Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions
Abstract Our recent study has shown that prenatal exposure to bisphenol A (BPA) altered the expression of genes associated with autism spectrum disorder (ASD). In this study, we further investigated the effects of prenatal BPA exposure on ASD-related genes known to regulate neuronal viability, neuri...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-80390-2 |
| _version_ | 1818840904298921984 |
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| author | Surangrat Thongkorn Songphon Kanlayaprasit Pawinee Panjabud Thanit Saeliw Thanawin Jantheang Kasidit Kasitipradit Suthathip Sarobol Depicha Jindatip Valerie W. Hu Tewin Tencomnao Takako Kikkawa Tatsuya Sato Noriko Osumi Tewarit Sarachana |
| author_facet | Surangrat Thongkorn Songphon Kanlayaprasit Pawinee Panjabud Thanit Saeliw Thanawin Jantheang Kasidit Kasitipradit Suthathip Sarobol Depicha Jindatip Valerie W. Hu Tewin Tencomnao Takako Kikkawa Tatsuya Sato Noriko Osumi Tewarit Sarachana |
| author_sort | Surangrat Thongkorn |
| collection | DOAJ |
| description | Abstract Our recent study has shown that prenatal exposure to bisphenol A (BPA) altered the expression of genes associated with autism spectrum disorder (ASD). In this study, we further investigated the effects of prenatal BPA exposure on ASD-related genes known to regulate neuronal viability, neuritogenesis, and learning/memory, and assessed these functions in the offspring of exposed pregnant rats. We found that prenatal BPA exposure increased neurite length, the number of primary neurites, and the number of neurite branches, but reduced the size of the hippocampal cell body in both sexes of the offspring. However, in utero exposure to BPA decreased the neuronal viability and the neuronal density in the hippocampus and impaired learning/memory only in the male offspring while the females were not affected. Interestingly, the expression of several ASD-related genes (e.g. Mief2, Eif3h, Cux1, and Atp8a1) in the hippocampus were dysregulated and showed a sex-specific correlation with neuronal viability, neuritogenesis, and/or learning/memory. The findings from this study suggest that prenatal BPA exposure disrupts ASD-related genes involved in neuronal viability, neuritogenesis, and learning/memory in a sex-dependent manner, and these genes may play an important role in the risk and the higher prevalence of ASD in males subjected to prenatal BPA exposure. |
| first_indexed | 2024-12-19T04:17:36Z |
| format | Article |
| id | doaj.art-61335a794d654c10913bb9e06dc44170 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T04:17:36Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-61335a794d654c10913bb9e06dc441702022-12-21T20:36:15ZengNature PortfolioScientific Reports2045-23222021-01-0111111910.1038/s41598-020-80390-2Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functionsSurangrat Thongkorn0Songphon Kanlayaprasit1Pawinee Panjabud2Thanit Saeliw3Thanawin Jantheang4Kasidit Kasitipradit5Suthathip Sarobol6Depicha Jindatip7Valerie W. Hu8Tewin Tencomnao9Takako Kikkawa10Tatsuya Sato11Noriko Osumi12Tewarit Sarachana13The Ph.D. Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn UniversityThe Ph.D. Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn UniversityThe Ph.D. Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn UniversityThe Ph.D. Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn UniversityThe Ph.D. Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn UniversityThe Ph.D. Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn UniversitySpecimen Center, Department of Laboratory Medicine, King Chulalongkorn Memorial HospitalDepartment of Anatomy, Faculty of Medicine, Chulalongkorn UniversityDepartment of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, The George Washington UniversityAge-Related Inflammation and Degeneration Research Unit, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn UniversityDepartment of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of MedicineDepartment of Healthcare Management, Faculty of Health Sciences, Tohoku Fukushi UniversityDepartment of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of MedicineSYstems Neuroscience of Autism and PSychiatric Disorders (SYNAPS) Research Unit, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn UniversityAbstract Our recent study has shown that prenatal exposure to bisphenol A (BPA) altered the expression of genes associated with autism spectrum disorder (ASD). In this study, we further investigated the effects of prenatal BPA exposure on ASD-related genes known to regulate neuronal viability, neuritogenesis, and learning/memory, and assessed these functions in the offspring of exposed pregnant rats. We found that prenatal BPA exposure increased neurite length, the number of primary neurites, and the number of neurite branches, but reduced the size of the hippocampal cell body in both sexes of the offspring. However, in utero exposure to BPA decreased the neuronal viability and the neuronal density in the hippocampus and impaired learning/memory only in the male offspring while the females were not affected. Interestingly, the expression of several ASD-related genes (e.g. Mief2, Eif3h, Cux1, and Atp8a1) in the hippocampus were dysregulated and showed a sex-specific correlation with neuronal viability, neuritogenesis, and/or learning/memory. The findings from this study suggest that prenatal BPA exposure disrupts ASD-related genes involved in neuronal viability, neuritogenesis, and learning/memory in a sex-dependent manner, and these genes may play an important role in the risk and the higher prevalence of ASD in males subjected to prenatal BPA exposure.https://doi.org/10.1038/s41598-020-80390-2 |
| spellingShingle | Surangrat Thongkorn Songphon Kanlayaprasit Pawinee Panjabud Thanit Saeliw Thanawin Jantheang Kasidit Kasitipradit Suthathip Sarobol Depicha Jindatip Valerie W. Hu Tewin Tencomnao Takako Kikkawa Tatsuya Sato Noriko Osumi Tewarit Sarachana Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions Scientific Reports |
| title | Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions |
| title_full | Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions |
| title_fullStr | Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions |
| title_full_unstemmed | Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions |
| title_short | Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions |
| title_sort | sex differences in the effects of prenatal bisphenol a exposure on autism related genes and their relationships with the hippocampus functions |
| url | https://doi.org/10.1038/s41598-020-80390-2 |
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