Knocking-out the Siah2 E3 ubiquitin ligase prevents mitochondrial NCX3 degradation, regulates mitochondrial fission and fusion, and restores mitochondrial function in hypoxic neurons

Knocking-out the Siah2 E3 ubiquitin ligase prevents mitochondrial NCX3 degradation, regulates mitochondrial fission and fusion, and restores mitochondrial function in hypoxic neurons

Abstract Background Na+/Ca2 + exchanger isoform 3 (NCX3) regulates mitochondrial Ca2+ handling through the outer mitochondrial membrane (OMM) and promotes neuronal survival during oxygen and glucose deprivation (OGD). Conversely, Seven In-Absentia Homolog 2 (Siah2), an E3-ubiquitin ligase, which is...

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Bibliographic Details
Main Authors: Maria Josè Sisalli, Gaetano Ianniello, Claudia Savoia, Ornella Cuomo, Lucio Annunziato, Antonella Scorziello
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Cell Communication and Signaling
Subjects:
Mitochondria
siah2
NCX3, cortical neurons
Hypoxia
Online Access:http://link.springer.com/article/10.1186/s12964-020-0529-x

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