Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation
Heat shock factor (Hsf1) regulates the expression of molecular chaperones to maintain protein homeostasis. Despite its central role in stress resistance, disease and aging, the mechanisms that control Hsf1 activity remain unresolved. Here we show that in budding yeast, Hsf1 basally associates with t...
Main Authors: | Xu Zheng, Joanna Krakowiak, Nikit Patel, Ali Beyzavi, Jideofor Ezike, Ahmad S Khalil, David Pincus |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2016-11-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/18638 |
Similar Items
-
Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation
by: Zheng, Xu, et al.
Published: (2017) -
Cytoplasmic protein misfolding titrates Hsp70 to activate nuclear Hsf1
by: Anna E Masser, et al.
Published: (2019-09-01) -
A model for handling cell stress
by: Laura Le Breton, et al.
Published: (2016-11-01) -
Transcriptional regulation of Sis1 promotes fitness but not feedback in the heat shock response
by: Rania Garde, et al.
Published: (2023-05-01) -
HSF1: Primary Factor in Molecular Chaperone Expression and a Major Contributor to Cancer Morbidity
by: Thomas L. Prince, et al.
Published: (2020-04-01)