In vitro transdermal delivery of propranolol hydrochloride through rat skin from various niosomal formulations
Objective(s): The purpose of the present study was to prepare and to evaluate a novel niosome as transdermal drug delivery system for propranolol hydrochloride and to compare the in vitro efficiency of niosome by either thin film hydration or hand shaking method. Materials and Methods: Niosomes we...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2013-09-01
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| Series: | Nanomedicine Journal |
| Online Access: | http://nmj.mums.ac.ir/?_action=showPDF&article=1709&_ob=d032be7573624e1aba00101ac9d1b375&fileName=full_text.pdf |
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| author | Eskandar Moghimipour Anayatollah Salimi Hassan Dagheri |
| author_facet | Eskandar Moghimipour Anayatollah Salimi Hassan Dagheri |
| author_sort | Eskandar Moghimipour |
| collection | DOAJ |
| description | Objective(s): The purpose of the present study was to prepare and to evaluate a novel niosome as transdermal drug delivery system for propranolol hydrochloride and to compare the in vitro efficiency of niosome by either thin film hydration or hand shaking method. Materials and Methods: Niosomes were prepared by Thin Film Hydration (TFH) or Hand Shaking (HS) method. Propranolol niosomes were prepared using different surfactants (span20, 80) ratios and a constant cholesterol concentration. In vitro characterization of niosomes included microscopical observation, size distribution, laser light scattering evaluation, stability of propranolol niosomes and permeability of formulations in phosphate buffer (pH=7) through rat abdominal skin. Results: The percentage of entrapment efficiency (%EE) increased with increase in surfactant concentration in all formulations. Among them, F3 formulation (containing span80:cholesterol ratio of 3:1) showed the highest entrapment efficiency (86.74±2.01%), Jss (6.33μg/cm2.h) and permeability coefficient ( . By increasing the percentage of entrapment efficiency (resulting in increase in surfactant concentration), the drug released time is not prolonged. Among all the formulations, F4 needed more time for maximum drug release. Among these formulations, F4 was also found to have the maximum vesicle size as compared to other formulations. It was observed that niosomal suspension prepared from span 80 was more stable than span 20. Conclusion: This study demonstrates that niosomal formulations may offer a promise transdermal delivery of propranolol which improves drug efficiency and can be used for controlled delivery of propranolol |
| first_indexed | 2024-12-12T10:33:36Z |
| format | Article |
| id | doaj.art-61318c26c7e4493580b47aa3b1af7f61 |
| institution | Directory Open Access Journal |
| issn | 2322-3049 2322-5904 |
| language | English |
| last_indexed | 2024-12-12T10:33:36Z |
| publishDate | 2013-09-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Nanomedicine Journal |
| spelling | doaj.art-61318c26c7e4493580b47aa3b1af7f612022-12-22T00:27:17ZengMashhad University of Medical SciencesNanomedicine Journal2322-30492322-59042013-09-01121121201709In vitro transdermal delivery of propranolol hydrochloride through rat skin from various niosomal formulationsEskandar Moghimipour0Anayatollah Salimi1Hassan Dagheri21Nanotechnology research center, Jundishapur University of Medical Sciences, Ahvaz, Iran 2Department of Pharmaceutics, School of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, Iran1Nanotechnology research center, Jundishapur University of Medical Sciences, Ahvaz, Iran 2Department of Pharmaceutics, School of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, Iran2Department of Pharmaceutics, School of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, IranObjective(s): The purpose of the present study was to prepare and to evaluate a novel niosome as transdermal drug delivery system for propranolol hydrochloride and to compare the in vitro efficiency of niosome by either thin film hydration or hand shaking method. Materials and Methods: Niosomes were prepared by Thin Film Hydration (TFH) or Hand Shaking (HS) method. Propranolol niosomes were prepared using different surfactants (span20, 80) ratios and a constant cholesterol concentration. In vitro characterization of niosomes included microscopical observation, size distribution, laser light scattering evaluation, stability of propranolol niosomes and permeability of formulations in phosphate buffer (pH=7) through rat abdominal skin. Results: The percentage of entrapment efficiency (%EE) increased with increase in surfactant concentration in all formulations. Among them, F3 formulation (containing span80:cholesterol ratio of 3:1) showed the highest entrapment efficiency (86.74±2.01%), Jss (6.33μg/cm2.h) and permeability coefficient ( . By increasing the percentage of entrapment efficiency (resulting in increase in surfactant concentration), the drug released time is not prolonged. Among all the formulations, F4 needed more time for maximum drug release. Among these formulations, F4 was also found to have the maximum vesicle size as compared to other formulations. It was observed that niosomal suspension prepared from span 80 was more stable than span 20. Conclusion: This study demonstrates that niosomal formulations may offer a promise transdermal delivery of propranolol which improves drug efficiency and can be used for controlled delivery of propranololhttp://nmj.mums.ac.ir/?_action=showPDF&article=1709&_ob=d032be7573624e1aba00101ac9d1b375&fileName=full_text.pdf |
| spellingShingle | Eskandar Moghimipour Anayatollah Salimi Hassan Dagheri In vitro transdermal delivery of propranolol hydrochloride through rat skin from various niosomal formulations Nanomedicine Journal |
| title | In vitro transdermal delivery of propranolol hydrochloride through rat skin from various niosomal formulations |
| title_full | In vitro transdermal delivery of propranolol hydrochloride through rat skin from various niosomal formulations |
| title_fullStr | In vitro transdermal delivery of propranolol hydrochloride through rat skin from various niosomal formulations |
| title_full_unstemmed | In vitro transdermal delivery of propranolol hydrochloride through rat skin from various niosomal formulations |
| title_short | In vitro transdermal delivery of propranolol hydrochloride through rat skin from various niosomal formulations |
| title_sort | in vitro transdermal delivery of propranolol hydrochloride through rat skin from various niosomal formulations |
| url | http://nmj.mums.ac.ir/?_action=showPDF&article=1709&_ob=d032be7573624e1aba00101ac9d1b375&fileName=full_text.pdf |
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