Stem Cell Biomarkers and Tumorigenesis in Gastric Cancer
Stomach cancer has a high mortality, which is partially caused by an absence of suitable biomarkers to allow detection of the initiation stages of cancer progression. Thus, identification of critical biomarkers associated with gastric cancer (GC) is required to advance its clinical diagnoses and tre...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/6/929 |
| _version_ | 1797485554765398016 |
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| author | Kenly Wuputra Chia-Chen Ku Jia-Bin Pan Chung-Jung Liu Yi-Chang Liu Shigeo Saito Kohsuke Kato Ying-Chu Lin Kung-Kai Kuo Te-Fu Chan Inn-Wen Chong Chang-Shen Lin Deng-Chyang Wu Kazunari K. Yokoyama |
| author_facet | Kenly Wuputra Chia-Chen Ku Jia-Bin Pan Chung-Jung Liu Yi-Chang Liu Shigeo Saito Kohsuke Kato Ying-Chu Lin Kung-Kai Kuo Te-Fu Chan Inn-Wen Chong Chang-Shen Lin Deng-Chyang Wu Kazunari K. Yokoyama |
| author_sort | Kenly Wuputra |
| collection | DOAJ |
| description | Stomach cancer has a high mortality, which is partially caused by an absence of suitable biomarkers to allow detection of the initiation stages of cancer progression. Thus, identification of critical biomarkers associated with gastric cancer (GC) is required to advance its clinical diagnoses and treatment. Recent studies using tracing models for lineage analysis of GC stem cells indicate that the cell fate decision of the gastric stem cells might be an important issue for stem cell plasticity. They include leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5<sup>+</sup>), Cholecystokinin receptor 2 (Cckr2<sup>+</sup>), and axis inhibition protein 2 (Axin2<sup>+</sup>) as the stem cell markers in the antrum, Trefoil Factor 2 (TFF2<sup>+</sup>), Mist1<sup>+</sup> stem cells, and Troy+ chief cells in the corpus. By contrast, Estrogen receptor 1 (eR1), Leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1), SRY (sex determining region Y)-box 2 (Sox2), and B lymphoma Mo-MLV insertion region 1 homolog (Bmi1) are rich in both the antrum and corpus regions. These markers might help to identify the cell-lineage identity and analyze the plasticity of each stem cell population. Thus, identification of marker genes for the development of GC and its environment is critical for the clinical application of cancer stem cells in the prevention of stomach cancers. |
| first_indexed | 2024-03-09T23:20:29Z |
| format | Article |
| id | doaj.art-6139d99f03c84018b5506106a014cb7a |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T23:20:29Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-6139d99f03c84018b5506106a014cb7a2023-11-23T17:27:47ZengMDPI AGJournal of Personalized Medicine2075-44262022-06-0112692910.3390/jpm12060929Stem Cell Biomarkers and Tumorigenesis in Gastric CancerKenly Wuputra0Chia-Chen Ku1Jia-Bin Pan2Chung-Jung Liu3Yi-Chang Liu4Shigeo Saito5Kohsuke Kato6Ying-Chu Lin7Kung-Kai Kuo8Te-Fu Chan9Inn-Wen Chong10Chang-Shen Lin11Deng-Chyang Wu12Kazunari K. Yokoyama13Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 80708, TaiwanGraduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 80708, TaiwanGraduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 80708, TaiwanRegenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80708, TaiwanCell Therapy and Research Center, Kaohsiung Medical University Hospital, Kaohsiung 80756, TaiwanSaito Laboratory of Cell Technology, Yaita 329-2192, JapanDepartment of Infection Biology, Graduate School of Comprehensive Human Sciences, The University of Tsukuba, Tsukuba 305-8577, JapanSchool of Dentistry, Kaohsiung Medical University, Kaohsiung 80708, TaiwanRegenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDepartment of Obstetrics and Genecology, Kaohsiung Medical University Hospital, Kaohsiung 80756, TaiwanDivision of Pulmonary and Critical Care Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, TaiwanGraduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 80708, TaiwanRegenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80708, TaiwanGraduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 80708, TaiwanStomach cancer has a high mortality, which is partially caused by an absence of suitable biomarkers to allow detection of the initiation stages of cancer progression. Thus, identification of critical biomarkers associated with gastric cancer (GC) is required to advance its clinical diagnoses and treatment. Recent studies using tracing models for lineage analysis of GC stem cells indicate that the cell fate decision of the gastric stem cells might be an important issue for stem cell plasticity. They include leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5<sup>+</sup>), Cholecystokinin receptor 2 (Cckr2<sup>+</sup>), and axis inhibition protein 2 (Axin2<sup>+</sup>) as the stem cell markers in the antrum, Trefoil Factor 2 (TFF2<sup>+</sup>), Mist1<sup>+</sup> stem cells, and Troy+ chief cells in the corpus. By contrast, Estrogen receptor 1 (eR1), Leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1), SRY (sex determining region Y)-box 2 (Sox2), and B lymphoma Mo-MLV insertion region 1 homolog (Bmi1) are rich in both the antrum and corpus regions. These markers might help to identify the cell-lineage identity and analyze the plasticity of each stem cell population. Thus, identification of marker genes for the development of GC and its environment is critical for the clinical application of cancer stem cells in the prevention of stomach cancers.https://www.mdpi.com/2075-4426/12/6/929biomarkerscancer stem cellsgastric cancersorganoidstranslational research |
| spellingShingle | Kenly Wuputra Chia-Chen Ku Jia-Bin Pan Chung-Jung Liu Yi-Chang Liu Shigeo Saito Kohsuke Kato Ying-Chu Lin Kung-Kai Kuo Te-Fu Chan Inn-Wen Chong Chang-Shen Lin Deng-Chyang Wu Kazunari K. Yokoyama Stem Cell Biomarkers and Tumorigenesis in Gastric Cancer Journal of Personalized Medicine biomarkers cancer stem cells gastric cancers organoids translational research |
| title | Stem Cell Biomarkers and Tumorigenesis in Gastric Cancer |
| title_full | Stem Cell Biomarkers and Tumorigenesis in Gastric Cancer |
| title_fullStr | Stem Cell Biomarkers and Tumorigenesis in Gastric Cancer |
| title_full_unstemmed | Stem Cell Biomarkers and Tumorigenesis in Gastric Cancer |
| title_short | Stem Cell Biomarkers and Tumorigenesis in Gastric Cancer |
| title_sort | stem cell biomarkers and tumorigenesis in gastric cancer |
| topic | biomarkers cancer stem cells gastric cancers organoids translational research |
| url | https://www.mdpi.com/2075-4426/12/6/929 |
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