Circular RNA as a Novel Biomarker and Therapeutic Target for HCC
Circular RNA (circRNA) is a kind of endogenous non-coding RNA (ncRNA), which is produced by the reverse splicing of precursor mRNA (pre mRNA). It is widely expressed in a variety of biological cells. Due to the special formation mode, circRNA does not have a 5′ terminal cap and 3′ poly (A) tail stru...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/12/1948 |
| _version_ | 1797488914731106304 |
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| author | Hongwu Meng Ruowen Niu Cheng Huang Jun Li |
| author_facet | Hongwu Meng Ruowen Niu Cheng Huang Jun Li |
| author_sort | Hongwu Meng |
| collection | DOAJ |
| description | Circular RNA (circRNA) is a kind of endogenous non-coding RNA (ncRNA), which is produced by the reverse splicing of precursor mRNA (pre mRNA). It is widely expressed in a variety of biological cells. Due to the special formation mode, circRNA does not have a 5′ terminal cap and 3′ poly (A) tail structure. Compared with linear RNA, circRNA is more stable to exonuclease and ribonuclease. In addition, circRNA is structurally conserved, has a stable sequence and is tissue-specific. With the development of high-throughput sequencing and bioinformatics technology, more and more circRNAs have been found. CircRNA plays an important pathophysiological role in the occurrence and development of alcoholic liver injury (ALI), hepatic fibrosis (HF), hepatocellular carcinoma (HCC), and other liver diseases. Our group has been committed to the research of liver disease diagnosis and treatment targets. We review the function and mechanism of circRNA in ALI, HF and HCC, expecting to provide new ideas for the diagnosis, treatment, and prognosis of liver diseases. |
| first_indexed | 2024-03-10T00:10:04Z |
| format | Article |
| id | doaj.art-613d8980af59474798979d5e5ff2631f |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T00:10:04Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-613d8980af59474798979d5e5ff2631f2023-11-23T16:02:00ZengMDPI AGCells2073-44092022-06-011112194810.3390/cells11121948Circular RNA as a Novel Biomarker and Therapeutic Target for HCCHongwu Meng0Ruowen Niu1Cheng Huang2Jun Li3Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, ChinaCircular RNA (circRNA) is a kind of endogenous non-coding RNA (ncRNA), which is produced by the reverse splicing of precursor mRNA (pre mRNA). It is widely expressed in a variety of biological cells. Due to the special formation mode, circRNA does not have a 5′ terminal cap and 3′ poly (A) tail structure. Compared with linear RNA, circRNA is more stable to exonuclease and ribonuclease. In addition, circRNA is structurally conserved, has a stable sequence and is tissue-specific. With the development of high-throughput sequencing and bioinformatics technology, more and more circRNAs have been found. CircRNA plays an important pathophysiological role in the occurrence and development of alcoholic liver injury (ALI), hepatic fibrosis (HF), hepatocellular carcinoma (HCC), and other liver diseases. Our group has been committed to the research of liver disease diagnosis and treatment targets. We review the function and mechanism of circRNA in ALI, HF and HCC, expecting to provide new ideas for the diagnosis, treatment, and prognosis of liver diseases.https://www.mdpi.com/2073-4409/11/12/1948circular RNA (circRNA)alcoholic liver injury (ALI)hepatic fibrosis (HF)hepatocellular carcinoma (HCC)exosome |
| spellingShingle | Hongwu Meng Ruowen Niu Cheng Huang Jun Li Circular RNA as a Novel Biomarker and Therapeutic Target for HCC Cells circular RNA (circRNA) alcoholic liver injury (ALI) hepatic fibrosis (HF) hepatocellular carcinoma (HCC) exosome |
| title | Circular RNA as a Novel Biomarker and Therapeutic Target for HCC |
| title_full | Circular RNA as a Novel Biomarker and Therapeutic Target for HCC |
| title_fullStr | Circular RNA as a Novel Biomarker and Therapeutic Target for HCC |
| title_full_unstemmed | Circular RNA as a Novel Biomarker and Therapeutic Target for HCC |
| title_short | Circular RNA as a Novel Biomarker and Therapeutic Target for HCC |
| title_sort | circular rna as a novel biomarker and therapeutic target for hcc |
| topic | circular RNA (circRNA) alcoholic liver injury (ALI) hepatic fibrosis (HF) hepatocellular carcinoma (HCC) exosome |
| url | https://www.mdpi.com/2073-4409/11/12/1948 |
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