The Role of Probiotics in the Prevention of <i>Clostridioides difficile</i> Infection in Patients with Chronic Kidney Disease
In patients suffering from chronic kidney disease (CKD), substantial unfavourable alterations in the intestinal microbiota composition, i.e., dysbiosis, have been noted. The main causes of such dysbiosis among others are insufficient dietary fibre content in the diet, fluid restrictions, medications...
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| Format: | Article |
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MDPI AG
2024-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/16/5/671 |
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| author | Sylwia Dudzicz-Gojowy Andrzej Więcek Marcin Adamczak |
| author_facet | Sylwia Dudzicz-Gojowy Andrzej Więcek Marcin Adamczak |
| author_sort | Sylwia Dudzicz-Gojowy |
| collection | DOAJ |
| description | In patients suffering from chronic kidney disease (CKD), substantial unfavourable alterations in the intestinal microbiota composition, i.e., dysbiosis, have been noted. The main causes of such dysbiosis among others are insufficient dietary fibre content in the diet, fluid restrictions, medications used, and physical activity limitation. One clinically important consequence of dysbiosis in CKD patients is high risk of <i>Clostridioides difficile</i> infection (CDI). In observational studies, it was found that CDI is more frequent in CKD patients than in the general population. This appears to be related to high hospitalization rate and more often antibiotic therapy use, leading up to the occurrence of dysbiosis. Therefore, the use of probiotics in CKD patients may avert changes in the intestinal microbiota, which is the major risk factor of CDI. The aim of this review paper is to summarize the actual knowledge concerning the use of probiotics in CDI prevention in CKD patients in the context of CDI prevention in the general population. |
| first_indexed | 2024-04-25T00:22:07Z |
| format | Article |
| id | doaj.art-612ec840330c415d9b68e3df2534fd2a |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-04-25T00:22:07Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
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| series | Nutrients |
| spelling | doaj.art-612ec840330c415d9b68e3df2534fd2a2024-03-12T16:52:08ZengMDPI AGNutrients2072-66432024-02-0116567110.3390/nu16050671The Role of Probiotics in the Prevention of <i>Clostridioides difficile</i> Infection in Patients with Chronic Kidney DiseaseSylwia Dudzicz-Gojowy0Andrzej Więcek1Marcin Adamczak2Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, 40-027 Katowice, PolandDepartment of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, 40-027 Katowice, PolandDepartment of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, 40-027 Katowice, PolandIn patients suffering from chronic kidney disease (CKD), substantial unfavourable alterations in the intestinal microbiota composition, i.e., dysbiosis, have been noted. The main causes of such dysbiosis among others are insufficient dietary fibre content in the diet, fluid restrictions, medications used, and physical activity limitation. One clinically important consequence of dysbiosis in CKD patients is high risk of <i>Clostridioides difficile</i> infection (CDI). In observational studies, it was found that CDI is more frequent in CKD patients than in the general population. This appears to be related to high hospitalization rate and more often antibiotic therapy use, leading up to the occurrence of dysbiosis. Therefore, the use of probiotics in CKD patients may avert changes in the intestinal microbiota, which is the major risk factor of CDI. The aim of this review paper is to summarize the actual knowledge concerning the use of probiotics in CDI prevention in CKD patients in the context of CDI prevention in the general population.https://www.mdpi.com/2072-6643/16/5/671chronic kidney disease<i>Clostridioides difficile</i> infectionprobiotics |
| spellingShingle | Sylwia Dudzicz-Gojowy Andrzej Więcek Marcin Adamczak The Role of Probiotics in the Prevention of <i>Clostridioides difficile</i> Infection in Patients with Chronic Kidney Disease Nutrients chronic kidney disease <i>Clostridioides difficile</i> infection probiotics |
| title | The Role of Probiotics in the Prevention of <i>Clostridioides difficile</i> Infection in Patients with Chronic Kidney Disease |
| title_full | The Role of Probiotics in the Prevention of <i>Clostridioides difficile</i> Infection in Patients with Chronic Kidney Disease |
| title_fullStr | The Role of Probiotics in the Prevention of <i>Clostridioides difficile</i> Infection in Patients with Chronic Kidney Disease |
| title_full_unstemmed | The Role of Probiotics in the Prevention of <i>Clostridioides difficile</i> Infection in Patients with Chronic Kidney Disease |
| title_short | The Role of Probiotics in the Prevention of <i>Clostridioides difficile</i> Infection in Patients with Chronic Kidney Disease |
| title_sort | role of probiotics in the prevention of i clostridioides difficile i infection in patients with chronic kidney disease |
| topic | chronic kidney disease <i>Clostridioides difficile</i> infection probiotics |
| url | https://www.mdpi.com/2072-6643/16/5/671 |
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