Class II HDAC inhibition hampers hepatic stellate cell activation by induction of microRNA-29.

Class II HDAC inhibition hampers hepatic stellate cell activation by induction of microRNA-29.

<h4>Background</h4>The conversion of a quiescent vitamin A storing hepatic stellate cell (HSC) to a matrix producing, contractile myofibroblast-like activated HSC is a key event in the onset of liver disease following injury of any aetiology. Previous studies have shown that class I hist...

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Bibliographic Details
Main Authors: Inge Mannaerts, Nathalie Eysackers, Oscar O Onyema, Katrien Van Beneden, Sergio Valente, Antonello Mai, Margarete Odenthal, Leo A van Grunsven
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23383282/?tool=EBI

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