Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation

Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation

Heat shock factor (Hsf1) regulates the expression of molecular chaperones to maintain protein homeostasis. Despite its central role in stress resistance, disease and aging, the mechanisms that control Hsf1 activity remain unresolved. Here we show that in budding yeast, Hsf1 basally associates with t...

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Bibliographic Details
Main Authors: Xu Zheng, Joanna Krakowiak, Nikit Patel, Ali Beyzavi, Jideofor Ezike, Ahmad S Khalil, David Pincus
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-11-01
Series:eLife
Subjects:
heat shock
Hsf1
Hsp70
phosphorylation
chaperone
systems modeling
Online Access:https://elifesciences.org/articles/18638

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