Real-time tracking of drug binding to influenza A M2 reveals a high energy barrier
The drug Rimantadine binds to two different sites in the M2 protein from influenza A, a peripheral site and a pore site that is the primary site of efficacy. It remained enigmatic that pore binding did not occur in certain detergent micelles, and in particular incomplete binding was observed in a mi...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2023-12-01
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Series: | Journal of Structural Biology: X |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2590152423000065 |