Antiatherosclerotic Phenotype of Perivascular Adipose Tissue Surrounding the Saphenous Vein in Coronary Artery Bypass Grafting
Background Perivascular adipose tissue (PVAT) is associated with metabolically driven chronic inflammation called metaflammation, which contributes to vascular function and the pathogenesis of vascular disease. The saphenous vein (SV) is commonly used as an essential conduit in coronary artery bypas...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-04-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.120.018905 |
| _version_ | 1811332697139707904 |
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| author | Takuma Mikami Masato Furuhashi Akiko Sakai Ryosuke Numaguchi Ryo Harada Syuichi Naraoka Takeshi Kamada Yukimura Higashiura Marenao Tanaka Shunsuke Ohori Taku Sakurada Masanori Nakamura Yutaka Iba Joji Fukada Tetsuji Miura Nobuyoshi Kawaharada |
| author_facet | Takuma Mikami Masato Furuhashi Akiko Sakai Ryosuke Numaguchi Ryo Harada Syuichi Naraoka Takeshi Kamada Yukimura Higashiura Marenao Tanaka Shunsuke Ohori Taku Sakurada Masanori Nakamura Yutaka Iba Joji Fukada Tetsuji Miura Nobuyoshi Kawaharada |
| author_sort | Takuma Mikami |
| collection | DOAJ |
| description | Background Perivascular adipose tissue (PVAT) is associated with metabolically driven chronic inflammation called metaflammation, which contributes to vascular function and the pathogenesis of vascular disease. The saphenous vein (SV) is commonly used as an essential conduit in coronary artery bypass grafting, but the long‐term patency of SV grafts is a crucial issue. The use of the novel “no‐touch” technique of SV harvesting together with its surrounding tissue has been reported to result in good long‑term graft patency of SV grafts. Herein, we investigated whether PVAT surrounding the SV (SV‐PVAT) has distinct phenotypes compared with other PVATs of vessels. Methods and Results Fat pads were sampled from 48 patients (male/female, 32/16; age, 72±8 years) with coronary artery disease who underwent elective coronary artery bypass grafting. Adipocyte size in SV‐PVAT was significantly larger than the sizes in PVATs surrounding the internal thoracic artery, coronary artery, and aorta. SV‐PVAT and PVAT surrounding the internal thoracic artery had smaller extents of fibrosis, decreased gene expression levels of fibrosis‐related markers, and less metaflammation, as indicated by a significantly smaller extent of cluster of differentiation 11c–positive M1 macrophage infiltration, higher gene expression level of adiponectin, and lower gene expression levels of inflammatory cytokines, than did PVATs surrounding the coronary artery and aorta. Expression patterns of adipocyte developmental and pattern‐forming genes were totally different among the PVATs of the vessels. Conclusions The phenotype of SV‐PVAT, which may result from inherent differences in adipocytes, is closer to that of PVAT surrounding the internal thoracic artery than that of PVAT surrounding the coronary artery or that of PVAT surrounding the aorta. SV‐PVAT has less metaflammation and consecutive adipose tissue remodeling, which may contribute to high long‐term patency of grafting when the no‐touch technique of SV harvesting is used. |
| first_indexed | 2024-04-13T16:39:56Z |
| format | Article |
| id | doaj.art-61332fe3e9b649838fe826f4ba9aed9c |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-13T16:39:56Z |
| publishDate | 2021-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-61332fe3e9b649838fe826f4ba9aed9c2022-12-22T02:39:15ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802021-04-0110710.1161/JAHA.120.018905Antiatherosclerotic Phenotype of Perivascular Adipose Tissue Surrounding the Saphenous Vein in Coronary Artery Bypass GraftingTakuma Mikami0Masato Furuhashi1Akiko Sakai2Ryosuke Numaguchi3Ryo Harada4Syuichi Naraoka5Takeshi Kamada6Yukimura Higashiura7Marenao Tanaka8Shunsuke Ohori9Taku Sakurada10Masanori Nakamura11Yutaka Iba12Joji Fukada13Tetsuji Miura14Nobuyoshi Kawaharada15Department of Cardiovascular Surgery Sapporo Medical University School of Medicine Sapporo JapanDepartment of Cardiovascular, Renal and Metabolic Medicine Sapporo Medical University School of Medicine Sapporo JapanDepartment of Cardiovascular, Renal and Metabolic Medicine Sapporo Medical University School of Medicine Sapporo JapanDepartment of Cardiovascular Surgery Sapporo Medical University School of Medicine Sapporo JapanDepartment of Cardiovascular Surgery Sapporo Medical University School of Medicine Sapporo JapanDepartment of Cardiovascular Surgery Sapporo Medical University School of Medicine Sapporo JapanDepartment of Cardiovascular Surgery Sapporo Medical University School of Medicine Sapporo JapanDepartment of Cardiovascular, Renal and Metabolic Medicine Sapporo Medical University School of Medicine Sapporo JapanDepartment of Cardiovascular, Renal and Metabolic Medicine Sapporo Medical University School of Medicine Sapporo JapanDepartment of Cardiovascular Surgery Hokkaido Ohno Memorial Hospital Sapporo JapanDepartment of Cardiovascular Surgery Sapporo Central Hospital Sapporo JapanDepartment of Cardiovascular Surgery Sapporo City General Hospital Sapporo JapanDepartment of Cardiovascular Surgery Teine Keijinkai Hospital Sapporo JapanDepartment of Cardiovascular Surgery Otaru City General Hospital Otaru JapanDepartment of Cardiovascular, Renal and Metabolic Medicine Sapporo Medical University School of Medicine Sapporo JapanDepartment of Cardiovascular Surgery Sapporo Medical University School of Medicine Sapporo JapanBackground Perivascular adipose tissue (PVAT) is associated with metabolically driven chronic inflammation called metaflammation, which contributes to vascular function and the pathogenesis of vascular disease. The saphenous vein (SV) is commonly used as an essential conduit in coronary artery bypass grafting, but the long‐term patency of SV grafts is a crucial issue. The use of the novel “no‐touch” technique of SV harvesting together with its surrounding tissue has been reported to result in good long‑term graft patency of SV grafts. Herein, we investigated whether PVAT surrounding the SV (SV‐PVAT) has distinct phenotypes compared with other PVATs of vessels. Methods and Results Fat pads were sampled from 48 patients (male/female, 32/16; age, 72±8 years) with coronary artery disease who underwent elective coronary artery bypass grafting. Adipocyte size in SV‐PVAT was significantly larger than the sizes in PVATs surrounding the internal thoracic artery, coronary artery, and aorta. SV‐PVAT and PVAT surrounding the internal thoracic artery had smaller extents of fibrosis, decreased gene expression levels of fibrosis‐related markers, and less metaflammation, as indicated by a significantly smaller extent of cluster of differentiation 11c–positive M1 macrophage infiltration, higher gene expression level of adiponectin, and lower gene expression levels of inflammatory cytokines, than did PVATs surrounding the coronary artery and aorta. Expression patterns of adipocyte developmental and pattern‐forming genes were totally different among the PVATs of the vessels. Conclusions The phenotype of SV‐PVAT, which may result from inherent differences in adipocytes, is closer to that of PVAT surrounding the internal thoracic artery than that of PVAT surrounding the coronary artery or that of PVAT surrounding the aorta. SV‐PVAT has less metaflammation and consecutive adipose tissue remodeling, which may contribute to high long‐term patency of grafting when the no‐touch technique of SV harvesting is used.https://www.ahajournals.org/doi/10.1161/JAHA.120.018905coronary artery bypass surgeryepicardial fatperivascular fatsaphenous vein |
| spellingShingle | Takuma Mikami Masato Furuhashi Akiko Sakai Ryosuke Numaguchi Ryo Harada Syuichi Naraoka Takeshi Kamada Yukimura Higashiura Marenao Tanaka Shunsuke Ohori Taku Sakurada Masanori Nakamura Yutaka Iba Joji Fukada Tetsuji Miura Nobuyoshi Kawaharada Antiatherosclerotic Phenotype of Perivascular Adipose Tissue Surrounding the Saphenous Vein in Coronary Artery Bypass Grafting Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease coronary artery bypass surgery epicardial fat perivascular fat saphenous vein |
| title | Antiatherosclerotic Phenotype of Perivascular Adipose Tissue Surrounding the Saphenous Vein in Coronary Artery Bypass Grafting |
| title_full | Antiatherosclerotic Phenotype of Perivascular Adipose Tissue Surrounding the Saphenous Vein in Coronary Artery Bypass Grafting |
| title_fullStr | Antiatherosclerotic Phenotype of Perivascular Adipose Tissue Surrounding the Saphenous Vein in Coronary Artery Bypass Grafting |
| title_full_unstemmed | Antiatherosclerotic Phenotype of Perivascular Adipose Tissue Surrounding the Saphenous Vein in Coronary Artery Bypass Grafting |
| title_short | Antiatherosclerotic Phenotype of Perivascular Adipose Tissue Surrounding the Saphenous Vein in Coronary Artery Bypass Grafting |
| title_sort | antiatherosclerotic phenotype of perivascular adipose tissue surrounding the saphenous vein in coronary artery bypass grafting |
| topic | coronary artery bypass surgery epicardial fat perivascular fat saphenous vein |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.120.018905 |
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