Super-High Magnification Dermoscopy in 190 Clinically Atypical Pigmented Lesions
Super-high (×400) magnification dermoscopy (D400) is a new non-invasive imaging technique that has been shown to add information for the differential diagnosis of melanocytic lesions in a pilot study. Our study aimed to confirm if D400 can add details for the discrimination of clinically atypical ne...
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MDPI AG
2023-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/13/2238 |
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| author | Elisa Cinotti Vittoria Cioppa Linda Tognetti Jean Luc Perrot Renato Rossi Matteo Gnone Alessandra Cartocci Pietro Rubegni Giulio Cortonesi |
| author_facet | Elisa Cinotti Vittoria Cioppa Linda Tognetti Jean Luc Perrot Renato Rossi Matteo Gnone Alessandra Cartocci Pietro Rubegni Giulio Cortonesi |
| author_sort | Elisa Cinotti |
| collection | DOAJ |
| description | Super-high (×400) magnification dermoscopy (D400) is a new non-invasive imaging technique that has been shown to add information for the differential diagnosis of melanocytic lesions in a pilot study. Our study aimed to confirm if D400 can add details for the discrimination of clinically atypical nevus and melanoma. This is a retrospective observational, multicentric study enrolling patients who received ×20 (D20) and ×400 (D400) magnification dermoscopic examinations of pigmented skin lesions. Dermoscopic images were retrospectively evaluated by three observers for the presence/absence of nine D20 and twenty D400 dermoscopic features defined in the previous pilot study. Univariate and multivariate analyses were carried out to find predictors of benign and malignant behaviors. At D20, an atypical pigment network, blue-whitish veil, atypical vascular pattern, regression, and homogenous pattern were more frequent in melanoma than in nevi (<i>p</i> < 0.001). At D400, melanoma showed more frequently than benign lesions, melanocytes with an irregular arrangement and irregular in shape and size (<i>p</i> < 0.001). A network with edged papillae was more frequent in benign lesions than melanomas (<i>p</i> < 0.001). Our study confirms that D400 can identify melanocytes with an irregular arrangement, and irregularities in shape and size in melanomas, adding information to the conventional D20 examination. |
| first_indexed | 2024-03-11T01:43:58Z |
| format | Article |
| id | doaj.art-612f9d55657a4a81a5ca3349bfbf1fac |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T01:43:58Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-612f9d55657a4a81a5ca3349bfbf1fac2023-11-18T16:21:56ZengMDPI AGDiagnostics2075-44182023-06-011313223810.3390/diagnostics13132238Super-High Magnification Dermoscopy in 190 Clinically Atypical Pigmented LesionsElisa Cinotti0Vittoria Cioppa1Linda Tognetti2Jean Luc Perrot3Renato Rossi4Matteo Gnone5Alessandra Cartocci6Pietro Rubegni7Giulio Cortonesi8Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, 53100 Siena, ItalyDepartment of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, 53100 Siena, ItalyDepartment of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, 53100 Siena, ItalyDepartment of Dermatology, University Hospital of Saint-Etienne, 42055 Saint-Etienne, FranceDepartment of Dermatology, Skin Center Senigallia, 60019 Ancona, ItalyDermatology Private Practice, 16121 Genoa, ItalyDepartment of Medical Biotechnology, University of Siena, 53100 Siena, ItalyDepartment of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, 53100 Siena, ItalyDepartment of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, 53100 Siena, ItalySuper-high (×400) magnification dermoscopy (D400) is a new non-invasive imaging technique that has been shown to add information for the differential diagnosis of melanocytic lesions in a pilot study. Our study aimed to confirm if D400 can add details for the discrimination of clinically atypical nevus and melanoma. This is a retrospective observational, multicentric study enrolling patients who received ×20 (D20) and ×400 (D400) magnification dermoscopic examinations of pigmented skin lesions. Dermoscopic images were retrospectively evaluated by three observers for the presence/absence of nine D20 and twenty D400 dermoscopic features defined in the previous pilot study. Univariate and multivariate analyses were carried out to find predictors of benign and malignant behaviors. At D20, an atypical pigment network, blue-whitish veil, atypical vascular pattern, regression, and homogenous pattern were more frequent in melanoma than in nevi (<i>p</i> < 0.001). At D400, melanoma showed more frequently than benign lesions, melanocytes with an irregular arrangement and irregular in shape and size (<i>p</i> < 0.001). A network with edged papillae was more frequent in benign lesions than melanomas (<i>p</i> < 0.001). Our study confirms that D400 can identify melanocytes with an irregular arrangement, and irregularities in shape and size in melanomas, adding information to the conventional D20 examination.https://www.mdpi.com/2075-4418/13/13/2238dermoscopyhigh magnificationsuper-high magnificationkeratinocytemelanocytemelanoma |
| spellingShingle | Elisa Cinotti Vittoria Cioppa Linda Tognetti Jean Luc Perrot Renato Rossi Matteo Gnone Alessandra Cartocci Pietro Rubegni Giulio Cortonesi Super-High Magnification Dermoscopy in 190 Clinically Atypical Pigmented Lesions Diagnostics dermoscopy high magnification super-high magnification keratinocyte melanocyte melanoma |
| title | Super-High Magnification Dermoscopy in 190 Clinically Atypical Pigmented Lesions |
| title_full | Super-High Magnification Dermoscopy in 190 Clinically Atypical Pigmented Lesions |
| title_fullStr | Super-High Magnification Dermoscopy in 190 Clinically Atypical Pigmented Lesions |
| title_full_unstemmed | Super-High Magnification Dermoscopy in 190 Clinically Atypical Pigmented Lesions |
| title_short | Super-High Magnification Dermoscopy in 190 Clinically Atypical Pigmented Lesions |
| title_sort | super high magnification dermoscopy in 190 clinically atypical pigmented lesions |
| topic | dermoscopy high magnification super-high magnification keratinocyte melanocyte melanoma |
| url | https://www.mdpi.com/2075-4418/13/13/2238 |
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