceutical Care Services Department, Clinical Pharmacy Section, Jeddah, Saudi Arabia; 2Princes Noorah Oncology Center (PNOC), Pediatric Oncology/Hematology/BMT Section, King Abdulaziz Medical City (KAMC), Jeddah, Saudi Arabia; 3Ibn Sina National College for Medical Studies, Pharmacy College, Jeddah, Saudi Arabia; 4Ministry of National Guard Health Affairs (MNGHA), King Abdulaziz Medical City (KAMC), King Saud bin Abdulaziz University for Health Sciences, Department of Pediatrics, Chemistry Laboratory, Community Medicine, Jeddah, Saudi ArabiaCorrespondence: Aeshah AlAzmiKAMC 6255, Jeddah, 21423, Saudi ArabiaTel +966 122266666 Ext 22861Email Aeshah.alazmi@gmail.comAim: Drug-related problems (DRPs) “are the unwanted effects of drugs that potentially lead to a harmful outcome” thereby requiring considerable attention. Hospitalized pediatric patients, in particular, represent a population at risk of DRPs. The epidemiology of preventable DRPs among children in Saudi Arabia remains scarce, which thus poses distinct challenges to all healthcare professionals. We aim to characterize preventable DRPs among hospitalized children at KAMC-Jeddah.Methods: A prospective observational study of children (≤15 years) admitted to pediatric units (excluding cancer units) at KAMC-Jeddah over a 3-month period (May 29 to August 30, 2016) is carried out to determine the incidence of preventable DRPs and investigate the possible associated factors (gender, age, admission location, type of admission, and number of medications).Results: A total of 319 DRPs were identified among 235 patients, of which 280 DRPs (87.8%, 280/319) were deemed preventable. The majority of preventable DRPs were related to dose selection (78%, 219/280). None of the preventable DRPs were life threatening or fatal, and the majority were assessed as moderate in severity (94.3%, 264/280). There was no significant difference between DRP incidences with age mean 3.5 (P=0.389), gender mean (P=0.436), and weight mean 13.47 (P=0.323). Younger children (age ≤2years) admitted to PICU were more likely to have DRP (OR 4.44, 95% CI, 1.87 to 10.52, P=0.00001). Scheduled admissions were 2.89 times more likely to be exposed to DRP compared to transferred admissions (OR 2.8, 95% CI, 1.83 to 4.70, P=0.005). Additionally, DRP incidences increased proportionally to the number of medications.Conclusion: Our data suggest that establishing appropriate prevention strategies towards improvement and safety in medicine use among this vulnerable patient population is a high priority.Keywords: children, risk factors, drug-related problems, hospitalized pediatric patientshttps://www.dovepress.com/epidemiology-of-preventable-drug-related-problems-drps-among-hospitali-peer-reviewed-article-DHPSchildrenrisk factorsdrug-related problemshospitalized pediatric patients. |
| spellingShingle | AlAzmi A Ahmed O Alhamdan H AlGarni H Elzain RM AlThubaiti RS Aseeri M Al Shaikh A Epidemiology of Preventable Drug-Related Problems (DRPs) Among Hospitalized Children at KAMC-Jeddah: a Single-Institution Observation Study Drug, Healthcare and Patient Safety children risk factors drug-related problems hospitalized pediatric patients. |
| title | Epidemiology of Preventable Drug-Related Problems (DRPs) Among Hospitalized Children at KAMC-Jeddah: a Single-Institution Observation Study |
| title_full | Epidemiology of Preventable Drug-Related Problems (DRPs) Among Hospitalized Children at KAMC-Jeddah: a Single-Institution Observation Study |
| title_fullStr | Epidemiology of Preventable Drug-Related Problems (DRPs) Among Hospitalized Children at KAMC-Jeddah: a Single-Institution Observation Study |
| title_full_unstemmed | Epidemiology of Preventable Drug-Related Problems (DRPs) Among Hospitalized Children at KAMC-Jeddah: a Single-Institution Observation Study |
| title_short | Epidemiology of Preventable Drug-Related Problems (DRPs) Among Hospitalized Children at KAMC-Jeddah: a Single-Institution Observation Study |
| title_sort | epidemiology of preventable drug related problems drps among hospitalized children at kamc jeddah a single institution observation study |
| topic | children risk factors drug-related problems hospitalized pediatric patients. |
| url | https://www.dovepress.com/epidemiology-of-preventable-drug-related-problems-drps-among-hospitali-peer-reviewed-article-DHPS |
| work_keys_str_mv | AT alazmia epidemiologyofpreventabledrugrelatedproblemsdrpsamonghospitalizedchildrenatkamcjeddahasingleinstitutionobservationstudy AT ahmedo epidemiologyofpreventabledrugrelatedproblemsdrpsamonghospitalizedchildrenatkamcjeddahasingleinstitutionobservationstudy AT alhamdanh epidemiologyofpreventabledrugrelatedproblemsdrpsamonghospitalizedchildrenatkamcjeddahasingleinstitutionobservationstudy AT algarnih epidemiologyofpreventabledrugrelatedproblemsdrpsamonghospitalizedchildrenatkamcjeddahasingleinstitutionobservationstudy AT elzainrm epidemiologyofpreventabledrugrelatedproblemsdrpsamonghospitalizedchildrenatkamcjeddahasingleinstitutionobservationstudy AT althubaitirs epidemiologyofpreventabledrugrelatedproblemsdrpsamonghospitalizedchildrenatkamcjeddahasingleinstitutionobservationstudy AT aseerim epidemiologyofpreventabledrugrelatedproblemsdrpsamonghospitalizedchildrenatkamcjeddahasingleinstitutionobservationstudy AT alshaikha epidemiologyofpreventabledrugrelatedproblemsdrpsamonghospitalizedchildrenatkamcjeddahasingleinstitutionobservationstudy |