Comparative Analysis of Patient Satisfaction and Sedation Outcomes in Bronchoscopy: Fentanyl/Chlorpheniramine vs. Ketamine/Chlorpheniramine
This randomized clinical trial aimed to assess and compare patient satisfaction and sedation outcomes in bronchoscopy procedures using two distinct sedation protocols: fentanyl/chlorpheniramine (FC) and ketamine/chlorpheniramine (KC). Ninety patients undergoing simple bronchoscopy and bronchoalveol...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2024-03-01
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| Series: | Acta Medica Iranica |
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| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/11007 |
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| author | Mohammadreza Khajavi Leila Sadat Hosseini Marzieh Pazoki Seyed Hamidreza Sharifnia Reza Shariat Moharari Pejman Pourfakhr Parisa Kianpour Abbas Ostadalipour Atabak Najafi Farhad Etezadi |
| author_facet | Mohammadreza Khajavi Leila Sadat Hosseini Marzieh Pazoki Seyed Hamidreza Sharifnia Reza Shariat Moharari Pejman Pourfakhr Parisa Kianpour Abbas Ostadalipour Atabak Najafi Farhad Etezadi |
| author_sort | Mohammadreza Khajavi |
| collection | DOAJ |
| description |
This randomized clinical trial aimed to assess and compare patient satisfaction and sedation outcomes in bronchoscopy procedures using two distinct sedation protocols: fentanyl/chlorpheniramine (FC) and ketamine/chlorpheniramine (KC). Ninety patients undergoing simple bronchoscopy and bronchoalveolar lavage were randomly assigned to receive either FC (1 µg/kg fentanyl and 10 mg chlorpheniramine) or KC (0.5 mg/kg ketamine and 10 mg chlorpheniramine). Lidocaine was also administered during bronchoscopy. Primary outcomes included patient satisfaction scores, while secondary outcomes encompassed sedation levels, bronchoscopist satisfaction, cough rates, lidocaine usage, and physiological parameters. Patients in the FC group exhibited significantly higher satisfaction levels compared to the KC group (P=0.002). Bronchoscopist satisfaction was also superior in the FC group (P=0.001). Although cough rates did not differ significantly, severe persistent coughs were more prevalent in the KC group. Physiological parameters such as oxygen saturation were comparable, but the KC group demonstrated higher increases in systolic blood pressure and heart rate. The use of fentanyl/chlorpheniramine resulted in higher patient and bronchoscopist satisfaction during simple bronchoscopy and bronchoalveolar lavage compared to ketamine/chlorpheniramine. This study suggests that the combination of fentanyl and chlorpheniramine may be a preferable sedation choice for bronchoscopy procedures.
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| first_indexed | 2024-04-24T12:29:37Z |
| format | Article |
| id | doaj.art-613ad70a7b04426cb15928e8e28b6dd2 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-04-24T12:29:37Z |
| publishDate | 2024-03-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-613ad70a7b04426cb15928e8e28b6dd22024-04-08T06:25:21ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942024-03-0161910.18502/acta.v61i9.15281Comparative Analysis of Patient Satisfaction and Sedation Outcomes in Bronchoscopy: Fentanyl/Chlorpheniramine vs. Ketamine/ChlorpheniramineMohammadreza Khajavi0Leila Sadat Hosseini1Marzieh Pazoki2Seyed Hamidreza Sharifnia3Reza Shariat Moharari4Pejman Pourfakhr5Parisa Kianpour6Abbas Ostadalipour7Atabak Najafi8Farhad Etezadi9Anesthesia, Critical Care and Pain Management Research Center, Tehran University of Medical Sciences, Tehran, Iran.Department of Anesthesiology and Critical Care, Sina Hospital, Tehran University of Medical Sciences, Tehran, IranDepartment of Internal Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, IranAnesthesia, Critical Care and Pain Management Research Center, Tehran University of Medical Sciences, Tehran, IranAnesthesia, Critical Care and Pain Management Research Center, Tehran University of Medical Sciences, Tehran, Irantehran university of medical sciencesAnesthesia, Critical Care and Pain Management Research Center, Tehran University of Medical Sciences, Tehran, IranAnesthesia, Critical Care and Pain Management Research Center, Tehran University of Medical Sciences, Tehran, IranAnesthesia, Critical Care and Pain Management Research Center, Tehran University of Medical Sciences, Tehran, IranAnesthesia, Critical Care and Pain Management Research Center, Tehran University of Medical Sciences, Tehran, Iran This randomized clinical trial aimed to assess and compare patient satisfaction and sedation outcomes in bronchoscopy procedures using two distinct sedation protocols: fentanyl/chlorpheniramine (FC) and ketamine/chlorpheniramine (KC). Ninety patients undergoing simple bronchoscopy and bronchoalveolar lavage were randomly assigned to receive either FC (1 µg/kg fentanyl and 10 mg chlorpheniramine) or KC (0.5 mg/kg ketamine and 10 mg chlorpheniramine). Lidocaine was also administered during bronchoscopy. Primary outcomes included patient satisfaction scores, while secondary outcomes encompassed sedation levels, bronchoscopist satisfaction, cough rates, lidocaine usage, and physiological parameters. Patients in the FC group exhibited significantly higher satisfaction levels compared to the KC group (P=0.002). Bronchoscopist satisfaction was also superior in the FC group (P=0.001). Although cough rates did not differ significantly, severe persistent coughs were more prevalent in the KC group. Physiological parameters such as oxygen saturation were comparable, but the KC group demonstrated higher increases in systolic blood pressure and heart rate. The use of fentanyl/chlorpheniramine resulted in higher patient and bronchoscopist satisfaction during simple bronchoscopy and bronchoalveolar lavage compared to ketamine/chlorpheniramine. This study suggests that the combination of fentanyl and chlorpheniramine may be a preferable sedation choice for bronchoscopy procedures. https://acta.tums.ac.ir/index.php/acta/article/view/11007BronchoscopyFentanylKetamineChlorpheniramineSedationPatient satisfaction |
| spellingShingle | Mohammadreza Khajavi Leila Sadat Hosseini Marzieh Pazoki Seyed Hamidreza Sharifnia Reza Shariat Moharari Pejman Pourfakhr Parisa Kianpour Abbas Ostadalipour Atabak Najafi Farhad Etezadi Comparative Analysis of Patient Satisfaction and Sedation Outcomes in Bronchoscopy: Fentanyl/Chlorpheniramine vs. Ketamine/Chlorpheniramine Acta Medica Iranica Bronchoscopy Fentanyl Ketamine Chlorpheniramine Sedation Patient satisfaction |
| title | Comparative Analysis of Patient Satisfaction and Sedation Outcomes in Bronchoscopy: Fentanyl/Chlorpheniramine vs. Ketamine/Chlorpheniramine |
| title_full | Comparative Analysis of Patient Satisfaction and Sedation Outcomes in Bronchoscopy: Fentanyl/Chlorpheniramine vs. Ketamine/Chlorpheniramine |
| title_fullStr | Comparative Analysis of Patient Satisfaction and Sedation Outcomes in Bronchoscopy: Fentanyl/Chlorpheniramine vs. Ketamine/Chlorpheniramine |
| title_full_unstemmed | Comparative Analysis of Patient Satisfaction and Sedation Outcomes in Bronchoscopy: Fentanyl/Chlorpheniramine vs. Ketamine/Chlorpheniramine |
| title_short | Comparative Analysis of Patient Satisfaction and Sedation Outcomes in Bronchoscopy: Fentanyl/Chlorpheniramine vs. Ketamine/Chlorpheniramine |
| title_sort | comparative analysis of patient satisfaction and sedation outcomes in bronchoscopy fentanyl chlorpheniramine vs ketamine chlorpheniramine |
| topic | Bronchoscopy Fentanyl Ketamine Chlorpheniramine Sedation Patient satisfaction |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/11007 |
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