Deficiency of Senescence Marker Protein 30 Exacerbates Cardiac Injury after Ischemia/Reperfusion

Deficiency of Senescence Marker Protein 30 Exacerbates Cardiac Injury after Ischemia/Reperfusion

Early myocardial reperfusion is an effective therapy but ischemia/reperfusion (I/R) causes lethal myocardial injury. The aging heart was reported to show greater cardiac damage after I/R injury than that observed in young hearts. Senescence marker protein 30 (SMP30), whose expression decreases with...

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Bibliographic Details
Main Authors: Shinpei Kadowaki, Tetsuro Shishido, Toshiki Sasaki, Takayuki Sugai, Taro Narumi, Yuki Honda, Yoichiro Otaki, Daisuke Kinoshita, Tetsuya Takahashi, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Takuya Miyamoto, Tetsu Watanabe, Akihiko Ishigami, Yasuchika Takeishi, Isao Kubota
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:International Journal of Molecular Sciences
Subjects:
ischemia reperfusion
SMP30
cardiomyocyte
GSK-3β
Online Access:http://www.mdpi.com/1422-0067/17/4/542

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