Association between Malnutrition and Coronary Plaque Characteristics in Patients with Acute Coronary Syndrome: An Optical Coherence Tomography Study
Background: Malnutrition has a negative impact on patients with arteriosclerotic cardiovascular disease (ASCVD); however, only a few studies have confirmed the effect of malnutrition on atherosclerosis. We aimed to investigate the association between malnutrition and vulnerable plaques via optical c...
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| Format: | Article |
| Language: | English |
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IMR Press
2023-10-01
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| Series: | Reviews in Cardiovascular Medicine |
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| Online Access: | https://www.imrpress.com/journal/RCM/24/10/10.31083/j.rcm2410303 |
| _version_ | 1797643463324336128 |
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| author | Haihao Yan Wenjing Yao Qian Yang Congcong Li Zhenyu Wang Tianxing Li Yanhong Li Kexin Song Feifei Zhang Yi Dang |
| author_facet | Haihao Yan Wenjing Yao Qian Yang Congcong Li Zhenyu Wang Tianxing Li Yanhong Li Kexin Song Feifei Zhang Yi Dang |
| author_sort | Haihao Yan |
| collection | DOAJ |
| description | Background: Malnutrition has a negative impact on patients with arteriosclerotic cardiovascular disease (ASCVD); however, only a few studies have confirmed the effect of malnutrition on atherosclerosis. We aimed to investigate the association between malnutrition and vulnerable plaques via optical coherence tomography (OCT). Methods: Overall, 142 acute coronary syndrome (ACS) patients were included in this study. Malnutrition was assessed using the Controlled Nutritional Status Score (CONUT), and plaque vulnerability was measured using OCT. Finally, patients were divided into four groups according to their CONUT scores and body mass index (BMI) ≥25.0 or not, to further compare the effects of both factors on plaque characteristics in patients. Results: OCT results showed that there were significant differences in plaque rupture, thin cap fibroatheroma (TCFA), minimal fiber cap thickness (FCT), thrombus, and macrophage infiltration between different nutritional states [Absent (0–1) vs Mild (2–4) vs Moderate (5–8), plaque rupture: 34.8% vs 52.5% vs 66.7%, p = 0.038; TCFA: 10.1% vs 24.6% vs 33.3%, p = 0.039; minimal FCT: 125.0 vs 110.4 vs 96.9, p = 0.022; thrombus: 50.7% vs 70.5% vs 83.3%, p = 0.019]. Multivariate logistic regression showed that malnutrition was a significant predictor of plaque vulnerability. Plaque rupture: CONUT score (odds ratio [OR]: 1.448, 95% confidence interval [CI]: 1.136–1.845, p = 0.003), Mild (OR: 1.981, 95% CI: 0.932–4.210, p = 0.075), and Moderate (OR: 4.375, 95% CI: 1.048–18.255, p = 0.043); TCFA: CONUT score (OR: 1.334, 95% CI: 1.029–1.730, p = 0.030), Mild (OR: 3.518, 95% CI: 1.251–9.897, p = 0.017), and Moderate (OR: 4.863, 95% CI: 1.019–23.208, p = 0.047); and macrophage: CONUT score (OR: 1.343, 95% CI: 1.060–1.700, p = 0.015), Mild (OR: 3.016, 95% CI: 1.305–6.974, p = 0.010), and Moderate (OR: 4.637, 95% CI: 1.159–18.552, p = 0.030). Combined CONUT score and BMI showed an independent association with macrophages in the malnourished and overweight group (OR: 4.010, 95% CI: 1.188–13.537, p = 0.025). Conclusions: Malnutrition is a predictor of vulnerable plaques and is associated with inflammatory progression. |
| first_indexed | 2024-03-11T14:16:15Z |
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| id | doaj.art-6132a6b418354c25814fcbb54f61f2fb |
| institution | Directory Open Access Journal |
| issn | 1530-6550 |
| language | English |
| last_indexed | 2024-03-11T14:16:15Z |
| publishDate | 2023-10-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj.art-6132a6b418354c25814fcbb54f61f2fb2023-11-01T06:42:26ZengIMR PressReviews in Cardiovascular Medicine1530-65502023-10-01241030310.31083/j.rcm2410303S1530-6550(23)01078-5Association between Malnutrition and Coronary Plaque Characteristics in Patients with Acute Coronary Syndrome: An Optical Coherence Tomography StudyHaihao Yan0Wenjing Yao1Qian Yang2Congcong Li3Zhenyu Wang4Tianxing Li5Yanhong Li6Kexin Song7Feifei Zhang8Yi Dang9Department of Internal Medicine, Graduate School of Hebei Medical University, 050017 Shijiazhuang, Hebei, ChinaDepartment of Cardiology Center, Hebei General Hospital, 050051 Shijiazhuang, Hebei, ChinaDepartment of Cardiology Center, Hebei General Hospital, 050051 Shijiazhuang, Hebei, ChinaDepartment of Internal Medicine, Graduate School of Hebei Medical University, 050017 Shijiazhuang, Hebei, ChinaDepartment of Internal Medicine, Graduate School of Hebei Medical University, 050017 Shijiazhuang, Hebei, ChinaDepartment of Graduate School of Hebei North University, 075000 Zhangjiakou, Hebei, ChinaDepartment of Internal Medicine, Graduate School of Hebei Medical University, 050017 Shijiazhuang, Hebei, ChinaDepartment of Internal Medicine, Graduate School of Hebei Medical University, 050017 Shijiazhuang, Hebei, ChinaDepartment of Cardiology Center, Hebei General Hospital, 050051 Shijiazhuang, Hebei, ChinaDepartment of Cardiology Center, Hebei General Hospital, 050051 Shijiazhuang, Hebei, ChinaBackground: Malnutrition has a negative impact on patients with arteriosclerotic cardiovascular disease (ASCVD); however, only a few studies have confirmed the effect of malnutrition on atherosclerosis. We aimed to investigate the association between malnutrition and vulnerable plaques via optical coherence tomography (OCT). Methods: Overall, 142 acute coronary syndrome (ACS) patients were included in this study. Malnutrition was assessed using the Controlled Nutritional Status Score (CONUT), and plaque vulnerability was measured using OCT. Finally, patients were divided into four groups according to their CONUT scores and body mass index (BMI) ≥25.0 or not, to further compare the effects of both factors on plaque characteristics in patients. Results: OCT results showed that there were significant differences in plaque rupture, thin cap fibroatheroma (TCFA), minimal fiber cap thickness (FCT), thrombus, and macrophage infiltration between different nutritional states [Absent (0–1) vs Mild (2–4) vs Moderate (5–8), plaque rupture: 34.8% vs 52.5% vs 66.7%, p = 0.038; TCFA: 10.1% vs 24.6% vs 33.3%, p = 0.039; minimal FCT: 125.0 vs 110.4 vs 96.9, p = 0.022; thrombus: 50.7% vs 70.5% vs 83.3%, p = 0.019]. Multivariate logistic regression showed that malnutrition was a significant predictor of plaque vulnerability. Plaque rupture: CONUT score (odds ratio [OR]: 1.448, 95% confidence interval [CI]: 1.136–1.845, p = 0.003), Mild (OR: 1.981, 95% CI: 0.932–4.210, p = 0.075), and Moderate (OR: 4.375, 95% CI: 1.048–18.255, p = 0.043); TCFA: CONUT score (OR: 1.334, 95% CI: 1.029–1.730, p = 0.030), Mild (OR: 3.518, 95% CI: 1.251–9.897, p = 0.017), and Moderate (OR: 4.863, 95% CI: 1.019–23.208, p = 0.047); and macrophage: CONUT score (OR: 1.343, 95% CI: 1.060–1.700, p = 0.015), Mild (OR: 3.016, 95% CI: 1.305–6.974, p = 0.010), and Moderate (OR: 4.637, 95% CI: 1.159–18.552, p = 0.030). Combined CONUT score and BMI showed an independent association with macrophages in the malnourished and overweight group (OR: 4.010, 95% CI: 1.188–13.537, p = 0.025). Conclusions: Malnutrition is a predictor of vulnerable plaques and is associated with inflammatory progression.https://www.imrpress.com/journal/RCM/24/10/10.31083/j.rcm2410303malnutritioncontrolled nutritional status scoreacute coronary syndromeplaque characteristicoptical coherence tomography |
| spellingShingle | Haihao Yan Wenjing Yao Qian Yang Congcong Li Zhenyu Wang Tianxing Li Yanhong Li Kexin Song Feifei Zhang Yi Dang Association between Malnutrition and Coronary Plaque Characteristics in Patients with Acute Coronary Syndrome: An Optical Coherence Tomography Study Reviews in Cardiovascular Medicine malnutrition controlled nutritional status score acute coronary syndrome plaque characteristic optical coherence tomography |
| title | Association between Malnutrition and Coronary Plaque Characteristics in Patients with Acute Coronary Syndrome: An Optical Coherence Tomography Study |
| title_full | Association between Malnutrition and Coronary Plaque Characteristics in Patients with Acute Coronary Syndrome: An Optical Coherence Tomography Study |
| title_fullStr | Association between Malnutrition and Coronary Plaque Characteristics in Patients with Acute Coronary Syndrome: An Optical Coherence Tomography Study |
| title_full_unstemmed | Association between Malnutrition and Coronary Plaque Characteristics in Patients with Acute Coronary Syndrome: An Optical Coherence Tomography Study |
| title_short | Association between Malnutrition and Coronary Plaque Characteristics in Patients with Acute Coronary Syndrome: An Optical Coherence Tomography Study |
| title_sort | association between malnutrition and coronary plaque characteristics in patients with acute coronary syndrome an optical coherence tomography study |
| topic | malnutrition controlled nutritional status score acute coronary syndrome plaque characteristic optical coherence tomography |
| url | https://www.imrpress.com/journal/RCM/24/10/10.31083/j.rcm2410303 |
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