Cultured Human Foreskin as a Model System for Evaluating Ionizing Radiation-Induced Skin Injury

Cultured Human Foreskin as a Model System for Evaluating Ionizing Radiation-Induced Skin Injury

Purpose: Precise molecular and cellular mechanisms of radiation-induced dermatitis are incompletely understood. Histone variant H2A.J is associated with cellular senescence and modulates senescence-associated secretory phenotype (SASP) after DNA-damaging insults, such as ionizing radiation (IR). Usi...

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Bibliographic Details
Main Authors: Yanick Hippchen, Gargi Tewary, Daniela Jung, Zoé Schmal, Stephan Meessen, Jan Palm, Claudia E. Rübe
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
cultured foreskin
ionizing radiation
radiation-induced dermatitis
histone variant H2A.J
cellular senescence
senescence-associated secretory phenotype (SASP)
Online Access:https://www.mdpi.com/1422-0067/23/17/9830

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