Response to Preoperative Therapy in Localized Pancreatic Cancer
Evaluation of response to preoperative therapy for patients with pancreatic adenocarcinoma has been historically difficult. Therefore, preoperative regimens have generally been selected on the basis of baseline data such as radiographic stage and serum CA 19-9 level and then typically administered f...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.00516/full |
| _version_ | 1818310546812829696 |
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| author | Giampaolo Perri Laura R. Prakash Matthew H. G. Katz |
| author_facet | Giampaolo Perri Laura R. Prakash Matthew H. G. Katz |
| author_sort | Giampaolo Perri |
| collection | DOAJ |
| description | Evaluation of response to preoperative therapy for patients with pancreatic adenocarcinoma has been historically difficult. Therefore, preoperative regimens have generally been selected on the basis of baseline data such as radiographic stage and serum CA 19-9 level and then typically administered for a pre-specified duration as long as 6 months or more. The decision to proceed with resection following preoperative therapy likewise has rested upon the absence of disease progression rather than evidence for tumor response. This article reviews the basis for the evaluation of therapeutic response after preoperative therapy for pancreatic cancer in the existing scientific literature, and providing updates and new perspectives. |
| first_indexed | 2024-12-13T07:47:47Z |
| format | Article |
| id | doaj.art-61239c09c3234c1bbff98fce69b2ae69 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-13T07:47:47Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-61239c09c3234c1bbff98fce69b2ae692022-12-21T23:54:47ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-04-011010.3389/fonc.2020.00516496882Response to Preoperative Therapy in Localized Pancreatic CancerGiampaolo PerriLaura R. PrakashMatthew H. G. KatzEvaluation of response to preoperative therapy for patients with pancreatic adenocarcinoma has been historically difficult. Therefore, preoperative regimens have generally been selected on the basis of baseline data such as radiographic stage and serum CA 19-9 level and then typically administered for a pre-specified duration as long as 6 months or more. The decision to proceed with resection following preoperative therapy likewise has rested upon the absence of disease progression rather than evidence for tumor response. This article reviews the basis for the evaluation of therapeutic response after preoperative therapy for pancreatic cancer in the existing scientific literature, and providing updates and new perspectives.https://www.frontiersin.org/article/10.3389/fonc.2020.00516/fullpancreatic cancerpreoperative therapytumor responsepathologic responseradiographic response |
| spellingShingle | Giampaolo Perri Laura R. Prakash Matthew H. G. Katz Response to Preoperative Therapy in Localized Pancreatic Cancer Frontiers in Oncology pancreatic cancer preoperative therapy tumor response pathologic response radiographic response |
| title | Response to Preoperative Therapy in Localized Pancreatic Cancer |
| title_full | Response to Preoperative Therapy in Localized Pancreatic Cancer |
| title_fullStr | Response to Preoperative Therapy in Localized Pancreatic Cancer |
| title_full_unstemmed | Response to Preoperative Therapy in Localized Pancreatic Cancer |
| title_short | Response to Preoperative Therapy in Localized Pancreatic Cancer |
| title_sort | response to preoperative therapy in localized pancreatic cancer |
| topic | pancreatic cancer preoperative therapy tumor response pathologic response radiographic response |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.00516/full |
| work_keys_str_mv | AT giampaoloperri responsetopreoperativetherapyinlocalizedpancreaticcancer AT laurarprakash responsetopreoperativetherapyinlocalizedpancreaticcancer AT matthewhgkatz responsetopreoperativetherapyinlocalizedpancreaticcancer |