Neuroinflammation: The central enabler of postoperative cognitive dysfunction
The proportion of advanced age patients undergoing surgical procedures is on the rise owing to advancements in surgical and anesthesia technologies as well as an overall aging population. As a complication of anesthesia and surgery, older patients frequently suffer from postoperative cognitive dysfu...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S075333222301380X |
| _version_ | 1797660508557410304 |
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| author | Yang Liu Wei Yang Jinqi Xue Juntong Chen Shiqing Liu Shijie Zhang Xiaohui Zhang Xi Gu Youjing Dong Peng Qiu |
| author_facet | Yang Liu Wei Yang Jinqi Xue Juntong Chen Shiqing Liu Shijie Zhang Xiaohui Zhang Xi Gu Youjing Dong Peng Qiu |
| author_sort | Yang Liu |
| collection | DOAJ |
| description | The proportion of advanced age patients undergoing surgical procedures is on the rise owing to advancements in surgical and anesthesia technologies as well as an overall aging population. As a complication of anesthesia and surgery, older patients frequently suffer from postoperative cognitive dysfunction (POCD), which may persist for weeks, months or even longer. POCD is a complex pathological process involving multiple pathogenic factors, and its mechanism is yet unclear. Potential theories include inflammation, deposition of pathogenic proteins, imbalance of neurotransmitters, and chronic stress. The identification, prevention, and treatment of POCD are still in the exploratory stages owing to the absence of standardized diagnostic criteria. Undoubtedly, comprehending the development of POCD remains crucial in overcoming the illness. Neuroinflammation is the leading hypothesis and a crucial component of the pathological network of POCD and may have complex interactions with other mechanisms. In this review, we discuss the possible ways in which surgery and anesthesia cause neuroinflammation and investigate the connection between neuroinflammation and the development of POCD. Understanding these mechanisms may likely ensure that future treatment options of POCD are more effective. |
| first_indexed | 2024-03-11T18:31:54Z |
| format | Article |
| id | doaj.art-612360bec89d4090b81d077a8454228e |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-11T18:31:54Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-612360bec89d4090b81d077a8454228e2023-10-13T11:03:13ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-11-01167115582Neuroinflammation: The central enabler of postoperative cognitive dysfunctionYang Liu0Wei Yang1Jinqi Xue2Juntong Chen3Shiqing Liu4Shijie Zhang5Xiaohui Zhang6Xi Gu7Youjing Dong8Peng Qiu9Department of Oncology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning province, ChinaDepartment of Infectious Disease, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning province, ChinaDepartment of Oncology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning province, ChinaZhejiang University School of Medicine, Hangzhou 311121, Zhejiang province, ChinaDepartment of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, ChinaDepartment of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, ChinaDepartment of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, ChinaDepartment of Oncology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning province, China; Corresponding authors.Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China; Corresponding authors.Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China; Corresponding authors.The proportion of advanced age patients undergoing surgical procedures is on the rise owing to advancements in surgical and anesthesia technologies as well as an overall aging population. As a complication of anesthesia and surgery, older patients frequently suffer from postoperative cognitive dysfunction (POCD), which may persist for weeks, months or even longer. POCD is a complex pathological process involving multiple pathogenic factors, and its mechanism is yet unclear. Potential theories include inflammation, deposition of pathogenic proteins, imbalance of neurotransmitters, and chronic stress. The identification, prevention, and treatment of POCD are still in the exploratory stages owing to the absence of standardized diagnostic criteria. Undoubtedly, comprehending the development of POCD remains crucial in overcoming the illness. Neuroinflammation is the leading hypothesis and a crucial component of the pathological network of POCD and may have complex interactions with other mechanisms. In this review, we discuss the possible ways in which surgery and anesthesia cause neuroinflammation and investigate the connection between neuroinflammation and the development of POCD. Understanding these mechanisms may likely ensure that future treatment options of POCD are more effective.http://www.sciencedirect.com/science/article/pii/S075333222301380XPostoperative cognitive dysfunctionInflammationNeuroinflammationMicrogliaAstrocyte |
| spellingShingle | Yang Liu Wei Yang Jinqi Xue Juntong Chen Shiqing Liu Shijie Zhang Xiaohui Zhang Xi Gu Youjing Dong Peng Qiu Neuroinflammation: The central enabler of postoperative cognitive dysfunction Biomedicine & Pharmacotherapy Postoperative cognitive dysfunction Inflammation Neuroinflammation Microglia Astrocyte |
| title | Neuroinflammation: The central enabler of postoperative cognitive dysfunction |
| title_full | Neuroinflammation: The central enabler of postoperative cognitive dysfunction |
| title_fullStr | Neuroinflammation: The central enabler of postoperative cognitive dysfunction |
| title_full_unstemmed | Neuroinflammation: The central enabler of postoperative cognitive dysfunction |
| title_short | Neuroinflammation: The central enabler of postoperative cognitive dysfunction |
| title_sort | neuroinflammation the central enabler of postoperative cognitive dysfunction |
| topic | Postoperative cognitive dysfunction Inflammation Neuroinflammation Microglia Astrocyte |
| url | http://www.sciencedirect.com/science/article/pii/S075333222301380X |
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