New Prognostic Biomarkers in Metastatic Castration-Resistant Prostate Cancer
Prostate cancer is one of the most frequent cancers in men and is a common cause of cancer-related death. Despite significant progress in the diagnosis and treatment of this tumor, patients who relapse after radical treatments inevitably develop metastatic disease. Patient stratification is therefor...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/1/193 |
| _version_ | 1797409743346597888 |
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| author | Vincenza Conteduca Alessandra Mosca Nicole Brighi Ugo de Giorgi Pasquale Rescigno |
| author_facet | Vincenza Conteduca Alessandra Mosca Nicole Brighi Ugo de Giorgi Pasquale Rescigno |
| author_sort | Vincenza Conteduca |
| collection | DOAJ |
| description | Prostate cancer is one of the most frequent cancers in men and is a common cause of cancer-related death. Despite significant progress in the diagnosis and treatment of this tumor, patients who relapse after radical treatments inevitably develop metastatic disease. Patient stratification is therefore key in this type of cancer, and there is an urgent need for prognostic biomarkers that can define patients’ risk of cancer-related death. In the last 10 years, multiple prognostic factors have been identified and studied. Here, we review the literature available and discuss the most common aberrant genomic pathways in metastatic castration-resistant prostate cancer shown to have a prognostic relevance in this setting. |
| first_indexed | 2024-03-09T04:20:02Z |
| format | Article |
| id | doaj.art-6140144a124a4f4e8efbe5b081883273 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T04:20:02Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-6140144a124a4f4e8efbe5b0818832732023-12-03T13:48:59ZengMDPI AGCells2073-44092021-01-0110119310.3390/cells10010193New Prognostic Biomarkers in Metastatic Castration-Resistant Prostate CancerVincenza Conteduca0Alessandra Mosca1Nicole Brighi2Ugo de Giorgi3Pasquale Rescigno4Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 47014 Meldola, ItalyMultidisciplinary Outpatient Oncology Clinic, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Turin, ItalyDepartment of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 47014 Meldola, ItalyDepartment of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 47014 Meldola, ItalyInterdisciplinary Group for Translational Research and Clinical Trials, Urological Cancers (GIRT-Uro), Candiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Turin, ItalyProstate cancer is one of the most frequent cancers in men and is a common cause of cancer-related death. Despite significant progress in the diagnosis and treatment of this tumor, patients who relapse after radical treatments inevitably develop metastatic disease. Patient stratification is therefore key in this type of cancer, and there is an urgent need for prognostic biomarkers that can define patients’ risk of cancer-related death. In the last 10 years, multiple prognostic factors have been identified and studied. Here, we review the literature available and discuss the most common aberrant genomic pathways in metastatic castration-resistant prostate cancer shown to have a prognostic relevance in this setting.https://www.mdpi.com/2073-4409/10/1/193prostate cancerandrogen receptorPTENDNA repair defectsprognostic biomarkers |
| spellingShingle | Vincenza Conteduca Alessandra Mosca Nicole Brighi Ugo de Giorgi Pasquale Rescigno New Prognostic Biomarkers in Metastatic Castration-Resistant Prostate Cancer Cells prostate cancer androgen receptor PTEN DNA repair defects prognostic biomarkers |
| title | New Prognostic Biomarkers in Metastatic Castration-Resistant Prostate Cancer |
| title_full | New Prognostic Biomarkers in Metastatic Castration-Resistant Prostate Cancer |
| title_fullStr | New Prognostic Biomarkers in Metastatic Castration-Resistant Prostate Cancer |
| title_full_unstemmed | New Prognostic Biomarkers in Metastatic Castration-Resistant Prostate Cancer |
| title_short | New Prognostic Biomarkers in Metastatic Castration-Resistant Prostate Cancer |
| title_sort | new prognostic biomarkers in metastatic castration resistant prostate cancer |
| topic | prostate cancer androgen receptor PTEN DNA repair defects prognostic biomarkers |
| url | https://www.mdpi.com/2073-4409/10/1/193 |
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