Cardiovascular risk factors in mild adrenal autonomous cortisol secretion in a Caucasian population
Cardiovascular risk factors could be present in mild adrenal au tonomous cortisol secretion (MACS). However, the most frequent cardiovascular risk factors in MACS have not been established. The aim of the present study was to analyse the di fference in cardiovascular risk factors in patients with MA...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2022-08-01
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| Series: | Endocrine Connections |
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| Online Access: | https://ec.bioscientifica.com/view/journals/ec/11/9/EC-22-0074.xml |
| _version_ | 1798037907821297664 |
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| author | Agnieszka Adamska Vitalii Ulychnyi Katarzyna Siewko Anna Popławska-Kita Małgorzata Szelachowska Marcin Adamski Angelika Buczyńska Adam Jacek Krętowski |
| author_facet | Agnieszka Adamska Vitalii Ulychnyi Katarzyna Siewko Anna Popławska-Kita Małgorzata Szelachowska Marcin Adamski Angelika Buczyńska Adam Jacek Krętowski |
| author_sort | Agnieszka Adamska |
| collection | DOAJ |
| description | Cardiovascular risk factors could be present in mild adrenal au tonomous cortisol secretion (MACS). However, the most frequent cardiovascular risk factors in MACS have not been established. The aim of the present study was to analyse the di fference in cardiovascular risk factors in patients with MACS in comparison to those with non-functioning adrenal tumour (NFAT). A total of 295 patients with adrenal incidentalo ma were included in this retrospective study. We divided our group into those who showed suppression in 1 mg overnight dexamethasone suppression test (DST) (NFAT) (serum co rtisol level ≤1.8 μg/ dL) and those who did not show suppression in the DST (MACS) (s erum concentration of cortisol > 1.8 μg/dL and ≤5 μg/dL). In the studied groups, we analysed the presence of cardiovascular risk factors, such as obesity, prediabetes, type 2 diabetes mellitus (T2DM), hypertension, hyperlipidaemia, chronic kidney disease and cardiovascular events. In our study, 18.9% of patients were defined as MACS. Importantly, T2DM was diagnosed in 41% of MACS vs 23% of NFAT (P < 0.01) and higher frequency of occurrence of hyperlipidaemia in NFAT (72.4%) vs MACS (53.6%) (P = 0.01) was observed. We did not observed differences in the frequency of obesity, hypertension, chronic kidney disea se, prediabetes, atrial fibrillation, stroke, ST and non-ST elevation myocardial infarct ion and coronary angioplasty between patients with MACS and NFAT (all P > 0.05; respectively). In MACS, T2DM is more prevalent than in NFAT; hyperlipidaemia is more prevalent in NFAT. Accordingly, no differences were found in the incidence of obesity, hypertension , prediabetes, chronic kidney disease between studied groups as well as cardiovascular events. |
| first_indexed | 2024-04-11T21:32:58Z |
| format | Article |
| id | doaj.art-6141cbee010a478d82ab3251e82dd74c |
| institution | Directory Open Access Journal |
| issn | 2049-3614 |
| language | English |
| last_indexed | 2024-04-11T21:32:58Z |
| publishDate | 2022-08-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-6141cbee010a478d82ab3251e82dd74c2022-12-22T04:01:51ZengBioscientificaEndocrine Connections2049-36142022-08-0111919https://doi.org/10.1530/EC-22-0074Cardiovascular risk factors in mild adrenal autonomous cortisol secretion in a Caucasian populationAgnieszka Adamska0Vitalii Ulychnyi1Katarzyna Siewko2Anna Popławska-Kita3Małgorzata Szelachowska4Marcin Adamski5Angelika Buczyńska6Adam Jacek Krętowski7Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Bialystok, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Bialystok, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Bialystok, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Bialystok, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Bialystok, PolandFaculty of Computer Science, Bialystok University of Technology, Białystok, PolandClinical Research Centre, Medical University of Bialystok, Bialystok, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Bialystok, Poland; Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland Cardiovascular risk factors could be present in mild adrenal au tonomous cortisol secretion (MACS). However, the most frequent cardiovascular risk factors in MACS have not been established. The aim of the present study was to analyse the di fference in cardiovascular risk factors in patients with MACS in comparison to those with non-functioning adrenal tumour (NFAT). A total of 295 patients with adrenal incidentalo ma were included in this retrospective study. We divided our group into those who showed suppression in 1 mg overnight dexamethasone suppression test (DST) (NFAT) (serum co rtisol level ≤1.8 μg/ dL) and those who did not show suppression in the DST (MACS) (s erum concentration of cortisol > 1.8 μg/dL and ≤5 μg/dL). In the studied groups, we analysed the presence of cardiovascular risk factors, such as obesity, prediabetes, type 2 diabetes mellitus (T2DM), hypertension, hyperlipidaemia, chronic kidney disease and cardiovascular events. In our study, 18.9% of patients were defined as MACS. Importantly, T2DM was diagnosed in 41% of MACS vs 23% of NFAT (P < 0.01) and higher frequency of occurrence of hyperlipidaemia in NFAT (72.4%) vs MACS (53.6%) (P = 0.01) was observed. We did not observed differences in the frequency of obesity, hypertension, chronic kidney disea se, prediabetes, atrial fibrillation, stroke, ST and non-ST elevation myocardial infarct ion and coronary angioplasty between patients with MACS and NFAT (all P > 0.05; respectively). In MACS, T2DM is more prevalent than in NFAT; hyperlipidaemia is more prevalent in NFAT. Accordingly, no differences were found in the incidence of obesity, hypertension , prediabetes, chronic kidney disease between studied groups as well as cardiovascular events.https://ec.bioscientifica.com/view/journals/ec/11/9/EC-22-0074.xmltype 2 diabeteshyperlipidaemiaadrenal incidentaloma |
| spellingShingle | Agnieszka Adamska Vitalii Ulychnyi Katarzyna Siewko Anna Popławska-Kita Małgorzata Szelachowska Marcin Adamski Angelika Buczyńska Adam Jacek Krętowski Cardiovascular risk factors in mild adrenal autonomous cortisol secretion in a Caucasian population Endocrine Connections type 2 diabetes hyperlipidaemia adrenal incidentaloma |
| title | Cardiovascular risk factors in mild adrenal autonomous cortisol secretion in a Caucasian population |
| title_full | Cardiovascular risk factors in mild adrenal autonomous cortisol secretion in a Caucasian population |
| title_fullStr | Cardiovascular risk factors in mild adrenal autonomous cortisol secretion in a Caucasian population |
| title_full_unstemmed | Cardiovascular risk factors in mild adrenal autonomous cortisol secretion in a Caucasian population |
| title_short | Cardiovascular risk factors in mild adrenal autonomous cortisol secretion in a Caucasian population |
| title_sort | cardiovascular risk factors in mild adrenal autonomous cortisol secretion in a caucasian population |
| topic | type 2 diabetes hyperlipidaemia adrenal incidentaloma |
| url | https://ec.bioscientifica.com/view/journals/ec/11/9/EC-22-0074.xml |
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