Relative Contributions of Solubility and Mobility to the Stability of Amorphous Solid Dispersions of Poorly Soluble Drugs: A Molecular Dynamics Simulation Study

Relative Contributions of Solubility and Mobility to the Stability of Amorphous Solid Dispersions of Poorly Soluble Drugs: A Molecular Dynamics Simulation Study

Amorphous solid dispersions are considered a promising formulation strategy for the oral delivery of poorly soluble drugs. The limiting factor for the applicability of this approach is the physical (in)stability of the amorphous phase in solid samples. Minimizing the risk of reduced shelf life for a...

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Bibliographic Details
Main Authors: Michael Brunsteiner, Johannes Khinast, Amrit Paudel
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Pharmaceutics
Subjects:
molecular dynamics simulation
amorphous
physical stability
hydrogen-bond
molecular mobility
mixing energy
molecular interactions
Online Access:http://www.mdpi.com/1999-4923/10/3/101

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