A new index for the outcome of focal segmental glomerulosclerosis
Abstract Focal segmental glomerulosclerosis (FSGS) is a common pathological form of nephrotic syndrome. This study analyzed the value of pathological lesions and clinical prognosis of different segmental glomerulosclerosis ratios in FSGS. Two hundred and six FSGS patients were collected from Dec 201...
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Nature Portfolio
2024-04-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-59007-5 |
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| author | Liu Chan Yang Danyi Chao Chen |
| author_facet | Liu Chan Yang Danyi Chao Chen |
| author_sort | Liu Chan |
| collection | DOAJ |
| description | Abstract Focal segmental glomerulosclerosis (FSGS) is a common pathological form of nephrotic syndrome. This study analyzed the value of pathological lesions and clinical prognosis of different segmental glomerulosclerosis ratios in FSGS. Two hundred and six FSGS patients were collected from Dec 2013 to Apr 2016. The patients were divided into two groups according to the proportion of glomerular segmental sclerosis: F1 (SSR ≤ 15%, n = 133) and F2 (SSR > 15%, n = 73). The clinical and pathological data were recorded and analyzed, and statistical differences were observed between the serum uric acid level and the percentage of chronic renal failure. The pathological results showed significant differences in interstitial fibrosis and tubular atrophy (IFTA), degree of mesangial hyperplasia, vascular lesions, synaptopodin intensity, and foot process effacement between the two groups. Multivariate logistic regression analysis showed significant differences in creatinine (OR: 1.008) and F2 group (OR: 1.19). In all patients, the prognoses of urine protein and serum creatinine levels were statistically different. Multivariate Cox regression analysis revealed that F2 (hazard ratio: 2.306, 95% CI 1.022–5.207) was associated with a risk of ESRD (end stage renal disease). The proportion of segmental glomerulosclerosis provides a guiding value in the pathological diagnosis and clinical prognosis of FSGS. |
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| language | English |
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| spelling | doaj.art-6133f9a3b7bc44319b68f270294041b42024-05-26T11:16:18ZengNature PortfolioScientific Reports2045-23222024-04-0114111110.1038/s41598-024-59007-5A new index for the outcome of focal segmental glomerulosclerosisLiu Chan0Yang Danyi1Chao Chen2International Medical Department, The Second Xiangya Hospital, Central South UniversityDepartment of Nephrology, The Second Xiangya Hospital, Central South UniversityNational Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South UniversityAbstract Focal segmental glomerulosclerosis (FSGS) is a common pathological form of nephrotic syndrome. This study analyzed the value of pathological lesions and clinical prognosis of different segmental glomerulosclerosis ratios in FSGS. Two hundred and six FSGS patients were collected from Dec 2013 to Apr 2016. The patients were divided into two groups according to the proportion of glomerular segmental sclerosis: F1 (SSR ≤ 15%, n = 133) and F2 (SSR > 15%, n = 73). The clinical and pathological data were recorded and analyzed, and statistical differences were observed between the serum uric acid level and the percentage of chronic renal failure. The pathological results showed significant differences in interstitial fibrosis and tubular atrophy (IFTA), degree of mesangial hyperplasia, vascular lesions, synaptopodin intensity, and foot process effacement between the two groups. Multivariate logistic regression analysis showed significant differences in creatinine (OR: 1.008) and F2 group (OR: 1.19). In all patients, the prognoses of urine protein and serum creatinine levels were statistically different. Multivariate Cox regression analysis revealed that F2 (hazard ratio: 2.306, 95% CI 1.022–5.207) was associated with a risk of ESRD (end stage renal disease). The proportion of segmental glomerulosclerosis provides a guiding value in the pathological diagnosis and clinical prognosis of FSGS.https://doi.org/10.1038/s41598-024-59007-5FSGSSegmental glomerulosclerosisProportionPodocyteOutcome |
| spellingShingle | Liu Chan Yang Danyi Chao Chen A new index for the outcome of focal segmental glomerulosclerosis Scientific Reports FSGS Segmental glomerulosclerosis Proportion Podocyte Outcome |
| title | A new index for the outcome of focal segmental glomerulosclerosis |
| title_full | A new index for the outcome of focal segmental glomerulosclerosis |
| title_fullStr | A new index for the outcome of focal segmental glomerulosclerosis |
| title_full_unstemmed | A new index for the outcome of focal segmental glomerulosclerosis |
| title_short | A new index for the outcome of focal segmental glomerulosclerosis |
| title_sort | new index for the outcome of focal segmental glomerulosclerosis |
| topic | FSGS Segmental glomerulosclerosis Proportion Podocyte Outcome |
| url | https://doi.org/10.1038/s41598-024-59007-5 |
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