EREG is a risk factor for the prognosis of patients with cervical cancer
BackgroundCervical cancer continues to threaten women's health worldwide. Identifying critical oncogenic molecules is important to drug development and prognosis prediction for patients with cervical cancer. Recent studies have demonstrated that epiregulin (EREG) is upregulated in various cance...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1161835/full |
| _version_ | 1797867246520893440 |
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| author | Tianye Li Ruijing Feng Bingxin Chen Jianwei Zhou |
| author_facet | Tianye Li Ruijing Feng Bingxin Chen Jianwei Zhou |
| author_sort | Tianye Li |
| collection | DOAJ |
| description | BackgroundCervical cancer continues to threaten women's health worldwide. Identifying critical oncogenic molecules is important to drug development and prognosis prediction for patients with cervical cancer. Recent studies have demonstrated that epiregulin (EREG) is upregulated in various cancer types, which contributes to cancer progression by triggering the EGFR signaling pathway. However, the role of EREG is still unclear.MethodsIn this study, we first conducted a comprehensive biological analysis to investigate the expression of EREG in cervical cancer. Then, we investigated the correlations between EREG expression level and clinicopathological features. In addition, we validated the effects of EREG expression on the proliferation and apoptosis of cervical cancer cells.ResultsBased on the public database, we found that the expression of EREG was higher in advanced cervical cancer samples. Survival analysis showed that EREG was a risk factor for the prognosis of cervical cancer. In vitro experiments demonstrated that EREG knockdown undermined proliferation and promoted apoptosis in cancer cells.ConclusionEREG plays a vital role in the progression of cervical cancer, which contributes to hyperactive cell proliferation and decreased cell apoptosis. It might be a valuable target for prognosis prediction and drug development for cervical cancer in the future. |
| first_indexed | 2024-04-09T23:37:13Z |
| format | Article |
| id | doaj.art-613e52262f8a4de19ff11ffc0430180d |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-09T23:37:13Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-613e52262f8a4de19ff11ffc0430180d2023-03-20T04:37:26ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-03-011010.3389/fmed.2023.11618351161835EREG is a risk factor for the prognosis of patients with cervical cancerTianye Li0Ruijing Feng1Bingxin Chen2Jianwei Zhou3Department of Gynecology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Obstetrics and Gynecology, The Central Hospital of Wuhan, Wuhan, ChinaDepartment of Gynecologic Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Gynecology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaBackgroundCervical cancer continues to threaten women's health worldwide. Identifying critical oncogenic molecules is important to drug development and prognosis prediction for patients with cervical cancer. Recent studies have demonstrated that epiregulin (EREG) is upregulated in various cancer types, which contributes to cancer progression by triggering the EGFR signaling pathway. However, the role of EREG is still unclear.MethodsIn this study, we first conducted a comprehensive biological analysis to investigate the expression of EREG in cervical cancer. Then, we investigated the correlations between EREG expression level and clinicopathological features. In addition, we validated the effects of EREG expression on the proliferation and apoptosis of cervical cancer cells.ResultsBased on the public database, we found that the expression of EREG was higher in advanced cervical cancer samples. Survival analysis showed that EREG was a risk factor for the prognosis of cervical cancer. In vitro experiments demonstrated that EREG knockdown undermined proliferation and promoted apoptosis in cancer cells.ConclusionEREG plays a vital role in the progression of cervical cancer, which contributes to hyperactive cell proliferation and decreased cell apoptosis. It might be a valuable target for prognosis prediction and drug development for cervical cancer in the future.https://www.frontiersin.org/articles/10.3389/fmed.2023.1161835/fullEREGprognosis predictionbiomarkerproliferationapoptosiscervical cancer |
| spellingShingle | Tianye Li Ruijing Feng Bingxin Chen Jianwei Zhou EREG is a risk factor for the prognosis of patients with cervical cancer Frontiers in Medicine EREG prognosis prediction biomarker proliferation apoptosis cervical cancer |
| title | EREG is a risk factor for the prognosis of patients with cervical cancer |
| title_full | EREG is a risk factor for the prognosis of patients with cervical cancer |
| title_fullStr | EREG is a risk factor for the prognosis of patients with cervical cancer |
| title_full_unstemmed | EREG is a risk factor for the prognosis of patients with cervical cancer |
| title_short | EREG is a risk factor for the prognosis of patients with cervical cancer |
| title_sort | ereg is a risk factor for the prognosis of patients with cervical cancer |
| topic | EREG prognosis prediction biomarker proliferation apoptosis cervical cancer |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1161835/full |
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