Coordinated changes in gene expression kinetics underlie both mouse and human erythroid maturation

Coordinated changes in gene expression kinetics underlie both mouse and human erythroid maturation

Abstract Background Single-cell technologies are transforming biomedical research, including the recent demonstration that unspliced pre-mRNA present in single-cell RNA-Seq permits prediction of future expression states. Here we apply this RNA velocity concept to an extended timecourse dataset cover...

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Bibliographic Details
Main Authors: Melania Barile, Ivan Imaz-Rosshandler, Isabella Inzani, Shila Ghazanfar, Jennifer Nichols, John C. Marioni, Carolina Guibentif, Berthold Göttgens
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Genome Biology
Subjects:
RNA velocity
Gastrulation
Erythropoiesis
Gata1
Online Access:https://doi.org/10.1186/s13059-021-02414-y

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