Delivery of the selenoprotein thioredoxin reductase 1 to mammalian cells

Delivery of the selenoprotein thioredoxin reductase 1 to mammalian cells

Over-expression of genetically encoded thioredoxin reductase 1 (TrxR1) TrxR1 can be toxic to cells due to the formation of a truncated version of the enzyme. We developed a new mammalian cell-based model to investigate TrxR1 activity. Fusion of the HIV-derived cell penetrating peptide (TAT) enabled...

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Bibliographic Details
Main Authors:	David E. Wright, Tarana Siddika, Ilka U. Heinemann, Patrick O’Donoghue
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Series:	Frontiers in Molecular Biosciences
Subjects:	cell biology cell penetrating peptide enzymology genetic code expansion redox biology selenocysteine
Online Access:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.1031756/full

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