Serum omentin-1, vaspin, and apelin levels and central obesity in patients with nonalcoholic fatty liver disease
Background: Omentin-1, vaspin, and apelin are novel adipokines which closely associate with obesity, nonalcoholic fatty liver disease (NAFLD), and inflammation. The aim of this study was to investigate the circulating levels of omentin-1, vaspin, and apelin in NAFLD patients and to clarify their rel...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Journal of Research in Medical Sciences |
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| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2017;volume=22;issue=1;spage=70;epage=70;aulast=Montazerifar |
| _version_ | 1818422664459452416 |
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| author | Farzaneh Montazerifar Ali Reza Bakhshipour Mansour Karajibani Zahra Torki Ali Reza Dashipour |
| author_facet | Farzaneh Montazerifar Ali Reza Bakhshipour Mansour Karajibani Zahra Torki Ali Reza Dashipour |
| author_sort | Farzaneh Montazerifar |
| collection | DOAJ |
| description | Background: Omentin-1, vaspin, and apelin are novel adipokines which closely associate with obesity, nonalcoholic fatty liver disease (NAFLD), and inflammation. The aim of this study was to investigate the circulating levels of omentin-1, vaspin, and apelin in NAFLD patients and to clarify their relationship with biochemical parameters, abdominal obesity, and high sensitive C-reactive protein. Materials and Methods: In a case–control study, serum levels of omentin-1, vaspin, and apelin were measured in 41 NAFLD patients and 41 healthy volunteers. The study was performed in the outpatients' clinic of Imam-Ali Hospital in Zahedan, Iran, during February to July 2015. Fatty liver was confirmed by ultrasonography. The association of the adipokines with lipid profile and anthropometric parameters was assessed using multivariable linear regression models. In this model, those variables that showedP< 0.05 were included in the study. Results: NAFLD patients presented a significantly higher apelin levels compared to the controls (P < 0.01), whereas serum omentin-1 and vaspin levels did not differ between two groups (both P> 0.05). Multiple regression analysis showed that the serum levels of apelin and vaspin correlated positively with waist circumference (WC) (P < 0.01 andP< 0.05, respectively) and low-density lipoprotein (P < 0.05 andP< 0.01, respectively) while serum omentin-1 was inversely correlated with WC (P < 0.01) and positively corrected with high-density lipoprotein (P < 0.05). Conclusion: The findings showed that among the analyzed adipokines only apelin was different in patients with NAFLD when compared to controls. Considering the multivariate regression analysis, apelin seems be more suitable diagnostic marker in predicting of NAFLD and omentin might be considered as a protective factor in occurrence of NAFLD, particularly in those with central obesity. |
| first_indexed | 2024-12-14T13:29:51Z |
| format | Article |
| id | doaj.art-613ea19dd3a349da9a847096316f959b |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-12-14T13:29:51Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-613ea19dd3a349da9a847096316f959b2022-12-21T22:59:44ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362017-01-01221707010.4103/jrms.JRMS_788_16Serum omentin-1, vaspin, and apelin levels and central obesity in patients with nonalcoholic fatty liver diseaseFarzaneh MontazerifarAli Reza BakhshipourMansour KarajibaniZahra TorkiAli Reza DashipourBackground: Omentin-1, vaspin, and apelin are novel adipokines which closely associate with obesity, nonalcoholic fatty liver disease (NAFLD), and inflammation. The aim of this study was to investigate the circulating levels of omentin-1, vaspin, and apelin in NAFLD patients and to clarify their relationship with biochemical parameters, abdominal obesity, and high sensitive C-reactive protein. Materials and Methods: In a case–control study, serum levels of omentin-1, vaspin, and apelin were measured in 41 NAFLD patients and 41 healthy volunteers. The study was performed in the outpatients' clinic of Imam-Ali Hospital in Zahedan, Iran, during February to July 2015. Fatty liver was confirmed by ultrasonography. The association of the adipokines with lipid profile and anthropometric parameters was assessed using multivariable linear regression models. In this model, those variables that showedP< 0.05 were included in the study. Results: NAFLD patients presented a significantly higher apelin levels compared to the controls (P < 0.01), whereas serum omentin-1 and vaspin levels did not differ between two groups (both P> 0.05). Multiple regression analysis showed that the serum levels of apelin and vaspin correlated positively with waist circumference (WC) (P < 0.01 andP< 0.05, respectively) and low-density lipoprotein (P < 0.05 andP< 0.01, respectively) while serum omentin-1 was inversely correlated with WC (P < 0.01) and positively corrected with high-density lipoprotein (P < 0.05). Conclusion: The findings showed that among the analyzed adipokines only apelin was different in patients with NAFLD when compared to controls. Considering the multivariate regression analysis, apelin seems be more suitable diagnostic marker in predicting of NAFLD and omentin might be considered as a protective factor in occurrence of NAFLD, particularly in those with central obesity.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2017;volume=22;issue=1;spage=70;epage=70;aulast=MontazerifarAdipokinesapelincentral obesitynonalcoholic fatty liver diseaseomentinvaspin |
| spellingShingle | Farzaneh Montazerifar Ali Reza Bakhshipour Mansour Karajibani Zahra Torki Ali Reza Dashipour Serum omentin-1, vaspin, and apelin levels and central obesity in patients with nonalcoholic fatty liver disease Journal of Research in Medical Sciences Adipokines apelin central obesity nonalcoholic fatty liver disease omentin vaspin |
| title | Serum omentin-1, vaspin, and apelin levels and central obesity in patients with nonalcoholic fatty liver disease |
| title_full | Serum omentin-1, vaspin, and apelin levels and central obesity in patients with nonalcoholic fatty liver disease |
| title_fullStr | Serum omentin-1, vaspin, and apelin levels and central obesity in patients with nonalcoholic fatty liver disease |
| title_full_unstemmed | Serum omentin-1, vaspin, and apelin levels and central obesity in patients with nonalcoholic fatty liver disease |
| title_short | Serum omentin-1, vaspin, and apelin levels and central obesity in patients with nonalcoholic fatty liver disease |
| title_sort | serum omentin 1 vaspin and apelin levels and central obesity in patients with nonalcoholic fatty liver disease |
| topic | Adipokines apelin central obesity nonalcoholic fatty liver disease omentin vaspin |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2017;volume=22;issue=1;spage=70;epage=70;aulast=Montazerifar |
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