Features of nervous system damage in antiphospholipid syndrome
Antiphospholipid syndrome (APS) is an autoimmune process that increases the risk of arterial and venous thrombosis. The mechanism of damage to the central nervous system (CNS) can be not only due to thrombosis, but also antiphospholipid antibodies (APA) circulating in the peripheral blood. The latte...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2021-09-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/1069 |
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| author | O. N. Voskresenskaya V. O. Bitsadze J. Kh. Khizroeva T. A. Sukontseva M. V. Tretyakova A. S. Shkoda J.-C. Gris I. Elalamy G. Rizzo D. V. Blinov A. D. Makatsariya |
| author_facet | O. N. Voskresenskaya V. O. Bitsadze J. Kh. Khizroeva T. A. Sukontseva M. V. Tretyakova A. S. Shkoda J.-C. Gris I. Elalamy G. Rizzo D. V. Blinov A. D. Makatsariya |
| author_sort | O. N. Voskresenskaya |
| collection | DOAJ |
| description | Antiphospholipid syndrome (APS) is an autoimmune process that increases the risk of arterial and venous thrombosis. The mechanism of damage to the central nervous system (CNS) can be not only due to thrombosis, but also antiphospholipid antibodies (APA) circulating in the peripheral blood. The latter can damage the cerebral vascular endothelium, alter the resistance of the blood-brain barrier and penetrate into the central nervous system, exerting a damaging effect on astroglia and neurons, as evidenced by the release of neurospecific proteins into the peripheral bloodstream. The role of APS in developing cerebral ischemia, migraine, epilepsy, chorea, transverse myelitis, multiple sclerosis, cognitive impairment and mental disorders, as well as the peripheral nervous system is described. It should also be noted about a role of APS for emerging neurological disorders in COVID-19, enabled apart from thrombogenesis due to APA via 2 potential mechanisms - molecular mimicry and neoepitope formation. Further study of the APS pathogenesis and interdisciplinary interaction are necessary to develop effective methods for patient management. |
| first_indexed | 2024-04-10T04:01:38Z |
| format | Article |
| id | doaj.art-6141042651d44025a2d839125e98c7a8 |
| institution | Directory Open Access Journal |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| last_indexed | 2024-04-10T04:01:38Z |
| publishDate | 2021-09-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj.art-6141042651d44025a2d839125e98c7a82023-03-13T07:09:51ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942021-09-0115440441410.17749/2313-7347/ob.gyn.rep.2021.242664Features of nervous system damage in antiphospholipid syndromeO. N. Voskresenskaya0V. O. Bitsadze1J. Kh. Khizroeva2T. A. Sukontseva3M. V. Tretyakova4A. S. Shkoda5J.-C. Gris6I. Elalamy7G. Rizzo8D. V. Blinov9A. D. Makatsariya10Sechenov UniversitySechenov UniversitySechenov UniversityPavlov First Saint Petersburg State Medical University, Health Ministry of Russian Federation«Medical Center» LLCVorokhobov City Clinical Hospital № 67, Moscow Healthcare DepartmentSechenov University; University of MontpellierSechenov University; Medicine Sorbonne University; Hospital TenonSechenov University; University of Rome Tor VergataInstitute for Preventive and Social Medicine; Lapino Clinic Hospital, MD Medical GroupSechenov UniversityAntiphospholipid syndrome (APS) is an autoimmune process that increases the risk of arterial and venous thrombosis. The mechanism of damage to the central nervous system (CNS) can be not only due to thrombosis, but also antiphospholipid antibodies (APA) circulating in the peripheral blood. The latter can damage the cerebral vascular endothelium, alter the resistance of the blood-brain barrier and penetrate into the central nervous system, exerting a damaging effect on astroglia and neurons, as evidenced by the release of neurospecific proteins into the peripheral bloodstream. The role of APS in developing cerebral ischemia, migraine, epilepsy, chorea, transverse myelitis, multiple sclerosis, cognitive impairment and mental disorders, as well as the peripheral nervous system is described. It should also be noted about a role of APS for emerging neurological disorders in COVID-19, enabled apart from thrombogenesis due to APA via 2 potential mechanisms - molecular mimicry and neoepitope formation. Further study of the APS pathogenesis and interdisciplinary interaction are necessary to develop effective methods for patient management.https://www.gynecology.su/jour/article/view/1069antiphospholipid syndromeapscentral nervous systemcnsperipheral nervous systemischemiamigraineepilepsychoreatransverse myelitisdisseminated sclerosiscovid-19 |
| spellingShingle | O. N. Voskresenskaya V. O. Bitsadze J. Kh. Khizroeva T. A. Sukontseva M. V. Tretyakova A. S. Shkoda J.-C. Gris I. Elalamy G. Rizzo D. V. Blinov A. D. Makatsariya Features of nervous system damage in antiphospholipid syndrome Акушерство, гинекология и репродукция antiphospholipid syndrome aps central nervous system cns peripheral nervous system ischemia migraine epilepsy chorea transverse myelitis disseminated sclerosis covid-19 |
| title | Features of nervous system damage in antiphospholipid syndrome |
| title_full | Features of nervous system damage in antiphospholipid syndrome |
| title_fullStr | Features of nervous system damage in antiphospholipid syndrome |
| title_full_unstemmed | Features of nervous system damage in antiphospholipid syndrome |
| title_short | Features of nervous system damage in antiphospholipid syndrome |
| title_sort | features of nervous system damage in antiphospholipid syndrome |
| topic | antiphospholipid syndrome aps central nervous system cns peripheral nervous system ischemia migraine epilepsy chorea transverse myelitis disseminated sclerosis covid-19 |
| url | https://www.gynecology.su/jour/article/view/1069 |
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