| Summary: | This study investigates the impact of various zinc supplementation methods on anemia in rats induced by phenylhydrazine (PHZ) and in 5/6-nephrectomized anemic rats. We compare oral zinc sulfate (ZnSO<sub>4</sub>) supplementation, oyster <i>Crassostrea gigas</i> supplementation, and hard clam <i>Meretrix lusoria</i> supplementation on red blood cell (RBC) levels. Oral zinc-rich oyster supplementation (2.70 mg Zn (30 g oyster)/day/rat) effectively corrects anemia in both experimental groups. Rats orally fed oysters for four days exhibit similar effectiveness as those receiving a single ZnSO<sub>4</sub> injection (0.95 mg Zn (4.18 mg ZnSO<sub>4</sub>⋅7H<sub>2</sub>O)/rat). In contrast, oral ZnSO<sub>4</sub> supplementation (2.70 mg Zn (11.88 mg ZnSO<sub>4</sub>⋅7H<sub>2</sub>O)/day/rat) does not significantly increase RBC levels, suggesting better zinc absorption from oysters. A placebo group of anemic rats supplemented with hard clams, similar in composition to oysters but much lower in zinc, did not change RBC counts. This supports oysters’ high zinc content as the key to correcting anemia. Oysters also contain high iron levels, offering a potential solution for iron-deficiency anemia while supporting bone marrow erythropoiesis. In summary, oral oyster supplementation emerges as an effective strategy to correct anemia in rats with added zinc and iron support for erythropoiesis.
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