Soemmerring’s Rings Developed around IOLs, in Human Donor Eyes, Can Present Internal Transparent Areas
Soemmerring’s rings consist of a ring of lens epithelial derived cells that grow along the periphery of an aphakic lens capsule, or around an intraocular lens. These rings when visualized frontally, appear opaque, however, in some cases the cells that compose these rings are organized in the same fa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/21/13294 |
| _version_ | 1797467916713590784 |
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| author | Justin Christopher D’Antin Francesc Tresserra Rafael I. Barraquer Ralph Michael |
| author_facet | Justin Christopher D’Antin Francesc Tresserra Rafael I. Barraquer Ralph Michael |
| author_sort | Justin Christopher D’Antin |
| collection | DOAJ |
| description | Soemmerring’s rings consist of a ring of lens epithelial derived cells that grow along the periphery of an aphakic lens capsule, or around an intraocular lens. These rings when visualized frontally, appear opaque, however, in some cases the cells that compose these rings are organized in the same fashion as those in normal transparent adult lenses. Thus, our purpose was to test whether any part of the adult Soemmerring’s ring could be transparent and how this related to morphological factors. To study this, 16 Soemmerring’s rings were extracted from donor eye globes. After imaging, they were thickly sectioned sagittally in order to analyze the degrees of transparency of different areas. All samples were also histologically analyzed using alpha smooth muscle actin, Vimentin, wheat germ agglutinin and DAPI. Our results showed that many samples had some transparent areas, mostly towards the center of their cross-section. Of the factors that we analyzed, only lens fiber organization at the bow region and an increased area of mature lens fiber cells had a significant relation to the degree of transparency at the center. Thus, we can conclude that as Soemmerring’s rings mature, they can develop organized and transparent areas of lens cells. |
| first_indexed | 2024-03-09T19:00:33Z |
| format | Article |
| id | doaj.art-6138fdce7576494391582bccbdfe13ac |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T19:00:33Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6138fdce7576494391582bccbdfe13ac2023-11-24T05:05:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123211329410.3390/ijms232113294Soemmerring’s Rings Developed around IOLs, in Human Donor Eyes, Can Present Internal Transparent AreasJustin Christopher D’Antin0Francesc Tresserra1Rafael I. Barraquer2Ralph Michael3Institut Universitari Barraquer, Universitat Autònoma de Barcelona, 08021 Barcelona, SpainDepartment of Pathology, Institut Universitari Dexeus, 08028 Barcelona, SpainInstitut Universitari Barraquer, Universitat Autònoma de Barcelona, 08021 Barcelona, SpainInstitut Universitari Barraquer, Universitat Autònoma de Barcelona, 08021 Barcelona, SpainSoemmerring’s rings consist of a ring of lens epithelial derived cells that grow along the periphery of an aphakic lens capsule, or around an intraocular lens. These rings when visualized frontally, appear opaque, however, in some cases the cells that compose these rings are organized in the same fashion as those in normal transparent adult lenses. Thus, our purpose was to test whether any part of the adult Soemmerring’s ring could be transparent and how this related to morphological factors. To study this, 16 Soemmerring’s rings were extracted from donor eye globes. After imaging, they were thickly sectioned sagittally in order to analyze the degrees of transparency of different areas. All samples were also histologically analyzed using alpha smooth muscle actin, Vimentin, wheat germ agglutinin and DAPI. Our results showed that many samples had some transparent areas, mostly towards the center of their cross-section. Of the factors that we analyzed, only lens fiber organization at the bow region and an increased area of mature lens fiber cells had a significant relation to the degree of transparency at the center. Thus, we can conclude that as Soemmerring’s rings mature, they can develop organized and transparent areas of lens cells.https://www.mdpi.com/1422-0067/23/21/13294Soemmerring’s ringIOLlenstransparencyhistology |
| spellingShingle | Justin Christopher D’Antin Francesc Tresserra Rafael I. Barraquer Ralph Michael Soemmerring’s Rings Developed around IOLs, in Human Donor Eyes, Can Present Internal Transparent Areas International Journal of Molecular Sciences Soemmerring’s ring IOL lens transparency histology |
| title | Soemmerring’s Rings Developed around IOLs, in Human Donor Eyes, Can Present Internal Transparent Areas |
| title_full | Soemmerring’s Rings Developed around IOLs, in Human Donor Eyes, Can Present Internal Transparent Areas |
| title_fullStr | Soemmerring’s Rings Developed around IOLs, in Human Donor Eyes, Can Present Internal Transparent Areas |
| title_full_unstemmed | Soemmerring’s Rings Developed around IOLs, in Human Donor Eyes, Can Present Internal Transparent Areas |
| title_short | Soemmerring’s Rings Developed around IOLs, in Human Donor Eyes, Can Present Internal Transparent Areas |
| title_sort | soemmerring s rings developed around iols in human donor eyes can present internal transparent areas |
| topic | Soemmerring’s ring IOL lens transparency histology |
| url | https://www.mdpi.com/1422-0067/23/21/13294 |
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