Hyaluronic Acid Correlates With Bone Metastasis and Predicts Poor Prognosis in Small-Cell Lung Cancer Patients

Hyaluronic Acid Correlates With Bone Metastasis and Predicts Poor Prognosis in Small-Cell Lung Cancer Patients

BackgroundHyaluronan (HA) is one of the essential elements of the extracellular matrix (ECM), involved in the onset of metastasis in various tumors. The interaction and binding of the ligand–receptor HA/cluster of differentiation-44 (CD44) regulate the physical and biochemical properties of the ECM,...

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Bibliographic Details
Main Authors: Cong Zhao, Zhiyun Zhang, Xingsheng Hu, Lina Zhang, Yanxia Liu, Ying Wang, Yi Guo, Tongmei Zhang, Weiying Li, Baolan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Endocrinology
Subjects:
hyaluronic acid
SCLC
bone metastasis
predictive factor
survival rate
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.785192/full

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