Patterns and predictors of analgesic use in pregnancy: a longitudinal drug utilization study with special focus on women with migraine
Abstract Background Few studies have investigated the drug utilization patterns and factors predicting drug use in pregnant women with migraine. This longitudinal drug utilization study aimed to describe patterns of analgesic use in a sample of Norwegian pregnant women according to their migraine hi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-07-01
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| Series: | BMC Pregnancy and Childbirth |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12884-017-1399-0 |
| _version_ | 1818940980968030208 |
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| author | Gerd-Marie Eskerud Harris Mollie Wood Malin Eberhard-Gran Christofer Lundqvist Hedvig Nordeng |
| author_facet | Gerd-Marie Eskerud Harris Mollie Wood Malin Eberhard-Gran Christofer Lundqvist Hedvig Nordeng |
| author_sort | Gerd-Marie Eskerud Harris |
| collection | DOAJ |
| description | Abstract Background Few studies have investigated the drug utilization patterns and factors predicting drug use in pregnant women with migraine. This longitudinal drug utilization study aimed to describe patterns of analgesic use in a sample of Norwegian pregnant women according to their migraine history, and to identify predictors for analgesic use among these women. Methods Pregnant women giving birth at Akershus University Hospital between 2008 and 2010 were recruited at ultrasound examination in gestational week 17. Data were collected by questionnaires in gestational weeks 17 and 32, and at 8 weeks postpartum, and linked to birth records. Women were grouped into four categories according to migraine history: no migraine history, previous migraine history, recent migraine history (within 1 year prior to pregnancy) and migraine in pregnancy. Patterns of use of analgesics were analyzed descriptively. Multivariable logistic regression was used to identify factors predicting analgesic use. Results Out of 1981 women, 5.0% reported having migraine in pregnancy, 13.2% had a recent history of migraine, 11.5% had a previous history of migraine, and 68.8% reported no history of migraine. Analgesic use declined during pregnancy. Many women switched from triptans and non-steroidal anti-inflammatory drugs to paracetamol, which constituted most of the analgesic use. Factors associated with analgesic use included recent migraine history (OR 1.6, 95% CI 1.2–2.2), more severe headache intensity (OR 1.3, 95% CI 1.3–1.4), smoking (OR 1.9, 95% CI 1.1–3.3) and multiparity (OR 1.4, 95% CI 1.1–1.7). Conclusions Women with migraine stop or switch medications during pregnancy. Analgesic use in pregnancy is affected by migraine characteristics and intensity, and also by socio-demographic factors. Clinicians should bear this in mind when giving advice on adequate management of migraine in pregnancy and safe analgesic use. |
| first_indexed | 2024-12-20T06:48:16Z |
| format | Article |
| id | doaj.art-613c2500a65a47f0821bf0f6dd336f04 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-12-20T06:48:16Z |
| publishDate | 2017-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-613c2500a65a47f0821bf0f6dd336f042022-12-21T19:49:38ZengBMCBMC Pregnancy and Childbirth1471-23932017-07-0117111110.1186/s12884-017-1399-0Patterns and predictors of analgesic use in pregnancy: a longitudinal drug utilization study with special focus on women with migraineGerd-Marie Eskerud Harris0Mollie Wood1Malin Eberhard-Gran2Christofer Lundqvist3Hedvig Nordeng4Pharmacoepidemiology & Drug Safety Research Group, School of Pharmacy, Faculty of Mathematics and Natural Sciences, University of OsloPharmacoepidemiology & Drug Safety Research Group, School of Pharmacy, Faculty of Mathematics and Natural Sciences, University of OsloDepartment of Child Health, National Institute of Public HealthHealth Services Research, Research Department, Akershus University Hospital and University of OsloPharmacoepidemiology & Drug Safety Research Group, School of Pharmacy, Faculty of Mathematics and Natural Sciences, University of OsloAbstract Background Few studies have investigated the drug utilization patterns and factors predicting drug use in pregnant women with migraine. This longitudinal drug utilization study aimed to describe patterns of analgesic use in a sample of Norwegian pregnant women according to their migraine history, and to identify predictors for analgesic use among these women. Methods Pregnant women giving birth at Akershus University Hospital between 2008 and 2010 were recruited at ultrasound examination in gestational week 17. Data were collected by questionnaires in gestational weeks 17 and 32, and at 8 weeks postpartum, and linked to birth records. Women were grouped into four categories according to migraine history: no migraine history, previous migraine history, recent migraine history (within 1 year prior to pregnancy) and migraine in pregnancy. Patterns of use of analgesics were analyzed descriptively. Multivariable logistic regression was used to identify factors predicting analgesic use. Results Out of 1981 women, 5.0% reported having migraine in pregnancy, 13.2% had a recent history of migraine, 11.5% had a previous history of migraine, and 68.8% reported no history of migraine. Analgesic use declined during pregnancy. Many women switched from triptans and non-steroidal anti-inflammatory drugs to paracetamol, which constituted most of the analgesic use. Factors associated with analgesic use included recent migraine history (OR 1.6, 95% CI 1.2–2.2), more severe headache intensity (OR 1.3, 95% CI 1.3–1.4), smoking (OR 1.9, 95% CI 1.1–3.3) and multiparity (OR 1.4, 95% CI 1.1–1.7). Conclusions Women with migraine stop or switch medications during pregnancy. Analgesic use in pregnancy is affected by migraine characteristics and intensity, and also by socio-demographic factors. Clinicians should bear this in mind when giving advice on adequate management of migraine in pregnancy and safe analgesic use.http://link.springer.com/article/10.1186/s12884-017-1399-0PregnancyDrug utilizationMigraineAnalgesicsPredictors |
| spellingShingle | Gerd-Marie Eskerud Harris Mollie Wood Malin Eberhard-Gran Christofer Lundqvist Hedvig Nordeng Patterns and predictors of analgesic use in pregnancy: a longitudinal drug utilization study with special focus on women with migraine BMC Pregnancy and Childbirth Pregnancy Drug utilization Migraine Analgesics Predictors |
| title | Patterns and predictors of analgesic use in pregnancy: a longitudinal drug utilization study with special focus on women with migraine |
| title_full | Patterns and predictors of analgesic use in pregnancy: a longitudinal drug utilization study with special focus on women with migraine |
| title_fullStr | Patterns and predictors of analgesic use in pregnancy: a longitudinal drug utilization study with special focus on women with migraine |
| title_full_unstemmed | Patterns and predictors of analgesic use in pregnancy: a longitudinal drug utilization study with special focus on women with migraine |
| title_short | Patterns and predictors of analgesic use in pregnancy: a longitudinal drug utilization study with special focus on women with migraine |
| title_sort | patterns and predictors of analgesic use in pregnancy a longitudinal drug utilization study with special focus on women with migraine |
| topic | Pregnancy Drug utilization Migraine Analgesics Predictors |
| url | http://link.springer.com/article/10.1186/s12884-017-1399-0 |
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