<i>Campylobacter</i> Colonization and Diversity in Young Turkeys in the Context of Gastrointestinal Distress and Antimicrobial Treatment
Young turkeys are vulnerable to undifferentiated gastrointestinal distress, including “irritable and crabby syndrome” (ICS), which compromises flock performance and is typically treated with a combination of penicillin and gentamicin (P/G). However, the effects of ICS and P/G treatment on <i>C...
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MDPI AG
2023-01-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/11/2/252 |
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| author | Margaret Kirchner William G. Miller Jason A. Osborne Brian Badgley Jeffrey Neidermeyer Sophia Kathariou |
| author_facet | Margaret Kirchner William G. Miller Jason A. Osborne Brian Badgley Jeffrey Neidermeyer Sophia Kathariou |
| author_sort | Margaret Kirchner |
| collection | DOAJ |
| description | Young turkeys are vulnerable to undifferentiated gastrointestinal distress, including “irritable and crabby syndrome” (ICS), which compromises flock performance and is typically treated with a combination of penicillin and gentamicin (P/G). However, the effects of ICS and P/G treatment on <i>Campylobacter</i> remain poorly understood. We investigated the impact of ICS and P/G treatment on <i>Campylobacter</i> levels and diversity in four flocks from three turkey farms. Cecum and jejunum samples were analyzed weekly from day of hatch to week 4–5. All four flocks became colonized with multidrug resistant (MDR) <i>Campylobacter jejuni</i> and <i>C. coli</i> by week 2–3, and two developed ICS. ICS and P/G treatment did not significantly impact total <i>Campylobacter</i> levels or strain genotypes but impacted species and antimicrobial resistance (AMR) profiles. One flock was raised under antibiotic-free (ABF) conditions while another flock at the same farm was raised conventionally. The ABF flock did not develop ICS while its counterpart did. However, <i>Campylobacter</i> strains, AMR profiles and sequence types were generally shared between these two flocks. Our findings suggest that ICS and P/G treatment impacted <i>Campylobacter</i> population dynamics in commercial young turkey flocks, and that ABF flocks may become readily colonized by MDR strains from non-ABF flocks at the same farm. |
| first_indexed | 2024-03-11T08:24:14Z |
| format | Article |
| id | doaj.art-6139576af83a4581a97a7e2ad1ec8796 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-11T08:24:14Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-6139576af83a4581a97a7e2ad1ec87962023-11-16T22:13:20ZengMDPI AGMicroorganisms2076-26072023-01-0111225210.3390/microorganisms11020252<i>Campylobacter</i> Colonization and Diversity in Young Turkeys in the Context of Gastrointestinal Distress and Antimicrobial TreatmentMargaret Kirchner0William G. Miller1Jason A. Osborne2Brian Badgley3Jeffrey Neidermeyer4Sophia Kathariou5Department of Food, Bioprocessing, and Nutrition Sciences, North Carolina State University, Raleigh, NC 27695, USAProduce Safety and Microbiology Research Unit, Agricultural Research Service, US Department of Agriculture, Albany, CA 94710, USADepartment of Statistics, North Carolina State University, Raleigh, NC 27695, USASchool of Plant and Environmental Sciences, Virginia Tech, Blacksburg, VA 24061, USADepartment of Food, Bioprocessing, and Nutrition Sciences, North Carolina State University, Raleigh, NC 27695, USADepartment of Food, Bioprocessing, and Nutrition Sciences, North Carolina State University, Raleigh, NC 27695, USAYoung turkeys are vulnerable to undifferentiated gastrointestinal distress, including “irritable and crabby syndrome” (ICS), which compromises flock performance and is typically treated with a combination of penicillin and gentamicin (P/G). However, the effects of ICS and P/G treatment on <i>Campylobacter</i> remain poorly understood. We investigated the impact of ICS and P/G treatment on <i>Campylobacter</i> levels and diversity in four flocks from three turkey farms. Cecum and jejunum samples were analyzed weekly from day of hatch to week 4–5. All four flocks became colonized with multidrug resistant (MDR) <i>Campylobacter jejuni</i> and <i>C. coli</i> by week 2–3, and two developed ICS. ICS and P/G treatment did not significantly impact total <i>Campylobacter</i> levels or strain genotypes but impacted species and antimicrobial resistance (AMR) profiles. One flock was raised under antibiotic-free (ABF) conditions while another flock at the same farm was raised conventionally. The ABF flock did not develop ICS while its counterpart did. However, <i>Campylobacter</i> strains, AMR profiles and sequence types were generally shared between these two flocks. Our findings suggest that ICS and P/G treatment impacted <i>Campylobacter</i> population dynamics in commercial young turkey flocks, and that ABF flocks may become readily colonized by MDR strains from non-ABF flocks at the same farm.https://www.mdpi.com/2076-2607/11/2/252turkeys<i>Campylobacter</i>antimicrobial resistancemultidrug resistanceirritable and crabby syndrome |
| spellingShingle | Margaret Kirchner William G. Miller Jason A. Osborne Brian Badgley Jeffrey Neidermeyer Sophia Kathariou <i>Campylobacter</i> Colonization and Diversity in Young Turkeys in the Context of Gastrointestinal Distress and Antimicrobial Treatment Microorganisms turkeys <i>Campylobacter</i> antimicrobial resistance multidrug resistance irritable and crabby syndrome |
| title | <i>Campylobacter</i> Colonization and Diversity in Young Turkeys in the Context of Gastrointestinal Distress and Antimicrobial Treatment |
| title_full | <i>Campylobacter</i> Colonization and Diversity in Young Turkeys in the Context of Gastrointestinal Distress and Antimicrobial Treatment |
| title_fullStr | <i>Campylobacter</i> Colonization and Diversity in Young Turkeys in the Context of Gastrointestinal Distress and Antimicrobial Treatment |
| title_full_unstemmed | <i>Campylobacter</i> Colonization and Diversity in Young Turkeys in the Context of Gastrointestinal Distress and Antimicrobial Treatment |
| title_short | <i>Campylobacter</i> Colonization and Diversity in Young Turkeys in the Context of Gastrointestinal Distress and Antimicrobial Treatment |
| title_sort | i campylobacter i colonization and diversity in young turkeys in the context of gastrointestinal distress and antimicrobial treatment |
| topic | turkeys <i>Campylobacter</i> antimicrobial resistance multidrug resistance irritable and crabby syndrome |
| url | https://www.mdpi.com/2076-2607/11/2/252 |
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