Association of β2-Agonist Receptor Gene Polymorphisms with Acute Exacerbations of COPD: A Prospective Observational Study
Objective. To investigate the relationship between β2-agonist receptor gene polymorphisms and acute exacerbations of chronic obstructive pulmonary disease (COPD). Methods. Retrospective analysis of 99 patients in the respiratory and critical care unit of Fujian Provincial Hospital from 2018 to 2020....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2022-01-01
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| Series: | Emergency Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2022/2711489 |
| _version_ | 1798001751966613504 |
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| author | Fengfeng Lu Nengluan Xu Jianshi Zheng |
| author_facet | Fengfeng Lu Nengluan Xu Jianshi Zheng |
| author_sort | Fengfeng Lu |
| collection | DOAJ |
| description | Objective. To investigate the relationship between β2-agonist receptor gene polymorphisms and acute exacerbations of chronic obstructive pulmonary disease (COPD). Methods. Retrospective analysis of 99 patients in the respiratory and critical care unit of Fujian Provincial Hospital from 2018 to 2020. The clinical characteristics of different genotypes were compared, and the treatments of different genotypes and the analysis of factors associated with acute exacerbations of COPD were compared. Results. During the 12-month follow-up period, 53 patients developed acute exacerbations, with the 16Arg/Arg homozygous requiring significantly more antibiotics and hormones than the other two genotypes; when agonist receptor 16 gene polymorphism was associated with the risk of acute exacerbation, 16Arg/Gly patients had a 5.286-fold increased risk of acute exacerbation (OR = 6.286, 95% CI. 1.476–26.759, P=0.013). 16Arg/Arg patients had a 5.060-fold increased risk of acute exacerbation (OR = 6.060, 95% confidence interval: 1.407–26.161, P=0.016). Conclusion. Acute exacerbation of 16Arg/Arg COPD is very serious; 16Arg/Gly increases the risk of acute exacerbation in COPD patients; and provides help for future treatment and management options of the disease. |
| first_indexed | 2024-04-11T11:41:08Z |
| format | Article |
| id | doaj.art-6124cf20ea264b72850c30b0eeaefbdb |
| institution | Directory Open Access Journal |
| issn | 2090-2859 |
| language | English |
| last_indexed | 2024-04-11T11:41:08Z |
| publishDate | 2022-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Emergency Medicine International |
| spelling | doaj.art-6124cf20ea264b72850c30b0eeaefbdb2022-12-22T04:25:48ZengHindawi LimitedEmergency Medicine International2090-28592022-01-01202210.1155/2022/2711489Association of β2-Agonist Receptor Gene Polymorphisms with Acute Exacerbations of COPD: A Prospective Observational StudyFengfeng Lu0Nengluan Xu1Jianshi Zheng2Department of Pulmonary and Critical Care MedicineDepartment of Pulmonary and Critical Care MedicineDepartment of Pulmonary and Critical Care MedicineObjective. To investigate the relationship between β2-agonist receptor gene polymorphisms and acute exacerbations of chronic obstructive pulmonary disease (COPD). Methods. Retrospective analysis of 99 patients in the respiratory and critical care unit of Fujian Provincial Hospital from 2018 to 2020. The clinical characteristics of different genotypes were compared, and the treatments of different genotypes and the analysis of factors associated with acute exacerbations of COPD were compared. Results. During the 12-month follow-up period, 53 patients developed acute exacerbations, with the 16Arg/Arg homozygous requiring significantly more antibiotics and hormones than the other two genotypes; when agonist receptor 16 gene polymorphism was associated with the risk of acute exacerbation, 16Arg/Gly patients had a 5.286-fold increased risk of acute exacerbation (OR = 6.286, 95% CI. 1.476–26.759, P=0.013). 16Arg/Arg patients had a 5.060-fold increased risk of acute exacerbation (OR = 6.060, 95% confidence interval: 1.407–26.161, P=0.016). Conclusion. Acute exacerbation of 16Arg/Arg COPD is very serious; 16Arg/Gly increases the risk of acute exacerbation in COPD patients; and provides help for future treatment and management options of the disease.http://dx.doi.org/10.1155/2022/2711489 |
| spellingShingle | Fengfeng Lu Nengluan Xu Jianshi Zheng Association of β2-Agonist Receptor Gene Polymorphisms with Acute Exacerbations of COPD: A Prospective Observational Study Emergency Medicine International |
| title | Association of β2-Agonist Receptor Gene Polymorphisms with Acute Exacerbations of COPD: A Prospective Observational Study |
| title_full | Association of β2-Agonist Receptor Gene Polymorphisms with Acute Exacerbations of COPD: A Prospective Observational Study |
| title_fullStr | Association of β2-Agonist Receptor Gene Polymorphisms with Acute Exacerbations of COPD: A Prospective Observational Study |
| title_full_unstemmed | Association of β2-Agonist Receptor Gene Polymorphisms with Acute Exacerbations of COPD: A Prospective Observational Study |
| title_short | Association of β2-Agonist Receptor Gene Polymorphisms with Acute Exacerbations of COPD: A Prospective Observational Study |
| title_sort | association of β2 agonist receptor gene polymorphisms with acute exacerbations of copd a prospective observational study |
| url | http://dx.doi.org/10.1155/2022/2711489 |
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