Successful treatment of multiple intracerebral aspergillosis with voriconazole alone in an Egyptian diabetic patient with autoimmune hemolytic anemia
Abstract Aspergillosis is a common fungus that lives in soil and decaying vegetation. Inhalation of the spores causes infection mostly in immunocompromised patients. Invasive aspergillosis has an extremely high mortality, and a definitive diagnosis requires histopathological evidence of deep tissue...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-10-01
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| Series: | The Egyptian Journal of Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43162-023-00254-9 |
| _version_ | 1797556295571603456 |
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| author | Hamdy Ibrahim Safwat Abdel Maksod Magdy Khorshed Hanan Rady Ahmed Alsisi Adel Mohamed Nasser Fouad Ayman Hamed Mohamed Hosny Alaaa Al Amir |
| author_facet | Hamdy Ibrahim Safwat Abdel Maksod Magdy Khorshed Hanan Rady Ahmed Alsisi Adel Mohamed Nasser Fouad Ayman Hamed Mohamed Hosny Alaaa Al Amir |
| author_sort | Hamdy Ibrahim |
| collection | DOAJ |
| description | Abstract Aspergillosis is a common fungus that lives in soil and decaying vegetation. Inhalation of the spores causes infection mostly in immunocompromised patients. Invasive aspergillosis has an extremely high mortality, and a definitive diagnosis requires histopathological evidence of deep tissue invasion or positive culture; however, this evidence is often difficult to obtain due to the critical nature of the patients in these situations. The sensitivity of culture in this setting is also low. The galactomannan test is a recent antigen–antibody serologic test that depends on detecting an antigen which is a molecule found in the cell wall of aspergillus species. A positive result supports the diagnosis of invasive aspergillosis. We present a case of multiple intracerebral brain abscesses in an immunosuppressed patient due to an aspergillus species diagnosed by the galactomannan test with an excellent response to the treatment with the novel voriconazole alone, without any surgical intervention, and the purpose is to alert the physicians, neurologists, and infectious disease specialists to consider the intracranial aspergillosis among the differential diagnosis of the acute onset encephalitis especially in immunocompromised patients as early diagnosis and treatment may be life-saving. |
| first_indexed | 2024-03-10T17:00:47Z |
| format | Article |
| id | doaj.art-6125065d98dc4692bde90c453f07915a |
| institution | Directory Open Access Journal |
| issn | 2090-9098 |
| language | English |
| last_indexed | 2024-03-10T17:00:47Z |
| publishDate | 2023-10-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Internal Medicine |
| spelling | doaj.art-6125065d98dc4692bde90c453f07915a2023-11-20T10:58:47ZengSpringerOpenThe Egyptian Journal of Internal Medicine2090-90982023-10-013511810.1186/s43162-023-00254-9Successful treatment of multiple intracerebral aspergillosis with voriconazole alone in an Egyptian diabetic patient with autoimmune hemolytic anemiaHamdy Ibrahim0Safwat Abdel Maksod1Magdy Khorshed2Hanan Rady3Ahmed Alsisi4Adel Mohamed5Nasser Fouad6Ayman Hamed7Mohamed Hosny8Alaaa Al Amir9Egypt Ministry of Health and PopulationEgypt Ministry of Health and PopulationEgypt Ministry of Health and PopulationEgypt Ministry of Health and PopulationEgypt Ministry of Health and PopulationEgypt Ministry of Health and PopulationEgypt Ministry of Health and PopulationEgypt Ministry of Health and PopulationEgypt Ministry of Health and PopulationEgypt Ministry of Health and PopulationAbstract Aspergillosis is a common fungus that lives in soil and decaying vegetation. Inhalation of the spores causes infection mostly in immunocompromised patients. Invasive aspergillosis has an extremely high mortality, and a definitive diagnosis requires histopathological evidence of deep tissue invasion or positive culture; however, this evidence is often difficult to obtain due to the critical nature of the patients in these situations. The sensitivity of culture in this setting is also low. The galactomannan test is a recent antigen–antibody serologic test that depends on detecting an antigen which is a molecule found in the cell wall of aspergillus species. A positive result supports the diagnosis of invasive aspergillosis. We present a case of multiple intracerebral brain abscesses in an immunosuppressed patient due to an aspergillus species diagnosed by the galactomannan test with an excellent response to the treatment with the novel voriconazole alone, without any surgical intervention, and the purpose is to alert the physicians, neurologists, and infectious disease specialists to consider the intracranial aspergillosis among the differential diagnosis of the acute onset encephalitis especially in immunocompromised patients as early diagnosis and treatment may be life-saving.https://doi.org/10.1186/s43162-023-00254-9Intracerebral aspergillosisVoriconazoleGalactomannan testAutoimmune hemolytic anemia |
| spellingShingle | Hamdy Ibrahim Safwat Abdel Maksod Magdy Khorshed Hanan Rady Ahmed Alsisi Adel Mohamed Nasser Fouad Ayman Hamed Mohamed Hosny Alaaa Al Amir Successful treatment of multiple intracerebral aspergillosis with voriconazole alone in an Egyptian diabetic patient with autoimmune hemolytic anemia The Egyptian Journal of Internal Medicine Intracerebral aspergillosis Voriconazole Galactomannan test Autoimmune hemolytic anemia |
| title | Successful treatment of multiple intracerebral aspergillosis with voriconazole alone in an Egyptian diabetic patient with autoimmune hemolytic anemia |
| title_full | Successful treatment of multiple intracerebral aspergillosis with voriconazole alone in an Egyptian diabetic patient with autoimmune hemolytic anemia |
| title_fullStr | Successful treatment of multiple intracerebral aspergillosis with voriconazole alone in an Egyptian diabetic patient with autoimmune hemolytic anemia |
| title_full_unstemmed | Successful treatment of multiple intracerebral aspergillosis with voriconazole alone in an Egyptian diabetic patient with autoimmune hemolytic anemia |
| title_short | Successful treatment of multiple intracerebral aspergillosis with voriconazole alone in an Egyptian diabetic patient with autoimmune hemolytic anemia |
| title_sort | successful treatment of multiple intracerebral aspergillosis with voriconazole alone in an egyptian diabetic patient with autoimmune hemolytic anemia |
| topic | Intracerebral aspergillosis Voriconazole Galactomannan test Autoimmune hemolytic anemia |
| url | https://doi.org/10.1186/s43162-023-00254-9 |
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