Role of Postoperative Radiotherapy for Stage I/II/III Thymic Tumor - Results of the ChART Retrospective Database
Background and objective Postoperative radiotherapy (PORT) for thymic tumor is still controversial. The object of the study is to evaluate the role of PORT for stage I/II/III thymic tumor. Methods The database of Chinese Alliance of Research for Thymomas (ChART) was retrieved for patients with stage...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2016-07-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2016.07.09 |
| _version_ | 1819241015325753344 |
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| author | Qianwen LIU Zhitao GU Fu YANG Jianhua FU Yi SHEN Yucheng WEI Lijie TAN Peng ZHANG Yongtao HAN Chun CHEN Renquan ZHANG Yin LI Ke-Neng CHEN Hezhong CHEN Yongyu LIU Youbing CUI Yun WANG Liewen PANG Zhentao YU Xinming ZHOU Yangchun LIU Jin XIANG Yuan LIU Wentao FANG Members of the Chinese Alliance for Research in Thymomas |
| author_facet | Qianwen LIU Zhitao GU Fu YANG Jianhua FU Yi SHEN Yucheng WEI Lijie TAN Peng ZHANG Yongtao HAN Chun CHEN Renquan ZHANG Yin LI Ke-Neng CHEN Hezhong CHEN Yongyu LIU Youbing CUI Yun WANG Liewen PANG Zhentao YU Xinming ZHOU Yangchun LIU Jin XIANG Yuan LIU Wentao FANG Members of the Chinese Alliance for Research in Thymomas |
| author_sort | Qianwen LIU |
| collection | DOAJ |
| description | Background and objective Postoperative radiotherapy (PORT) for thymic tumor is still controversial. The object of the study is to evaluate the role of PORT for stage I/II/III thymic tumor. Methods The database of Chinese Alliance of Research for Thymomas (ChART) was retrieved for patients with stage I/II/III thymic tumor who underwent surgical therapy without neoajuvant therapy between 1994 and 2012. Univariate and multivariate survival analyses were performed. Cox proportional hazard model was used to determine the hazard ratio for death. Results 1,546 stage I/II/III patients were identified from ChART database. Among these patients, 649 (41.98%) underwent PORT. PORT was associated with gender, histologic type (World Health Organization, WHO), surgical extent, complete resection, Masaoka stage and adjuvant chemotherapy. The 5-yr and 10-yr overall survival (OS) rates and disease-free survival (DFS) rate for patients underwent surgery followed by PORT were 90% and 80%, 81% and 63%, comparing with 96% and 95%, 92% and 90% for patients underwent surgery alone (P=0.001, P<0.001) respectively. In univariate analysis, age, histologic type (WHO), Masaoka stage, completeness of resection, and PORT were associated with OS. Multivariable analysis showed that histologic type (WHO)(P=0.001), Masaoka stage (P=0.029) and completeness of resection (P=0.003) were independently prognostic factors of OS. In univariate analysis, gender, myasthenia gravis, histologic type (WHO), Masaoka stage, surgical approach, PORT and completeness of resection were associated with DFS. Multivariable analysis showed that histologic type (WHO) (P<0.001), Masaoka stage (P=0.005) and completeness of resection (P=0.006) were independently prognostic factors of DFS. Subgroup analysis showed that patients with incomplete resection underwent PORT achieved the better OS and DFS (P=0.010, 0.017, respectively). However, patients with complete resection underwent PORT had the worse OS and DFS (P<0.001, P<0.001, respectively). Conclusion The current retrospective study indicated that PORT after incomplete resection could improve OS and DFS for patients with stage I/II/III thymic tumor. But for those after complete resection, PORT may not help improve prognosis on the whole. |
| first_indexed | 2024-12-23T14:17:11Z |
| format | Article |
| id | doaj.art-613b1fe58aff42589f0208233b5a6998 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-23T14:17:11Z |
| publishDate | 2016-07-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-613b1fe58aff42589f0208233b5a69982022-12-21T17:43:54ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872016-07-0119746547210.3779/j.issn.1009-3419.2016.07.09Role of Postoperative Radiotherapy for Stage I/II/III Thymic Tumor - Results of the ChART Retrospective DatabaseQianwen LIU0Zhitao GU1Fu YANG2Jianhua FU3Yi SHEN4Yucheng WEI5Lijie TAN6Peng ZHANG7Yongtao HAN8Chun CHEN9Renquan ZHANG10Yin LI11Ke-Neng CHEN12Hezhong CHEN13Yongyu LIU14Youbing CUI15Yun WANG16Liewen PANG17Zhentao YU18Xinming ZHOU19Yangchun LIU20Jin XIANG21Yuan LIU22Wentao FANG23Members of the Chinese Alliance for Research in ThymomasDepartment of Thoracic Surgery, Guangdong Esophageal Cancer Institute, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, ChinaDepartment of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, ChinaDepartment of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, ChinaDepartment of Thoracic Surgery, Guangdong Esophageal Cancer Institute, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, ChinaDepartment of Thoracic Surgery, Affiliated Hospital of Qingdao University, Qingdao 266001, ChinaDepartment of Thoracic Surgery, Affiliated Hospital of Qingdao University, Qingdao 266001, ChinaDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Endocrinology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Thoracic Surgery, Sichuan Cancer Hospital, Chengdu 610041, ChinaDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, ChinaDepartment of Thoracic Surgery, First Affiliated Hospital of Anhui Medical University, Hefei 230022, ChinaDepartment of Thoracic Surgery, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, ChinaDepartment of Thoracic Surgery, Beijing Cancer Hospital, Beijing 100142, ChinaDepartment of Cardiothoracic Surgery, Changhai Hospital, Shanghai 200433, ChinaDepartment of Thoracic Surgery, Liaoning Cancer Hospital, Shenyang 110042, ChinaDepartment of Thoracic Surgery, First Affiliated Hospital of Jilin University, Changchun 130021, ChinaDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of General Surgery, Huashan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Esophageal Cancer, Tianjin Cancer Hospital, Tianjin 300060, ChinaDepartment of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, ChinaDepartment of Thoracic Surgery, Jiangxi People’s Hospital, Nanchang 330006, ChinaDepartment of Pathology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, ChinaDepartment of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, ChinaDepartment of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, ChinaBackground and objective Postoperative radiotherapy (PORT) for thymic tumor is still controversial. The object of the study is to evaluate the role of PORT for stage I/II/III thymic tumor. Methods The database of Chinese Alliance of Research for Thymomas (ChART) was retrieved for patients with stage I/II/III thymic tumor who underwent surgical therapy without neoajuvant therapy between 1994 and 2012. Univariate and multivariate survival analyses were performed. Cox proportional hazard model was used to determine the hazard ratio for death. Results 1,546 stage I/II/III patients were identified from ChART database. Among these patients, 649 (41.98%) underwent PORT. PORT was associated with gender, histologic type (World Health Organization, WHO), surgical extent, complete resection, Masaoka stage and adjuvant chemotherapy. The 5-yr and 10-yr overall survival (OS) rates and disease-free survival (DFS) rate for patients underwent surgery followed by PORT were 90% and 80%, 81% and 63%, comparing with 96% and 95%, 92% and 90% for patients underwent surgery alone (P=0.001, P<0.001) respectively. In univariate analysis, age, histologic type (WHO), Masaoka stage, completeness of resection, and PORT were associated with OS. Multivariable analysis showed that histologic type (WHO)(P=0.001), Masaoka stage (P=0.029) and completeness of resection (P=0.003) were independently prognostic factors of OS. In univariate analysis, gender, myasthenia gravis, histologic type (WHO), Masaoka stage, surgical approach, PORT and completeness of resection were associated with DFS. Multivariable analysis showed that histologic type (WHO) (P<0.001), Masaoka stage (P=0.005) and completeness of resection (P=0.006) were independently prognostic factors of DFS. Subgroup analysis showed that patients with incomplete resection underwent PORT achieved the better OS and DFS (P=0.010, 0.017, respectively). However, patients with complete resection underwent PORT had the worse OS and DFS (P<0.001, P<0.001, respectively). Conclusion The current retrospective study indicated that PORT after incomplete resection could improve OS and DFS for patients with stage I/II/III thymic tumor. But for those after complete resection, PORT may not help improve prognosis on the whole.http://dx.doi.org/10.3779/j.issn.1009-3419.2016.07.09Thymic tumorPostoperative radiotherapyOverall survival |
| spellingShingle | Qianwen LIU Zhitao GU Fu YANG Jianhua FU Yi SHEN Yucheng WEI Lijie TAN Peng ZHANG Yongtao HAN Chun CHEN Renquan ZHANG Yin LI Ke-Neng CHEN Hezhong CHEN Yongyu LIU Youbing CUI Yun WANG Liewen PANG Zhentao YU Xinming ZHOU Yangchun LIU Jin XIANG Yuan LIU Wentao FANG Members of the Chinese Alliance for Research in Thymomas Role of Postoperative Radiotherapy for Stage I/II/III Thymic Tumor - Results of the ChART Retrospective Database Chinese Journal of Lung Cancer Thymic tumor Postoperative radiotherapy Overall survival |
| title | Role of Postoperative Radiotherapy for Stage I/II/III Thymic Tumor - Results of the ChART Retrospective Database |
| title_full | Role of Postoperative Radiotherapy for Stage I/II/III Thymic Tumor - Results of the ChART Retrospective Database |
| title_fullStr | Role of Postoperative Radiotherapy for Stage I/II/III Thymic Tumor - Results of the ChART Retrospective Database |
| title_full_unstemmed | Role of Postoperative Radiotherapy for Stage I/II/III Thymic Tumor - Results of the ChART Retrospective Database |
| title_short | Role of Postoperative Radiotherapy for Stage I/II/III Thymic Tumor - Results of the ChART Retrospective Database |
| title_sort | role of postoperative radiotherapy for stage i ii iii thymic tumor results of the chart retrospective database |
| topic | Thymic tumor Postoperative radiotherapy Overall survival |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2016.07.09 |
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