Biomarkers for biosensors to monitor space-induced cardiovascular ageing
Human presence in space has uncovered several health concerns related to the space environment that need to be addressed for future space missions. The hostile space environment includes radiation and microgravity that cause various pathophysiological effects. Among them are conditions related to th...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-02-01
|
| Series: | Frontiers in Sensors |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fsens.2023.1015403/full |
| _version_ | 1811173159515193344 |
|---|---|
| author | Emil Rehnberg Emil Rehnberg Katrijn Quaghebeur Katrijn Quaghebeur Bjorn Baselet Nicholas Rajan Tarek Shazly Lorenzo Moroni Sarah Baatout Sarah Baatout Sarah Baatout Kevin Tabury Kevin Tabury |
| author_facet | Emil Rehnberg Emil Rehnberg Katrijn Quaghebeur Katrijn Quaghebeur Bjorn Baselet Nicholas Rajan Tarek Shazly Lorenzo Moroni Sarah Baatout Sarah Baatout Sarah Baatout Kevin Tabury Kevin Tabury |
| author_sort | Emil Rehnberg |
| collection | DOAJ |
| description | Human presence in space has uncovered several health concerns related to the space environment that need to be addressed for future space missions. The hostile space environment includes radiation and microgravity that cause various pathophysiological effects. Among them are conditions related to the cardiovascular system. The cardiovascular system shows a dysfunctional and deconditioning state, similar to ageing on Earth, once exposed to the space environment. As we aim for longer space missions to the Moon, Mars, and thus into deep space, better understanding, monitoring, and development of countermeasures for these accelerated ageing processes are necessary. Biomarkers and their integration into biosensors therefore become important tools to understand the underlying mechanisms, develop countermeasures and monitor accelerated cardiovascular ageing. In this review, we will provide a brief overview of the space environment and its effects on the human cardiovascular system. We list the known potential cardiovascular ageing biomarkers relevant to space along with our current knowledge of the underlying mechanisms of cardiovascular ageing. We also explore in more details about the various biosensors used, their specifications, and how lab-on-a-chip systems are crucial to the development of these biosensors for tracking cardiovascular ageing during upcoming space missions. |
| first_indexed | 2024-04-10T17:42:08Z |
| format | Article |
| id | doaj.art-613b27cd71b84e3c981771185e891458 |
| institution | Directory Open Access Journal |
| issn | 2673-5067 |
| language | English |
| last_indexed | 2024-04-10T17:42:08Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Sensors |
| spelling | doaj.art-613b27cd71b84e3c981771185e8914582023-02-03T10:24:11ZengFrontiers Media S.A.Frontiers in Sensors2673-50672023-02-01410.3389/fsens.2023.10154031015403Biomarkers for biosensors to monitor space-induced cardiovascular ageingEmil Rehnberg0Emil Rehnberg1Katrijn Quaghebeur2Katrijn Quaghebeur3Bjorn Baselet4Nicholas Rajan5Tarek Shazly6Lorenzo Moroni7Sarah Baatout8Sarah Baatout9Sarah Baatout10Kevin Tabury11Kevin Tabury12Radiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), Mol, BelgiumDepartment of Molecular Biotechnology, Ghent University, Ghent, BelgiumRadiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), Mol, BelgiumDepartment of Physics and Astronomy, Faculty of Sciences, KU Leuven, Leuven, BelgiumRadiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), Mol, BelgiumRadiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), Mol, BelgiumDepartment of Biomedical Engineering, College of Engineering and Computing, University of South Carolina, Columbia, SC, United StatesDepartment of Complex Tissue Regeneration, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, NetherlandsRadiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), Mol, BelgiumDepartment of Molecular Biotechnology, Ghent University, Ghent, BelgiumDepartment of Physics and Astronomy, Faculty of Sciences, KU Leuven, Leuven, BelgiumRadiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), Mol, BelgiumDepartment of Biomedical Engineering, College of Engineering and Computing, University of South Carolina, Columbia, SC, United StatesHuman presence in space has uncovered several health concerns related to the space environment that need to be addressed for future space missions. The hostile space environment includes radiation and microgravity that cause various pathophysiological effects. Among them are conditions related to the cardiovascular system. The cardiovascular system shows a dysfunctional and deconditioning state, similar to ageing on Earth, once exposed to the space environment. As we aim for longer space missions to the Moon, Mars, and thus into deep space, better understanding, monitoring, and development of countermeasures for these accelerated ageing processes are necessary. Biomarkers and their integration into biosensors therefore become important tools to understand the underlying mechanisms, develop countermeasures and monitor accelerated cardiovascular ageing. In this review, we will provide a brief overview of the space environment and its effects on the human cardiovascular system. We list the known potential cardiovascular ageing biomarkers relevant to space along with our current knowledge of the underlying mechanisms of cardiovascular ageing. We also explore in more details about the various biosensors used, their specifications, and how lab-on-a-chip systems are crucial to the development of these biosensors for tracking cardiovascular ageing during upcoming space missions.https://www.frontiersin.org/articles/10.3389/fsens.2023.1015403/fullbiosensorsspace explorationbiomarkerslab-on-chipcardiovascular ageing |
| spellingShingle | Emil Rehnberg Emil Rehnberg Katrijn Quaghebeur Katrijn Quaghebeur Bjorn Baselet Nicholas Rajan Tarek Shazly Lorenzo Moroni Sarah Baatout Sarah Baatout Sarah Baatout Kevin Tabury Kevin Tabury Biomarkers for biosensors to monitor space-induced cardiovascular ageing Frontiers in Sensors biosensors space exploration biomarkers lab-on-chip cardiovascular ageing |
| title | Biomarkers for biosensors to monitor space-induced cardiovascular ageing |
| title_full | Biomarkers for biosensors to monitor space-induced cardiovascular ageing |
| title_fullStr | Biomarkers for biosensors to monitor space-induced cardiovascular ageing |
| title_full_unstemmed | Biomarkers for biosensors to monitor space-induced cardiovascular ageing |
| title_short | Biomarkers for biosensors to monitor space-induced cardiovascular ageing |
| title_sort | biomarkers for biosensors to monitor space induced cardiovascular ageing |
| topic | biosensors space exploration biomarkers lab-on-chip cardiovascular ageing |
| url | https://www.frontiersin.org/articles/10.3389/fsens.2023.1015403/full |
| work_keys_str_mv | AT emilrehnberg biomarkersforbiosensorstomonitorspaceinducedcardiovascularageing AT emilrehnberg biomarkersforbiosensorstomonitorspaceinducedcardiovascularageing AT katrijnquaghebeur biomarkersforbiosensorstomonitorspaceinducedcardiovascularageing AT katrijnquaghebeur biomarkersforbiosensorstomonitorspaceinducedcardiovascularageing AT bjornbaselet biomarkersforbiosensorstomonitorspaceinducedcardiovascularageing AT nicholasrajan biomarkersforbiosensorstomonitorspaceinducedcardiovascularageing AT tarekshazly biomarkersforbiosensorstomonitorspaceinducedcardiovascularageing AT lorenzomoroni biomarkersforbiosensorstomonitorspaceinducedcardiovascularageing AT sarahbaatout biomarkersforbiosensorstomonitorspaceinducedcardiovascularageing AT sarahbaatout biomarkersforbiosensorstomonitorspaceinducedcardiovascularageing AT sarahbaatout biomarkersforbiosensorstomonitorspaceinducedcardiovascularageing AT kevintabury biomarkersforbiosensorstomonitorspaceinducedcardiovascularageing AT kevintabury biomarkersforbiosensorstomonitorspaceinducedcardiovascularageing |