Inhibition of Polo-like Kinase 1 Prevents the Male Pronuclear Formation Via Alpha-tubulin Recruiting in In Vivo-fertilized Murine Embryos

Inhibition of Polo-like Kinase 1 Prevents the Male Pronuclear Formation Via Alpha-tubulin Recruiting in In Vivo-fertilized Murine Embryos

Polo-like kinase 1 (Plk1) has been known to be a critical element in cell division including centrosome maturation, cytokinesis and spindle formation in somatic, cancer, and mammalian embryonic cells. In particular, Plk1 is highly expressed in cancer cells. Plk1 inhibitors, such as BI2536, have been...

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Bibliographic Details
Main Authors: Jeonghyeon Moon, Sangho Roh
Format: Article
Language:English
Published: The Korean Society of Animal Reproduction and Biotechnology 2018-12-01
Series:Journal of Animal Reproduction and Biotechnology
Subjects:
polo-like kinase 1 (plk1)
alpha-tubulin (α-tubulin)
bi2536
developmental rate
fertilization
Online Access:http://www.e-jarb.org/journal/view.html?uid=65&vmd=Full

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